量子点-二硫化钼复合纳米片用于癌细胞的靶向荧光成像和光热治疗
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- 英文论文题名：QD-MoS_2 Nanosheets for Simultaneous Targeted Fluorescence Imaging and Photothermal Therapy
- 论文作者：张玉倩 ; 张琦 ; 翁丽星 ; 宇文力辉 ; 汪联辉
- 英文论文作者：Yuqian Zhang ; Q Zhang ; LX Weng ; LH Yuwen ; LH Wang ; Key Laboratory for Organic Electronics and Information Displays (KLOEID) and Institute of Advanced Materials (IAM) ; College of Geography and Biological Information ; Nanjing University of Posts and Telecommunications
- 年：2016
- 作者机构：有机电子与信息显示国家重点实验室培育基地先进材料研究院;地理与生物信息学院南京邮电大学;
- 论文关键词：量子点 ; 二硫化钼纳米片 ; 荧光成像 ; 光热治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;O657.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：118k
- 原文格式：D
- 会议级别：全国
摘要
近年来纳米技术飞速发展,为癌症等重大疾病的诊断与治疗提供了前所未有的机遇,尤其是新型诊疗一体化多功能纳米材料备受关注。我们制备了兼具荧光成像和光热治疗功能的量子点-二硫化钼(QD-MoS_2)纳米片。首先,通过聚乙二醇(PEG)和牛血清蛋白(BSA)对MoS_2纳米片进行表面修饰,不仅提供QD的连接位点,增强MoS_2纳米片的胶体稳定性,而且可以保持QD优异的荧光性能和MoS_2突出的光热转化能力。RGD功能化的QD-MoS_2纳米片(RGD-QD-MoS_2)不仅实现了靶向人类子宫颈癌细胞(He La)的荧光成像,而且在低强度(0.4 W/cm~2)、短时间(5 min)的近红外激光(785 nm)的照射下实现对He La细胞的高效杀伤(>85%),而正常细胞,如人类口腔上皮细胞(HOK),在相同处理条件下的存活率几乎保持100%,表明QD-MoS_2纳米片是一种兼具优异的荧光成像和光热治疗功能的新型二维纳米结构。
To realize diagnosis imaging and photothermal therapy(PTT) simultaneously, Quantum-Dots-MoS_2(QD-MoS_2) nanosheets(NSs) were fabricated. MoS_2 NSs were firstly decorated with bovine serum albumin(BSA) and thiol-PEG, which not only acted as linker for QD conjugation, but also reduced the fluorescence quenching of QDs and improved colloidal stability. The QD-MoS_2 NSs preserve excellent fluorescence property, outstanding photothermal conversion effect, and great biocompability. RGD functionalized QD-MoS_2 NSs(RGD-QD-MoS_2) were capable of not only fluorescently imaging human cervical carcinoma(He La) cells specifically, but also causing cancer cell destruction effectively. More than 85% of He La cells were killed under 785 nm laser irradiation at 0.4 W/cm~2 for 5 min, while human oral keratinocyte(HOK) cells remained nearly 100% viable. In one word, the QD-MoS_2 NSs have great potential as a theranostic agent for simultaneous fluorescence imaging and PTT.
To realize diagnosis imaging and photothermal therapy(PTT) simultaneously, Quantum-Dots-MoS_2(QD-MoS_2) nanosheets(NSs) were fabricated. MoS_2 NSs were firstly decorated with bovine serum albumin(BSA) and thiol-PEG, which not only acted as linker for QD conjugation, but also reduced the fluorescence quenching of QDs and improved colloidal stability. The QD-MoS_2 NSs preserve excellent fluorescence property, outstanding photothermal conversion effect, and great biocompability. RGD functionalized QD-MoS_2 NSs(RGD-QD-MoS_2) were capable of not only fluorescently imaging human cervical carcinoma(He La) cells specifically, but also causing cancer cell destruction effectively. More than 85% of He La cells were killed under 785 nm laser irradiation at 0.4 W/cm~2 for 5 min, while human oral keratinocyte(HOK) cells remained nearly 100% viable. In one word, the QD-MoS_2 NSs have great potential as a theranostic agent for simultaneous fluorescence imaging and PTT.
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