可降解聚多酚包裹的介孔二氧化硅纳米颗粒在靶向可控药物递送方面的研究
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- 英文论文题名：Versatile surface engineering of porous nanomaterials with bioinspired polyphenol coatings for targeted and controlled drug delivery
- 论文作者：王丽萍 ; 李娟 ; 吴淑贤 ; 杨黄浩
- 英文论文作者：Juan Li ; Shu-Xian Wu ; Cui-Chen Wu ; Li-Ping Qiu ; Huang-Hao Yang ; College of Chemistry ; Fuzhou University
- 年：2016
- 作者机构：福州大学食品安全分析与检测技术教育部重点实验室化学学院;
- 论文关键词：介孔硅纳米颗粒 ; 聚多酚 ; 药物递送 ; 靶向
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;TQ460.4
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：141k
- 原文格式：D
- 会议级别：全国
摘要
如何实现抗肿瘤药的靶向给药和可控释放,是药物释放研究领域的焦点问题。本工作通过原位聚合的方法,制备了以生物可降解的聚多酚为包裹壳层的介孔硅纳米颗粒(MSNs),用于构建靶向可控的药物递送体系。该药物递送体系以高负载能力的MSN作为药物载体,选用自然多酚充当多功能封孔材料。聚多酚壳层不仅能防止负载药物在给药过程中的提前泄露,还能够为靶向分子(核酸适配体)提供固定平台,并且能够在细胞内的酸性环境中以及谷胱甘肽(GSH)的作用下会发生生物降解,从而实现MSNs中负载的抗癌药物的释放~([1])。因此,这种生物相容性良好的MSN药物递送体系能够实现靶向抗癌药物输送和可控药物释放,在癌症治疗方面具有良好的应用前景。
Designing smart drug delivery systems with targeted recognition and controlled release is the critical issue for researchers. Herein, we synthesized biodegradable polyphenol-coated porous nanomaterials(MSNs) for targeted and controlled drug delivery. MSNs acted as a drug carrier with high loading capability, while the polyphenol acted as multifunctional gate keeper. The polyphenol coatings not only prevented premature drug leakage, but also provided a scaffold for the immobilization of targeting moieties, such as aptamers. Besides, the polyphenol coating could be biodegraded by acidic p H and intracellular glutathione, resulting in the release of trapped anticancer drugs. As a result, these biocompatible MSNs based drug delivery systems enable for targeted drug delivery and controllable drug release, which are promising for cancer therapy.
Designing smart drug delivery systems with targeted recognition and controlled release is the critical issue for researchers. Herein, we synthesized biodegradable polyphenol-coated porous nanomaterials(MSNs) for targeted and controlled drug delivery. MSNs acted as a drug carrier with high loading capability, while the polyphenol acted as multifunctional gate keeper. The polyphenol coatings not only prevented premature drug leakage, but also provided a scaffold for the immobilization of targeting moieties, such as aptamers. Besides, the polyphenol coating could be biodegraded by acidic p H and intracellular glutathione, resulting in the release of trapped anticancer drugs. As a result, these biocompatible MSNs based drug delivery systems enable for targeted drug delivery and controllable drug release, which are promising for cancer therapy.
引文
[1]Li,J.;Wu,S.X.;Wu,C.C.,et al.,Nanoscale,2016,DOI:10.1039/C6NR00600K.