男性酒依赖患者神经心理学功能的病例对照研究
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- 英文论文题名：Case-control study of neuropsychological function in male patients with alcohol dependence
- 论文作者：郑克 ; 叶敏捷 ; 惠李 ; 郑天生 ; 潘建设 ; 黄子夜 ; 唐闻捷
- 英文论文作者：Zheng Ke ; Ye Minjie ; Hui li ; Zheng Tiansheng ; Pan Janshe ; Huang Ziye ; Tang Wenjie ; Wen Zhou Medical University
- 年：2014
- 作者机构：温州医科大学附属康宁医院;温州医科大学;温州市第七人民医院;
- 论文关键词：男性 ; 酒依赖 ; 神经心理学功能 ; 病例对照 ; 相关
- 英文论文关键词：male ; alcohol dependence ; neuropsychological function ; case-control ; correlation
- 会议召开时间：2014-11-20
- 会议录名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会论文汇编
- 语种：中文
- 分类号：R749.62
- 学会代码：ZJKX
- 会议名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会
- 会议地点：中国浙江湖州
- 主办单位：浙江省医学会精神病学分会（The Society of Psychiatry ; ZJMA）、浙江省医师协会精神科医师分会
- 学会名称：浙江省科学技术协会
- 页数：5
- 文件大小：369k
- 原文格式：O
- 会议级别：地方
摘要
目的:探讨中国男性汉族酒依赖神经心理学功能及影响因素的相关性。方法:采用重复性成套神经心理状态监测量表(repeatable battery for the assessment of neuropsychologieal status RBANS)评估30例男性酒依赖患者和30例男性对照组的神经心理学功能,比较两组间的差异。结果:1、酒依赖组与对照组相比在RBANS测试以下条目中存在显著性差异:词汇学习(F=90.27,P<0.01)、故事复述(F=14.69,P<0.01)、即刻记忆(F=46.26,P<0.01)、数字广度(F=7.21,P<0.01)、编码测试(F=36.00,P<0.01)、注意(F=22.04,P<0.01)、图形临摹(F=36.08,P<0.01)、线条定位(F=9.37,P<0.01)、视觉广度(F=37.52,P<0.01)、词语流畅性(F=16.26,P<0.01)、言语功能(F=16.67,P<0.01)、词汇回忆(F=83.00,P<0.01)、词汇再认(F=15.15,P<0.01)、故事回忆(F=12.01,P<0.01)、图形回忆(F=77.64,P<0.01)、延迟记忆(F=50.57,P<0.01)、RBANS总分(F=66.35,P<0.01)。2、相关性分析:酒依赖患者神经心理学功能相关性分析显示习惯性饮酒开始年龄与编码测试呈负相关(r=-0.364,P<0.05)、习惯性饮酒时间与线条定位呈负相关(r=-0.406,P<0.05)、成瘾时间与线条定位(r=-0.390,P<0.05)、词汇回忆(r=-0.452,P<0.05)、词汇再认呈负相关(r=-0.450,P<0.05)、总饮酒时间与词汇再认呈负相关(r=-0.41 1,P<0.05)。结论:男性酒依赖患者存在严重的神经心理学损伤。习惯性饮酒开始年龄、习惯性饮酒时间、成瘾时间、总饮酒时间对神经心理学功能存在影响。
Objective To explore the Chinese male,the han alcohol dependenceneuropsychological function and influencing factors of relevance.MethodsNeuropsychological function were assessed using the repeatable battery for the assessment of neuropsychologieal status(RBANS)in 30 male patients with alcohol dependence and 30 matched healthy controls,intergroup difference was compared and correlation analyseswere conducted for risk factors of neuropsychological impairmentin the patients.Results1:There were significant difference between the two group with RBANS in the flowing items:list learning(F=90.27,P < 0.01)、 story memory(F= 14.69,P < 0.01)、 immediate memory(F=46.26,P < 0.01)、 digit span(F=7.21,P < 0.01)、 coding(F=36.00,P < 0.01)、attention(F=22.04,P < 0.01)、 figure copy(F=36.08,P < 0.01)、 line orientation(F=9.37,P < 0.01)、 visuospatial(F=37.52,P < 0.01)、 semantic fluency(F= 16.26,P < 0.01)、 language(F= 16.67,P < 0.01)、 list recall((F=83.00,P < 0.01)、 list recognition(F=15.15,P < 0.01)、 story recall(F= 12.01,P < 0.01)、 figure recall(F=77.64,P < 0.01)、 delayed memory(F=50.57,P < 0.01)、 total score of RBANS(F=66.35,P < 0.01).2:Correlation analyses showed that the coding of the patients were negative correlated with onset age of customary drinking(r=-0.364,P < 0.05) and lineorientationwerenegative correlated with duration of customary drinking(r=-0.406,P < 0.05).duration of alcohol dependenceofthe patients werenegative correlated with lineorientation(r=-0.390,P< 0.05),list recall(r=-0.452,P < 0.05) andlist recognition(r=-0.450,P < 0.05).Years of drinking winewere negative correlated with list recognition(r=-0.411,P < 0.05).Conclusion MalePatients with alcohol dependence has serious neuropsychological impairment.neuropsychological impairment of patients was affected by onset age of customary drinking、 duration of customary drinking、 duration of alcohol dependence and years of drinking wine.
