高原低氧环境对睡眠的影响
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- 英文论文题名：Effect of high altitude hypoxia environment on sleep
- 论文作者：潘磊 ; 许文兵
- 英文论文作者：PAN Lei ; XU Wen-bing ; Department of Pulmonary Medicine ; Peking Union Medical Colledge Hospital
- 年：2016
- 作者机构：中国协和医科大学中国医学科学院;北京协和医院呼吸科;
- 论文关键词：高原 ; 睡眠紊乱 ; 急性高山病
- 英文论文关键词：high altitude ; sleep disorder ; acute maintain sickness
- 会议召开时间：2016-06-25
- 会议录名称：青藏铁路运营十周年学术研讨会卫生系统论文集
- 语种：中文
- 分类号：R339.54
- 学会代码：ZGTD
- 会议名称：青藏铁路运营十周年学术研讨会
- 会议地点：中国西藏拉萨
- 主办单位：中国铁道学会、青海省科学技术协会、西藏自治区科学技术协会
- 学会名称：中国铁道学会
- 页数：4
- 文件大小：385k
- 原文格式：O
- 会议级别：全国
摘要
目的:观察初次由平原进入高原的30名健康青年男性的睡眠状况,分析高原睡眠紊乱与急性高山病的关系。方法:通过自身对照研究,30名健康青年男性在平原及高原进行多导睡眠监测(PSG).填写急性高山病(AMS)评分表。结果:高原睡眠时间显著减少(355 22±56.02min vs 401.48±68.87min,P<0.01):睡眠期转换次数增加显著(71.51±12..60次vs53.17±15.47次,P<0.01);浅睡眠及觉醒显著增加(52.65±10.65%vs 41.92±12,45%,P<0.01),(11.38±8.43次/h vs 9.10±11.30次/上,P<0.01):深睡眠减少及快动眼睡眠显著减少(3.14±4.70%vs 11.24±7.46%,P<0.01):出现周期性呼吸,夜间血氧饱和度及呼气末CO_2显著下降(96.44±0.98%vs85.32±0.17%,P<0.01),(22.61±7.69mmHg vs 33.13±7.85mmHg,P<0,01);觉醒指数、SaO_2与AMS评分呈明显相关。结论:健康青年男性在初进高原时出现表浅、片断状睡眠,频繁周期性呼吸及严重的去氧饱和,睡眠质量下降,影响日间工作效率,睡眠紊乱与AMS的发生相关。
Objective:To investigate sleep in healthy young male who firstly go to high altitude from plain and analyze the relauonslups between high altitude sleep disorder and acute maintain sickness.Methods:Thirty subjects underwent polysomnography(PSG)and Lake Lusious score of acute mountain sickness on the plain and plateau respectively by auto-comparison study.Results:The thirty subjects had high altitude sleep disorders which manifested decreased total sleep time[355.22±36.02(m) vs 401.48±8.87(m),P<0.01],increased sleep-period interchange and superficial sleep and arouse[(71.51 4±2.60 vs 53.174±15.47,P<0.01);(52.65±10.05%vs 41.92 ±12.45%.P<0.01):(11.38±8.43.h~(-1) vs 9.10 ±11.30.h ~(-1).P<0.01)],decreased deep sleep and rapid eye movement REM) sleep(3.14±4.70%vs 11.24 ±7.46%,P<0.01),periodic breathing(PB)was observed,significantly decreased oxygen saturation(SO_2)and end-tidal carbon dioxide(ETCO_2)[(96.4±0.98%vs 85.32 ±0.17%.P<0.01);(22.61±7.69 mmHg vs 33.13±7.85 mmHg,P<0.01)].Acute mountain sickness(AMS)was significantly correlated with arousal index(AI)and arterial oxygen saturation(SaO_2) Conclusion:The healthy young people who go to plateau at the first time have light and intermittent steepness,frequent PB and serious low SO_2.Sleep quality is decreasing and it will affect working efficiency at day time.Seep disorder is related to acute mountain sickness.
