载药纳米纤维膜的制备及应用于口腔鳞癌的体外实验研究
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- 英文论文题名：Rreparation of Cisplatin/Chloroquine-Containing Nanofibrous Mats and It's In Vitro Antitumor Activity Against Oral Squamous Cell Carcinoma
- 论文作者：李霖 ; 郝岱峰 ; 郝秀峰 ; 张泽兵
- 英文论文作者：Li Lin ; Hao Daifeng ; Hao Xiufeng ; Zhang Zebing ; College of Chemistry ; Jilin University ; Departpent of Wound Repair Center ; Burn and Plastic Surgery ; First Affiliated Hospital of Chinese PLA General Hospital ; School of Stomatology ; Jilin University
- 年：2016
- 作者机构：吉林大学化学学院;中国人民解放军总医院第一附属医院;吉林大学口腔医院;
- 论文关键词：口腔鳞癌 ; 顺铂 ; 氯喹 ; 静电纺丝
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：255k
- 原文格式：D
- 会议级别：全国
摘要
口腔鳞癌是头颈部较为常见的肿瘤之一,~(1,2)近年来口腔鳞癌发病呈年轻化态势增长。由于传统的治疗药物存在明显的毒副效应,从而限制其在临床中的根本应用。因此,找寻一些新的治疗策略去弥补现在治疗方法的不足,是当前口腔医学研究领域的热点。本文利用静电纺丝技术,成功制备出载药纳米纤维膜,并对口腔癌细胞进行体外作用,系统研究了该载药缓释体系的抗癌效果。研究表明,载入顺铂药物并引入氯喹作为自噬抑制剂的聚乳酸静电纺丝膜,与正常使用药物作用CAL-27细胞相比,缓释体系具有更强、更持久的杀伤作用,同时具备良好的生物相容性。
Poly(L-lactide)(PLA) nanofibers containing the antitumor drug cisplatin/chloroquine were prepared using a one-step method by means of electrospinning of PLA solutions. The pristine and cisplatin/chloroquine-containing nanofiber mats were characterized by scanning electron microscope(SEM). SEM observation revealed that the diameter of the cisplatin/chloroquine-containing nanofiber fibers ranged from 450 nm to 650 nm. Furthermore, compared with raw cisplatin, the prepared drug-containing nanofibers showed an initial low antitumor activity and then provided a sustained antitumor efficiency. Therefore, the performance of these nanofibers makes them promising candidates for tumor treatment.
Poly(L-lactide)(PLA) nanofibers containing the antitumor drug cisplatin/chloroquine were prepared using a one-step method by means of electrospinning of PLA solutions. The pristine and cisplatin/chloroquine-containing nanofiber mats were characterized by scanning electron microscope(SEM). SEM observation revealed that the diameter of the cisplatin/chloroquine-containing nanofiber fibers ranged from 450 nm to 650 nm. Furthermore, compared with raw cisplatin, the prepared drug-containing nanofibers showed an initial low antitumor activity and then provided a sustained antitumor efficiency. Therefore, the performance of these nanofibers makes them promising candidates for tumor treatment.
引文
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