益生菌影响认知功能的研究进展
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- 英文论文题名：Research advances in probiotics and cognitivefunction
- 论文作者：蒲芳芳 ; 于晓红 ; 李姗珊 ; 伍梓汐 ; 李鸣 ; 何方
- 英文论文作者：Pu Fangfang ; Yu Xiaohong ; Li Shanshan ; Wu Zixi ; Li Ming ; He Fang ; West China School of Public Health ; Sichuan University
- 年：2016
- 作者机构：四川大学华西公共卫生学院;
- 论文关键词：益生菌 ; 肠道菌群 ; 认知功能 ; 衰退
- 英文论文关键词：probiotics ; intestinal flora ; cognitive function ; decline
- 会议召开时间：2016-11-09
- 会议录名称：中国食品科学技术学会第十三届年会论文摘要集
- 英文会议录名称：Abstracts of the 13th Annual Meeting of CIFST
- 语种：中文
- 分类号：TS201.4
- 学会代码：ZGSP
- 会议名称：中国食品科学技术学会第十三届年会
- 会议地点：中国北京
- 主办单位：中国食品科学技术学会
- 学会名称：中国食品科学技术学会
- 页数：2
- 文件大小：109k
- 原文格式：O
- 会议级别：全国
摘要
随着年龄增长,人的认知功能可能出现量和质的衰退,轻则影响生活质量,重则导致痴呆,目前尚无特效治疗方法逆转认知功能衰退甚至痴呆的发生。随着微生态学的发展,大量科学证据表明肠道菌群可通过神经、内分泌、代谢及免疫等多种途径影响认知功能,益生菌可能会成为预防或改善认知功能衰退的有效手段之一。本研究就目前益生菌与认知功能的研究进行了综述,发现益生菌改善认知功能的可能机制除了调节肠道菌群以外,还可能有①降低全身炎症因子的活性,缓解脑部的慢性炎症;②促进外源性多胺(包括腐胺、精脒和精胺)的产生。多胺可以增加肠腔黏液的分泌,预防肠道屏障功能破坏,抑制炎症因子的产生,其抗诱变剂和抗氧化的特性还可以延缓衰老;③促进血清素前体色氨酸和脑衍生神经营养因子的提高,有助于抑郁症及认知功能障碍疾病的预防和早期治疗等。同时本研究还发现益生菌对认知功能的效果还存在争议,动物实验结果外推至人群有一定难度,这可能与益生菌的菌种/株特异性有关。有关益生菌可能改善宿主认知功能衰退的健康促进作用,还需大规模临床试验来进行验证,以及在菌株水平进行可能的机制分析。
Ageing may decline the human cognitive functionquantity and quality.These changes would affect the quahty of life,or even lead to dementia.Unfortunaltly,there is no treatment effective enough to reverse cognitive decline or even dementia occurs.Accumulating scientific evidencesinintestinal microbiology suggest that the intestinal microbes can affect cognitive function by cross talking with humanneural,endocrine,metabolicand immune systems.Probiotic supplements could beused as one of potent means to prevent or improve cognitive decline.Thepresent study reviewed /analyzed thecurrent studiesrelated to probiotics and cognitive function.As results,the possible mechanisms by whichprobiotics might improve cognitive function have been found to include(a) reducing the activity of systemic inflammation factors and relieving the chronic inflammation of the brain;(b) promoting the production of exogenous polyamines(including putrescine,spermidine and spermine),which can increase the secretion of intestinal mucus,prevent the destruction of the intestine barrier,inhibit the production of inflammatory cytokines,and retard aging attributed to the feature of anti-mutagenic and anti-oxidation;(c) promoting the secretion of tryptophan(serotonin precursor) and brain-derived neurotrophic factor,contributing to the prevention and early treatment of depression and cognitive disorders as well as well know ability of probiotic to regulate intestinal microbiota.The present study has also found that the effect of probiotics on cognitive function was still controversial among different experimental models and greatly changed in individual dependent manner.The results of animal experiments could not be extrapolated to human model right now.All of these may be associated with the species/strain-specific of probiotics.Therefore,further studies should be conducted to evaluate the health benefits of probiotics to improve the host cognitive in large-scale clinical trials and the related underlying mechanism should be characterized with each signal strain.
Ageing may decline the human cognitive functionquantity and quality.These changes would affect the quahty of life,or even lead to dementia.Unfortunaltly,there is no treatment effective enough to reverse cognitive decline or even dementia occurs.Accumulating scientific evidencesinintestinal microbiology suggest that the intestinal microbes can affect cognitive function by cross talking with humanneural,endocrine,metabolicand immune systems.Probiotic supplements could beused as one of potent means to prevent or improve cognitive decline.Thepresent study reviewed /analyzed thecurrent studiesrelated to probiotics and cognitive function.As results,the possible mechanisms by whichprobiotics might improve cognitive function have been found to include(a) reducing the activity of systemic inflammation factors and relieving the chronic inflammation of the brain;(b) promoting the production of exogenous polyamines(including putrescine,spermidine and spermine),which can increase the secretion of intestinal mucus,prevent the destruction of the intestine barrier,inhibit the production of inflammatory cytokines,and retard aging attributed to the feature of anti-mutagenic and anti-oxidation;(c) promoting the secretion of tryptophan(serotonin precursor) and brain-derived neurotrophic factor,contributing to the prevention and early treatment of depression and cognitive disorders as well as well know ability of probiotic to regulate intestinal microbiota.The present study has also found that the effect of probiotics on cognitive function was still controversial among different experimental models and greatly changed in individual dependent manner.The results of animal experiments could not be extrapolated to human model right now.All of these may be associated with the species/strain-specific of probiotics.Therefore,further studies should be conducted to evaluate the health benefits of probiotics to improve the host cognitive in large-scale clinical trials and the related underlying mechanism should be characterized with each signal strain.
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