不同剂量度洛西汀治疗广泛性焦虑障碍的疗效与安全性观察
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- 英文论文题名：An Observation on the Effect and Safety of Different Doses of Duloxetine in Treating Generalized Anxiety Disorder
- 论文作者：耿松 ; 朱毅平 ; 郭萍 ; 金学敏 ; 杨胜良
- 英文论文作者：Geng Song ; Zhu YiPing ; Guo Ping ; Jin XueMin ; Yang ShengLiang ; No.3 Hospital Psychology ; Huzhou
- 年：2014
- 作者机构：湖州市第三人民医院心身障碍科;
- 论文关键词：广泛性焦虑障碍 ; 度洛西汀 ; 帕罗西汀 ; 疗效 ; 安全性
- 英文论文关键词：Generalized Anxiety Disorder ; Duloxetine ; Paroxitinte ; Curative Effect ; Safe
- 会议召开时间：2014-11-20
- 会议录名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会论文汇编
- 语种：中文
- 分类号：R749.72
- 学会代码：ZJKX
- 会议名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会
- 会议地点：中国浙江湖州
- 主办单位：浙江省医学会精神病学分会（The Society of Psychiatry ; ZJMA）、浙江省医师协会精神科医师分会
- 学会名称：浙江省科学技术协会
- 页数：4
- 文件大小：320k
- 原文格式：O
- 会议级别：地方
摘要
目的探讨不同剂量度洛西汀治疗广泛性焦虑障碍(GAD)的疗效与安全性。方法选择符合ICD-10诊断标准的GAD住院或门诊患者,随机分为四组,即度洛西汀60mg/d(A组)、度洛西汀90mg/d(B组)、度洛西汀120mg/d(C组)和帕罗西汀组(D组),帕罗西汀为可变剂量,每组各40例。入组时评定基线GAD-7、HAMA,治疗后第1、2、4、8周末,复评(评定)HAMA、TESS。入组时及第8周末查心电图、血,尿常规、肝、肾功能。A、B、C三组均在次日给予度洛西汀30mg/d,并逐渐增加到60mg/d、90mg/d、120mg/d。D组次日给予帕罗西汀10mg/d,渐增加到个体所需加量,帕罗西汀平均剂量(32.17±8.35)mg/d。度洛西汀、帕罗西汀均为早餐后服。失眠患者睡前服唑吡坦,剂量控制在10mg/d以内。结果在患者性别比、年龄、病期分布,服用唑吡坦例数、时间、剂量,基线GAD-7、HAMA得分等大致相同的情况下(P>0.05)。治疗后第2周末方差分析、两两比较,B、C组HAMA降分快于A、D组,并一直持续到第8周末。提示,度洛西汀在一定剂量范围内对GAD症状的改善呈显线性相关,即120mg/d快于90mg/d,90mg/d快于60mg/d(p<0.05、p<0.01);度洛西汀90mg/d~120mg/d对GAD症状的改善快于帕罗西汀(p<0.05、p<0.01)。60mg/d度洛西汀与帕罗西汀(32.17±8.35)mg/d,对GAD显效时间大致相同(P>0.05)。四组患者最终临床治愈率大致相当(P>0.05)。四组不良反应出现率无统计学意义(P>0.05),且较轻微。结论:1.度洛西汀在一定剂量范围内治疗GAD呈现出线性的量效相关。2.度洛西汀治疗GAD疗效确切且安全。3.度洛西汀90mg/d~120mg/d可能是治疗GAD的理想的剂量。
Objective:To research the effect and safety of different doses of Duloxetine in treating patients with generalized anxiety disorder(GAD).Method:Those hospitalized and outpatients with generalized anxiety disorder,who met the requirements of ICD-10,were selected in the survey.They were randomly divided into group A treated with Duloxetine 60mg/d,group B treated with Duloxetine 90mg/d,group C treated with Duloxetine 120mg/d and group D treated with Paroxitinte of variable doses.Each group had 40 patients.Before the research,the evaluations were taken GAD-7 and HAMA.At the end of the 1~(st),2~(nd),4~(th) and 8~(th) week,the evaluations were taken again with HAMA and TESS.Electrocardiogram,blood routine,urine routine,liver function and kidney routine were checked both before the research and at the end of the 8 week.The patients in group A,B and C were given Duloxetine 30 mg/d after the check and their doses increased to 60 mg/d,90 mg/d and 120 mg/d gradually while group D were given Paroxitinte 10 mg per day and gradually met the needs of individuals.The average dose of Paroxitinte was 32.17 ± 8.35 mg/d.Both Duloxetine and Paroxitinte were taken after breakfast.Patients with sleep disturbances were allowed to take Zolpidem less than 10mg/d before sleeping.Results:The two group's sexuality ratio、 age、 course of disease had no statistic meaning(p > 0.05).For the patients taking Zolpidem,the quantity,the time and the dose had no statistic meaning(p > 0.05).Baseline GAD-7 and HAMA scores had no statistic meaning(p > 0.05).By comparison,we can know that the HAMA scores in group B and C are lower than those in group A and D at the end of 2~(nd) week,lasting till the end of8~(th) week.As is