动态界面打印单分散液滴及聚合物颗粒
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- 英文论文题名：Dynamic Interfacial Printing for Uniform Droplets and Microparticles
- 论文作者：廖声茏 ; 贺泳霖 ; 王定官 ; 王亚培
- 英文论文作者：Shenglong Liao ; Yonglin He ; Dingguan Wang ; Yapei Wang ; Department of Chemistry ; Renmin University of China
- 年：2016
- 作者机构：中国人民大学化学系;
- 论文关键词：动态界面打印 ; 单分散 ; 液滴 ; 聚合物颗粒
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O631
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：205k
- 原文格式：D
- 会议级别：全国
摘要
单分散聚合物颗粒在药物可控释放、生物医学成像、光子晶体等领域因其重大应用潜力而备受关注。传统制备单分散液滴及聚合物颗粒的方法主要有乳液聚合、膜乳化法、微流控技术等,但由于以上方法存在尺寸可调范围小、均一性不足或溶剂兼容性差等问题,因而难以满足材料加工的特定需求。我们提出了一种基于动态界面剪切过程制备单分散微液滴的技术~([1,2]),可获得尺寸均一、可调范围大的液滴以及聚合物颗粒,此外,该技术工艺简便、完美地解决溶剂兼容性的问题。该技术利用Teflon管与玻璃毛细管构成内相流体的输出通道,通过并联的振动装置使毛细管出液端在外相液面上下振动,利用界面剪切实现微液滴的制备;通过控制内相流体的流速及毛细管的振动频率,可获得尺寸可调的单分散液滴;通过对液滴溶解一定浓度的聚合物,同样获得尺寸一致的单分散聚合物微球。该单分散聚合物微球在光子晶体、医学成像以及药物释放等领域有重大应用前景。
Polymeric micropaticles have attracted tremendous attention in the areas of controlled release, biomedical imaging, and photonic crystals. Traditional methods for monodisperse droplets or particles are facing with different problems such as poor uniformity or complicate micro-fabrication processes. Herein, a dynamic interfacial printing technique(DIP) is developed for preparing monodisperse droplets and polymer particles with high degree of uniformity. The DIP system is cost effective and it can be set up in a few minutes. The printing pipeline endures almost all the organic solvents, offering great promise for exploiting functional droplets or particles with long-term service.
Polymeric micropaticles have attracted tremendous attention in the areas of controlled release, biomedical imaging, and photonic crystals. Traditional methods for monodisperse droplets or particles are facing with different problems such as poor uniformity or complicate micro-fabrication processes. Herein, a dynamic interfacial printing technique(DIP) is developed for preparing monodisperse droplets and polymer particles with high degree of uniformity. The DIP system is cost effective and it can be set up in a few minutes. The printing pipeline endures almost all the organic solvents, offering great promise for exploiting functional droplets or particles with long-term service.
引文
[1]Liao,S.;He,Y.;Wang,D.;Dong,L.;Du,W.;Wang,Y.Adv.Mater.Technol.2016,1:201600021.
[2]Xu,P.;Zheng,X.;Tao,Y.;Du,W.Anal.Chem.2016,88:3171.
[2]Xu,P.;Zheng,X.;Tao,Y.;Du,W.Anal.Chem.2016,88:3171.