新型防腐剂替代品的研究及O/W纳米乳液的粒径和油相比例对防腐效果的影响的实验探讨
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- 英文论文题名：A new alterative preservation mixture and the impact of O/W nanoemulsion particle size and oil phase ratio on preservation efficacy
- 论文作者：喻敏 ; 方碧娟 ; 张婉萍
- 英文论文作者：Min Yu ; Bijjuan fang ; Wanping Zhang ; Shanghai Syntec Additive Limited ; Shanghai Institute of Applied Technology
- 年：2016
- 作者机构：上海帝科精细化工有限公司;上海应用技术大学;
- 论文关键词：防腐剂 ; 苯乙醇 ; 辛二醇 ; 单辛酸甘油酯 ; 纳米乳液 ; 粒径 ; 油相比例
- 英文论文关键词：Preservative ; Phenethyl alcohol ; Caprylyl glycol ; glyceryl caprylate ; Nanoemulsion ; Particle size ; oil phase
- 会议召开时间：2016-06-15
- 会议录名称：第十一届中国化妆品学术研讨会论文集
- 英文会议录名称：The Proceedings of the 11th Seminar on Cosmetic China
- 语种：中文
- 分类号：TQ658
- 学会代码：ZGXE
- 会议名称：第十一届中国化妆品学术研讨会
- 会议地点：中国上海
- 主办单位：中国香料香精化妆品工业协会
- 学会名称：中国香料香精化妆品工业协会
- 页数：13
- 文件大小：658k
- 原文格式：O
- 会议级别：全国
摘要
采用最低抑菌浓度(MIC)、最低杀菌浓度(MBC/MFC)和部分抑菌浓度(FIC)等实验方法研制了基于苯乙醇,辛二醇和单辛酸甘油酯复配的新型防腐剂替代品。通过防腐挑战实验(CTFA法)测试复配型防腐剂在膏霜体系中的应用,当复配型防腐剂为1.2%时,防腐效果可以满足美国个人护理用品协会(PCPC)和欧洲药典(EP)的要求。研究了O/W纳米乳液粒径和油相油脂含量对防腐效率的影响,首次报道了防腐效率与O/W乳化粒子粒径成正相关,而和乳化粒子内相油相比例成负相关的结论,并可用防腐效率公式η=D/C表达,C为油相比例,D为乳液粒径。
A new alterative preservative mixture of caprylyl glycol,glyceryl caprylate and phenethyl alcohol was prepared.The antimicrobial activity of the ingredients and the mixture preservative were determined via MIC,MBC,MFC,and fractional inhibitory concentration(FIC).The challenge test also showed that the action of the blend against microorganism completely inhibited at 1.2%,meeting the requirements of the PCPC and European Pharmacopoeia.It shows positive correlation between the antimicrobial activity of the preservative and the particle size of the emulsion droplets or the concentration of preservative in the oil phase,when the particle size of the emulsion droplets in the range of 100-900 nm.
A new alterative preservative mixture of caprylyl glycol,glyceryl caprylate and phenethyl alcohol was prepared.The antimicrobial activity of the ingredients and the mixture preservative were determined via MIC,MBC,MFC,and fractional inhibitory concentration(FIC).The challenge test also showed that the action of the blend against microorganism completely inhibited at 1.2%,meeting the requirements of the PCPC and European Pharmacopoeia.It shows positive correlation between the antimicrobial activity of the preservative and the particle size of the emulsion droplets or the concentration of preservative in the oil phase,when the particle size of the emulsion droplets in the range of 100-900 nm.
引文
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[2]Paola Ziosi,Stefano Manfredini,Alberta Vandini.Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics.Cosmetics&Toiletries,2013,128:538.
[3]Leistner.L.Basic aspects of food preservation by hurdle technology.International Journal of Food Microbiology,2005,5:181-186.
[4]SOFW Journal Group.Natural Phenethyl Alcohol-A Masking Agent with Antimicrobial Properties.SOFW Journal,2010,136.
[5]S.Fraud,EK Rees,E Mahenthiralingam,AD Russel.Aromatic alcohols and their effect on Gram-negative bacteria,cocci and mycobacteria.Journal of Antimicrobial Chemotherapy,2003,51:1435-1436.
[6]Tieman DM,Loucas HM,Kim JY.Tomato phenylacetaldehyde reductases catalyze the last step in the synthesis of the aroma volatile2-phenylethanol.Phytochemistry,2007,68:2660-2669.
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[8]F Ibarra,J Janichem,W Petersen.Efficacies of different 1,2-alkandiols as antimicrobial agents,SOFW.2008,134(4):40-48.