shown,Duloxetine within certain doses has something to do with the improvement of GAD.That is,120mg/d works more than 90mg/d;90mg/d than 60mg/d(P < 0.05,P < 0.01).Duloxetine 90mg/d-120mg/d is more effective than Paroxitinte(P < 0.05,P< 0.01).Duloxetine 60mg/d has the same effect on GAD as Paroxitinte 32.17 ± 8.35 mg/d(p > 0.05).The final clinical cure rates in the four groups are almost equal(p > 0.05).The four groups have the common adverse reaction,which had no statistic meaning(P > 0.05)and slight.Conclusion:Duloxetine in treating patients with GAD within certain doses shows a dose-response relationship between linear.The effect of Duloxetine in treating patients with GAD is sure and safe.Duloxetine 90mg/d-120mg/d is likely to be the ideal dose to treat patients with GAD.
Objective:To research the effect and safety of different doses of Duloxetine in treating patients with generalized anxiety disorder(GAD).Method:Those hospitalized and outpatients with generalized anxiety disorder,who met the requirements of ICD-10,were selected in the survey.They were randomly divided into group A treated with Duloxetine 60mg/d,group B treated with Duloxetine 90mg/d,group C treated with Duloxetine 120mg/d and group D treated with Paroxitinte of variable doses.Each group had 40 patients.Before the research,the evaluations were taken GAD-7 and HAMA.At the end of the 1~(st),2~(nd),4~(th) and 8~(th) week,the evaluations were taken again with HAMA and TESS.Electrocardiogram,blood routine,urine routine,liver function and kidney routine were checked both before the research and at the end of the 8 week.The patients in group A,B and C were given Duloxetine 30 mg/d after the check and their doses increased to 60 mg/d,90 mg/d and 120 mg/d gradually while group D were given Paroxitinte 10 mg per day and gradually met the needs of individuals.The average dose of Paroxitinte was 32.17 ± 8.35 mg/d.Both Duloxetine and Paroxitinte were taken after breakfast.Patients with sleep disturbances were allowed to take Zolpidem less than 10mg/d before sleeping.Results:The two group's sexuality ratio、 age、 course of disease had no statistic meaning(p > 0.05).For the patients taking Zolpidem,the quantity,the time and the dose had no statistic meaning(p > 0.05).Baseline GAD-7 and HAMA scores had no statistic meaning(p > 0.05).By comparison,we can know that the HAMA scores in group B and C are lower than those in group A and D at the end of 2~(nd) week,lasting till the end of8~(th) week.As is shown,Duloxetine within certain doses has something to do with the improvement of GAD.That is,120mg/d works more than 90mg/d;90mg/d than 60mg/d(P < 0.05,P < 0.01).Duloxetine 90mg/d-120mg/d is more effective than Paroxitinte(P < 0.05,P< 0.01).Duloxetine 60mg/d has the same effect on GAD as Paroxitinte 32.17 ± 8.35 mg/d(p > 0.05).The final clinical cure rates in the four groups are almost equal(p > 0.05).The four groups have the common adverse reaction,which had no statistic meaning(P > 0.05)and slight.Conclusion:Duloxetine in treating patients with GAD within certain doses shows a dose-response relationship between linear.The effect of Duloxetine in treating patients with GAD is sure and safe.Duloxetine 90mg/d-120mg/d is likely to be the ideal dose to treat patients with GAD.
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