TR信号介导的四溴双酚A的脑发育毒性研究
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- 英文论文题名：Thyroid hormone receptor-mediated brain developmental toxicity of tetrabromobisphenol A
- 论文作者：王瑶 ; 秦占芬
- 英文论文作者：Yao Wang ; Zhan-Fen Qin ; Research Center for Eco-Environmental Sciences ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院生态环境研究中心环境化学与毒理学国家重点实验室;
- 论文关键词：TBBPA ; TR信号通路 ; 脑 ; 发育毒性
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十六分会：环境化学
- 语种：中文
- 分类号：X171.5
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十六分会 ; 环境化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：184k
- 原文格式：D
- 会议级别：全国
摘要
TBBPA是全球应用最广的溴化阻燃剂之一,主要应用于环氧树脂的加工、电子设备和建筑材料的生产,并在环境介质和人体样本中均有检出[1]。它的化学结构与甲状腺激素(TH)相似,可以通过干扰TH与其受体(TR)的结合而干扰下游TH响应基因(TH-response gene)的表达。脊椎动物脑的发育受TR信号介导的TH的调控。如果污染物具有TR信号干扰作用,可能会通过这一途径影响脑的发育。两栖动物非洲爪蟾是研究TR信号的模式生物,故而使用非洲爪蟾研究TR信号介导的TBBPA的脑发育毒性。实验使用52期非洲爪蟾蝌蚪研究TBBPA对T3诱导的脑发育的影响,58期蝌蚪研究TBBPA对变态高峰期脑发育的影响。初步结果发现,TBBPA显著抑制T3诱导的脑中ST3、TH-bzip、MMP13等TH响应基因的表达。相应地,TBBPA抑制T3诱导的脑的形态学的重塑。
TBBPA is one of the most used brominated flame retardants,in epoxy resin processing or electronic equipment and building materials production.TBBPA was detected in environmental media and human samples[1].TBBPA has similar chemical structure with TH,and it can bind TR to disrupt expression of TH-response genes.TH regulate brain development of vertebrates,so TBBPA may have toxic effect on vertebrate brain development.In this study,we investigated the effects of TBBPA on brain development during T3-induced and spontaneous Xenopus laevis metamorphosis.We found that TBBPA significantly inhibited T3-induced transcription of TH-response genes,like ST3,TH-bzip,and MMP13.Correspondingly,TBBPA inhibited T3-induced brain remodeling at the morphological level.
TBBPA is one of the most used brominated flame retardants,in epoxy resin processing or electronic equipment and building materials production.TBBPA was detected in environmental media and human samples[1].TBBPA has similar chemical structure with TH,and it can bind TR to disrupt expression of TH-response genes.TH regulate brain development of vertebrates,so TBBPA may have toxic effect on vertebrate brain development.In this study,we investigated the effects of TBBPA on brain development during T3-induced and spontaneous Xenopus laevis metamorphosis.We found that TBBPA significantly inhibited T3-induced transcription of TH-response genes,like ST3,TH-bzip,and MMP13.Correspondingly,TBBPA inhibited T3-induced brain remodeling at the morphological level.
引文
[1]Li,F.;Wang,J.;Jiang,B.;Yang,X.Environ Sci Technol.2015,49(21):12758-65.