[9]G Bergsson.In vitro inactivation of Chlamidia trachomatis by fatty acids and monoglycerides,in Antimicrobial Agents and Chemotherapy.American Society for Microbiology.1998,42(9):2290-2294.
[10]M Kaβ,S.L(u|¨)thje,S.Herweg,S.Stepan.Systematic investigations in the antimicrobial efficacy of glycerine esters with fatty acids of different chain length.SOFW Journal.2013,12:2-6.
[11]M Kaβ,S L(u|¨)thje,S Herweg,S Stepan.Systematic investigations in the antimicrobial efficacy of glycerine esters with fatty acids of different chain length.SOFW Journal.2013,12:2-6.
[12]H Berthele,O Sella,M Lavarde.Determination of the influence of factors(ethanol,pH and a_w)on the preservation of cosmetics using experimental design.International Journal of Cosmetic Science.2014,36,54.
[13]Fratter A,Semenzato A.New association of surfactants for the production of food and cosmetic nanoemulsions:preliminary development and characterization[J].International journal of cosmetic science,2011,33(5):443-449.
[14]Silva H D,Cerqueira MA,Vicente A A.Nanoemulsions for food applications:development and characterization[J].Food and Bioprocess Technology,2012,5(3):854-867.
[15]Lee S J,Choi S J,Li Y.Protein-stabilized nanoemulsions and emulsions:comparison of physicochemical stability,lipid oxidation,and lipase digestibility[J].Journal of agricultural and food chemistry,2010,59(1):415-427.
[16]DonsiF,Sessa M,Mediouni H.Encapsulation of bioactive compounds in nanoemulsion-based delivery systems[J].Procedia Food Science,2011,1:1666-1671.
[17]Brian Sheng Xian Teo,Mahiran Basri.A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals[J].Journal of Nanobiotechnology,2010,8:4.
[18]V.Pereira,C.Diasb,M.C.Vasconcelosa.Antibacterial activity and synergistic effects between Eucalyptus globulus leaf residues(essential oils and extracts)and antibiotics against several isolates of respiratory tractinfections(Pseudomonas aeruginosa).Industrial Crops and Products,2014,52:1-7.
[19]Abderrahmane Djouahria,Boualem Sakaa.In vitro synergistic/antagonistic antibacterial and anti-inflammatory effect of various extracts/essential oil from cones of Tetraclinisarticulata(Vahl)Masters with antibiotic and anti-inflammatory agents.Industrial Crops and Products,2014,56:60-66.
[20]JoseR.Soberon,Melina A.Sgariglia,Maria R.Dip Maderuelo.Antibacterial activities of Ligaria cuneifolia and Jodina rhombifolia leaf extracts against phytopathogenic and clinical bacteria.Journal of Bioscience and Bioengineering,2014,4:1-7.
[21]Takashi Tamura,Miwa Asahara,Mikachi Yamamoto.In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes.Microbiology and Immunology,2014,58(1).
[22]Slim Smaoui,Hajer Ben Hlima.Effects of parabens and isothiazolinone on the microbiological quality of baby shampoo:the challenge test.Biocontrol science,2012,17:135-142.
[23]S.Papageorgiou,A.Varvaresou.New alternatives to cosmetics preservation.Journal of Cosmetic Science,2010,61:107-123.
[24]Paola Ziosi,Stefano Manfredini,Alberta Vandini.Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics.Cosmetics&Toiletries,2013,128:538.
[25]Stephen Clark,Paul D.I.Fletcher,Xilin Ye.Interdroplet exchange rates of water-in-oil and oil-in-water microemulsion droplets stabilized by C_(12)E_5,Langmuir,1990,6(7):1301-1309.
[26]Paul D.I.Fletcher,Andrew M.Howe,Brian H.Robinson.The linetics of solubilisate exchange between water droplets of a water-in-oil microemulsion.J.Chem.Soc,1987,83,985-1006.
[2]Paola Ziosi,Stefano Manfredini,Alberta Vandini.Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics.Cosmetics&Toiletries,2013,128:538.
[3]Leistner.L.Basic aspects of food preservation by hurdle technology.International Journal of Food Microbiology,2005,5:181-186.
[4]SOFW Journal Group.Natural Phenethyl Alcohol-A Masking Agent with Antimicrobial Properties.SOFW Journal,2010,136.
[5]S.Fraud,EK Rees,E Mahenthiralingam,AD Russel.Aromatic alcohols and their effect on Gram-negative bacteria,cocci and mycobacteria.Journal of Antimicrobial Chemotherapy,2003,51:1435-1436.