Objective:To investigate sleep in healthy young male who firstly go to high altitude from plain and analyze the relauonslups between high altitude sleep disorder and acute maintain sickness.Methods:Thirty subjects underwent polysomnography(PSG)and Lake Lusious score of acute mountain sickness on the plain and plateau respectively by auto-comparison study.Results:The thirty subjects had high altitude sleep disorders which manifested decreased total sleep time[355.22±36.02(m) vs 401.48±8.87(m),P<0.01],increased sleep-period interchange and superficial sleep and arouse[(71.51 4±2.60 vs 53.174±15.47,P<0.01);(52.65±10.05%vs 41.92 ±12.45%.P<0.01):(11.38±8.43.h~(-1) vs 9.10 ±11.30.h ~(-1).P<0.01)],decreased deep sleep and rapid eye movement REM) sleep(3.14±4.70%vs 11.24 ±7.46%,P<0.01),periodic breathing(PB)was observed,significantly decreased oxygen saturation(SO_2)and end-tidal carbon dioxide(ETCO_2)[(96.4±0.98%vs 85.32 ±0.17%.P<0.01);(22.61±7.69 mmHg vs 33.13±7.85 mmHg,P<0.01)].Acute mountain sickness(AMS)was significantly correlated with arousal index(AI)and arterial oxygen saturation(SaO_2) Conclusion:The healthy young people who go to plateau at the first time have light and intermittent steepness,frequent PB and serious low SO_2.Sleep quality is decreasing and it will affect working efficiency at day time.Seep disorder is related to acute mountain sickness.
引文
[1]中华医学会呼吸病学分会,阻塞性睡眠呼吸暂停低通气综合征诊治指南[J].中华结核和呼吸杂志,2002,2(4):195-197.
[2]Sitton.Lake Louise.Consensue on difinition and quantidation of altitude illness.In:Sutton JR,Coates G.Huston CS,eds.Hypoxia and Mountain Meadicine[M].Burlington,Vermont:Quccn City Press,1992,327-330.
[3]Sutton.Effect of acetazolamide on hypoxemia during sleep at high altitude[J].N Engl J Med,1979,13,301(24):1329-1331.
[4]Wada K.Mzuguchi Y.Wada Y.Hyperlipidaemia lack of sleep and smoking as risk fectors for proteinuria among high altitude mountain trekkers[J].Nephroiogy(Carlton),2006,11(2):131-136.
[5]Kinsman TA.Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response[J].Eur J Appl Physiol,2005,94(5-6):569-575.
[6]Weil JV.Sleep at high altitude[J].High Alt Med Biol,2004,5(2):180-189.
[7]Przybylowki T,Ashirbaev A,Le Roux J.Sleep and breathing at altitude of 3800 m--the acclimatization effect Pneumonol Alergol Pol[J].2003,71(5-6):213-220.
[8]Masuyama S,Kohchiyama S,Shinozaki T.Periodic breathing at high altitude and ventilatory responses to O2 and CO2[J].Jpn J Physiol,1989,39(4):523-535.
[2]Sitton.Lake Louise.Consensue on difinition and quantidation of altitude illness.In:Sutton JR,Coates G.Huston CS,eds.Hypoxia and Mountain Meadicine[M].Burlington,Vermont:Quccn City Press,1992,327-330.
[3]Sutton.Effect of acetazolamide on hypoxemia during sleep at high altitude[J].N Engl J Med,1979,13,301(24):1329-1331.
[4]Wada K.Mzuguchi Y.Wada Y.Hyperlipidaemia lack of sleep and smoking as risk fectors for proteinuria among high altitude mountain trekkers[J].Nephroiogy(Carlton),2006,11(2):131-136.
[5]Kinsman TA.Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response[J].Eur J Appl Physiol,2005,94(5-6):569-575.
[6]Weil JV.Sleep at high altitude[J].High Alt Med Biol,2004,5(2):180-189.
[7]Przybylowki T,Ashirbaev A,Le Roux J.Sleep and breathing at altitude of 3800 m--the acclimatization effect Pneumonol Alergol Pol[J].2003,71(5-6):213-220.
[8]Masuyama S,Kohchiyama S,Shinozaki T.Periodic breathing at high altitude and ventilatory responses to O2 and CO2[J].Jpn J Physiol,1989,39(4):523-535.