Objective To explore the Chinese male,the han alcohol dependenceneuropsychological function and influencing factors of relevance.MethodsNeuropsychological function were assessed using the repeatable battery for the assessment of neuropsychologieal status(RBANS)in 30 male patients with alcohol dependence and 30 matched healthy controls,intergroup difference was compared and correlation analyseswere conducted for risk factors of neuropsychological impairmentin the patients.Results1:There were significant difference between the two group with RBANS in the flowing items:list learning(F=90.27,P < 0.01)、 story memory(F= 14.69,P < 0.01)、 immediate memory(F=46.26,P < 0.01)、 digit span(F=7.21,P < 0.01)、 coding(F=36.00,P < 0.01)、attention(F=22.04,P < 0.01)、 figure copy(F=36.08,P < 0.01)、 line orientation(F=9.37,P < 0.01)、 visuospatial(F=37.52,P < 0.01)、 semantic fluency(F= 16.26,P < 0.01)、 language(F= 16.67,P < 0.01)、 list recall((F=83.00,P < 0.01)、 list recognition(F=15.15,P < 0.01)、 story recall(F= 12.01,P < 0.01)、 figure recall(F=77.64,P < 0.01)、 delayed memory(F=50.57,P < 0.01)、 total score of RBANS(F=66.35,P < 0.01).2:Correlation analyses showed that the coding of the patients were negative correlated with onset age of customary drinking(r=-0.364,P < 0.05) and lineorientationwerenegative correlated with duration of customary drinking(r=-0.406,P < 0.05).duration of alcohol dependenceofthe patients werenegative correlated with lineorientation(r=-0.390,P< 0.05),list recall(r=-0.452,P < 0.05) andlist recognition(r=-0.450,P < 0.05).Years of drinking winewere negative correlated with list recognition(r=-0.411,P < 0.05).Conclusion MalePatients with alcohol dependence has serious neuropsychological impairment.neuropsychological impairment of patients was affected by onset age of customary drinking、 duration of customary drinking、 duration of alcohol dependence and years of drinking wine.
引文
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[6]Rosenbloom MJ,Rohlfing T,O'Reilly AW,et al.Improvement in memory and static balance with abstinence in alcoholic men and women:selective relations with change in brain structure.Psychiatry Res,2007,155:91-102.
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[10]Tsai G,Coyle JT.The role of glutamatergic neurotransmission in the pathophysiology of alcoholism.Annu Rev Med,1998,49:173-184.
[11]Haorah J,Ramirez SH,Floreani N,et al.Mechanism of alcohol-induced oxidative stress and neuronal injury.Free Radic Biol Med,2008,45:1542-1550.
[12]Kril JJ,Homewood J.Neuronal changes in the cerebral cortex of the rat following alcohol treatment and thiamin deficiency.J Neuropathol Exp Neurol,1993,52:586-593.
