手性金属有机骨架材料在毛细管电色谱分离手性药物中的应用研究
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摘要
<正>手性化合物尤其是手性药物的两个对映体通常具有不同的药物活性、作用机理和毒理作用,因此手性药物对映体的分离对手性医药开发和临床应用具有十分重要的意义。毛细管电色谱兼有毛细管电泳的高效、高分辨能力和高效液相色谱的高选择性,已广泛用于手性化合物的分离。手性金属有机骨架材料(Homochiral Metal Organic Frameworks,HMOFs)是一类金属或金属簇中心与手性有机官能团通过共价键结合形成的具有规则孔道或孔穴结构的晶态多孔材料,具有
引文
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5.C.J.Pan,W.F.Wang,X.G.Chen,In situ rapid preparation of homochiral metal-organic framework coated column for open tubular capillary electrochromatography,J.Chromatogr.A.,2016,1427:125-133
2.N.W.Ockwig,O.Delgado-Friedrichs,M.O’Keeffe,et al.,Reticular Chemistry:occurrence and taxonomy of nets and grammar for the design of frameworks,Acc.Chem.Res.,2005,38:176-182
3.Z.X.Fei,M.Zhang,J.H.Zhang,et al.,Chiral metal-organic framework used as stationary phases for capillary electrochromatography,Anal.Chim.Acta,2014,830:49-55
4.C.J.Pan,W.F.Wang,H.G.Zhang,et al.,In situ synthesis of homochiral metal-organic framework in capillary column for capillary electrochromatography enantioseparation,J.Chromatogr.A,2015,1388:207-216
5.C.J.Pan,W.F.Wang,X.G.Chen,In situ rapid preparation of homochiral metal-organic framework coated column for open tubular capillary electrochromatography,J.Chromatogr.A.,2016,1427:125-133