[6]Tieman DM,Loucas HM,Kim JY.Tomato phenylacetaldehyde reductases catalyze the last step in the synthesis of the aroma volatile2-phenylethanol.Phytochemistry,2007,68:2660-2669.
[7]S.Silver,L.Wendt,Mechanism of action of phenethyl alcohol:Breakdown of the cellular permeability barrier.J Bacteriology,1967,93:560-566.
[8]F Ibarra,J Janichem,W Petersen.Efficacies of different 1,2-alkandiols as antimicrobial agents,SOFW.2008,134(4):40-48.
[9]G Bergsson.In vitro inactivation of Chlamidia trachomatis by fatty acids and monoglycerides,in Antimicrobial Agents and Chemotherapy.American Society for Microbiology.1998,42(9):2290-2294.
[10]M Kaβ,S.L(u|¨)thje,S.Herweg,S.Stepan.Systematic investigations in the antimicrobial efficacy of glycerine esters with fatty acids of different chain length.SOFW Journal.2013,12:2-6.
[11]M Kaβ,S L(u|¨)thje,S Herweg,S Stepan.Systematic investigations in the antimicrobial efficacy of glycerine esters with fatty acids of different chain length.SOFW Journal.2013,12:2-6.
[12]H Berthele,O Sella,M Lavarde.Determination of the influence of factors(ethanol,pH and a_w)on the preservation of cosmetics using experimental design.International Journal of Cosmetic Science.2014,36,54.
[13]Fratter A,Semenzato A.New association of surfactants for the production of food and cosmetic nanoemulsions:preliminary development and characterization[J].International journal of cosmetic science,2011,33(5):443-449.
[14]Silva H D,Cerqueira MA,Vicente A A.Nanoemulsions for food applications:development and characterization[J].Food and Bioprocess Technology,2012,5(3):854-867.
[15]Lee S J,Choi S J,Li Y.Protein-stabilized nanoemulsions and emulsions:comparison of physicochemical stability,lipid oxidation,and lipase digestibility[J].Journal of agricultural and food chemistry,2010,59(1):415-427.
[16]DonsiF,Sessa M,Mediouni H.Encapsulation of bioactive compounds in nanoemulsion-based delivery systems[J].Procedia Food Science,2011,1:1666-1671.
[17]Brian Sheng Xian Teo,Mahiran Basri.A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals[J].Journal of Nanobiotechnology,2010,8:4.
[18]V.Pereira,C.Diasb,M.C.Vasconcelosa.Antibacterial activity and synergistic effects between Eucalyptus globulus leaf residues(essential oils and extracts)and antibiotics against several isolates of respiratory tractinfections(Pseudomonas aeruginosa).Industrial Crops and Products,2014,52:1-7.
[19]Abderrahmane Djouahria,Boualem Sakaa.In vitro synergistic/antagonistic antibacterial and anti-inflammatory effect of various extracts/essential oil from cones of Tetraclinisarticulata(Vahl)Masters with antibiotic and anti-inflammatory agents.Industrial Crops and Products,2014,56:60-66.
[20]JoseR.Soberon,Melina A.Sgariglia,Maria R.Dip Maderuelo.Antibacterial activities of Ligaria cuneifolia and Jodina rhombifolia leaf extracts against phytopathogenic and clinical bacteria.Journal of Bioscience and Bioengineering,2014,4:1-7.
[21]Takashi Tamura,Miwa Asahara,Mikachi Yamamoto.In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes.Microbiology and Immunology,2014,58(1).
[22]Slim Smaoui,Hajer Ben Hlima.Effects of parabens and isothiazolinone on the microbiological quality of baby shampoo:the challenge test.Biocontrol science,2012,17:135-142.
[23]S.Papageorgiou,A.Varvaresou.New alternatives to cosmetics preservation.Journal of Cosmetic Science,2010,61:107-123.
[24]Paola Ziosi,Stefano Manfredini,Alberta Vandini.Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics.Cosmetics&Toiletries,2013,128:538.
[25]Stephen Clark,Paul D.I.Fletcher,Xilin Ye.Interdroplet exchange rates of water-in-oil and oil-in-water microemulsion droplets stabilized by C_(12)E_5,Langmuir,1990,6(7):1301-1309.
[26]Paul D.I.Fletcher,Andrew M.Howe,Brian H.Robinson.The linetics of solubilisate exchange between water droplets of a water-in-oil microemulsion.J.Chem.Soc,1987,83,985-1006.