超分子水凝胶的构建及其用于灭血吸虫尾蚴药物缓释研究
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- 英文论文题名：Formation and Controlled Drug Release Using a Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
- 论文作者：朱磊 ; 程林秀 ; 范玉兰 ; 李勋 ; 李亿保 ; 范小林
- 英文论文作者：Lei Zhu ; Linxiu Cheng ; Yulan Fan ; Xun Li ; Yibao Li ; Xiaolin Fan ; Department of Chemistry and Chemical Engineering ; Gannan Normal University ; Department of Material and Chemical Engineering ; Pingxiang University
- 年：2016
- 作者机构：赣南师范学院化学化工学院江西省有机药物化学重点实验室;萍乡学院材料与化学工程学院;
- 论文关键词：灭尾蚴药物 ; 水凝胶 ; 药物缓释
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十六分会：环境化学
- 语种：中文
- 分类号：TQ460.1;O648.17
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十六分会 ; 环境化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：232k
- 原文格式：D
- 会议级别：全国
摘要
血吸虫病是流行于热带地区严重危害人类健康的传染病之一。血吸虫尾蚴是感染人类的唯一阶段。目前常用的灭尾蚴药物都存在着药效时间短等明显的不足,因此需要发展长效的缓释材料。超分子水凝胶凭借其三维网络结构和优良的生物相容性,作为药物缓释载体被广泛应用。[1-3]我们选用氨基酸衍生物分子为凝胶因子,构建了具有优越机械性能的水凝胶材料。[4]将灭血吸虫尾蚴药物聚醚苯酰胺负载到水凝胶中进行释放,药物缓释时间可达到一周,表明该凝胶材料可以作为抗血吸虫尾蚴药物的缓释载体。
Schistosomiasis is one of the primary and hazardous chronic infections diseases in many tropical areas.The cercarial stage has been the only cause of infection and the most fragile phase in the life cycle of schistosoma japonicum cercariae.Because of many obvious disadvantages of the short effective time in anti-cercariae for the common drugs,an efficient and sustained-release material should be developed.Supramolecular hydrogels have been widely used in controlled drug delivery,particularly due to three-dimensional self-assembled fibrillar networks and excellent biocompatibility.We select amino acid derivatives as the gelator,and fabricated a novel supramolecular hydrogel which exhibited excellent mechanical strength.The releasing time of cercaricidal drug loaded in hydrogel can up to one week,indicating that the drug-release system can be obtained.
Schistosomiasis is one of the primary and hazardous chronic infections diseases in many tropical areas.The cercarial stage has been the only cause of infection and the most fragile phase in the life cycle of schistosoma japonicum cercariae.Because of many obvious disadvantages of the short effective time in anti-cercariae for the common drugs,an efficient and sustained-release material should be developed.Supramolecular hydrogels have been widely used in controlled drug delivery,particularly due to three-dimensional self-assembled fibrillar networks and excellent biocompatibility.We select amino acid derivatives as the gelator,and fabricated a novel supramolecular hydrogel which exhibited excellent mechanical strength.The releasing time of cercaricidal drug loaded in hydrogel can up to one week,indicating that the drug-release system can be obtained.
引文
[1]Hotez,P.J.;Molyneux,D.H.;Fenwick,A.;Kumaresan,J.;Sachs,S.E.;Sachs,J.D.;Savioli,L.N.Engl.J.Med.2007,357:1018-1027.
[2]Devarakonda,B.;Hill,R.A.;Liebenberg,W.;Brits,M.;Villiers,M.M.Int.J.Pharm.2005,304:193-209.
[3]Xing,B.;Yu,C.W.;Chow,K.H.;Ho,P.L.;Fu,D.;Xu,B.J.Am.Chem.Soc.2002,124:14846-14847.
[4]Li,Y.B.;Zhu,L.;Li,Y.Y.;Cheng,L.X.;Liu,W.;Li,X.;Fan,X.L.Nanomaterials.2016,6:46
[2]Devarakonda,B.;Hill,R.A.;Liebenberg,W.;Brits,M.;Villiers,M.M.Int.J.Pharm.2005,304:193-209.
[3]Xing,B.;Yu,C.W.;Chow,K.H.;Ho,P.L.;Fu,D.;Xu,B.J.Am.Chem.Soc.2002,124:14846-14847.
[4]Li,Y.B.;Zhu,L.;Li,Y.Y.;Cheng,L.X.;Liu,W.;Li,X.;Fan,X.L.Nanomaterials.2016,6:46