[13]Campbell JA,Samartgis JR,Crowe SF.Impaired decision making on the Balloon Analogue Risk Task as a result of long-term alcohol use.J Clin Exp Neuropsychol,2013,35:1071-1081.
[14]黄燕萍.慢性酒依赖者认知功能的对照研究.中国行为医学科学,2005,14:332-333.
[15]Davies SJ,Pandit SA,Feeney A,et al.Is there cognitive impairment in clinically'healthy'abstinent alcohol dependence.Alcohol Alcohol,2005,40:498-503.
[16]Stavro K,Pelletier J,Potvin S.Widespread and sustained cognitive deficits in alcoholism:a meta-analysis.Addict Biol,2013,18:203-213.
[17]Bates ME,Bowden SC,Barry D.Neurocognitive impairment associated with alcohol use disorders:implications for treatment.Exp Clin Psychopharmacol,2002,10:193-212.
[18]Grant I.Alcohol and the brain:neuropsychological correlates.J Consult Clin Psychol,1987,55:310-324.
[19]Johnson-Greene D,Adams KM,Gilman S,et al.Effects of abstinence and relapse upon neuropsychological function and cerebral glucose metabolism in severe chronic alcoholism.J Clin Exp Neuropsychol,1997,19:378-385.
[20]Nixon SJ,Glenn SW.Cognitive psychosocial performance and recovery in female alcoholics.Recent Dev Alcohol,1995,12:287-307.
[21]Parson DA,Butters N,Nathan PE.Neuropsychology of Alcoholism:Implications for Diagnosis and Treatment.New York:Guilford Press,1987.
[22]Jones B,Parsons OA.Impaired abstracting ability in chronic alcoholics.Arch Gen Psychiatry,1971,24:71-75.
[23]Naim-Feil J,Fitzgerald PB,Bradshaw JL,et al.Neurocognitive deficits,craving,and abstinence among alcohol-dependentindividuals following detoxiEcation.Arch Clin Neuropsychol,2014,29:26-37.
[24]Smith S,Fein G.Cognitive performance in treatment-naive active alcoholics.Alcohol Clin Exp Res,2010,34:2097-2105.
[2]Sullivan EV,Pfefferbaum A.Neurocircuitry in alcoholism:a substrate of disruption and repair.Psychopharmacology(Berl),2005,180:583-594.
[3]Schrimsher G W,Parker J D.Changes in cognitive function during substance use disorder treatment.Journal of Psychopathology and Behavioral Assessment,2008,30:146-153.
[4]Allen DN,Goldstein G,Seaton BE.Cognitive rehabilitation of chronic alcohol abusers.Neuropsychol Rev,1997,7:21-39.
[5]胡建,刘薇,夏炎,等.酒依赖患者大脑萎缩的研究.中国行为医学科学,2005,14:984-997.
[6]Rosenbloom MJ,Rohlfing T,O'Reilly AW,et al.Improvement in memory and static balance with abstinence in alcoholic men and women:selective relations with change in brain structure.Psychiatry Res,2007,155:91-102.
[7]Mochizuki Y,Oishi M,Takasu T.Correlations between P300 components and regional cerebral blood flowsj Clin Neurosci,2001,8:407-410.
[8]张明岛,陈兴时.脑诱发电位学.上海:上海科技教育出版社,1995.15-68.
[9]郭崧,杜万君,王援朝,等.酒依赖者认知功能障碍的事件相关电位研究.中国药物依赖性杂志,2001,10:271-314.
[10]Tsai G,Coyle JT.The role of glutamatergic neurotransmission in the pathophysiology of alcoholism.Annu Rev Med,1998,49:173-184.
[11]Haorah J,Ramirez SH,Floreani N,et al.Mechanism of alcohol-induced oxidative stress and neuronal injury.Free Radic Biol Med,2008,45:1542-1550.
[12]Kril JJ,Homewood J.Neuronal changes in the cerebral cortex of the rat following alcohol treatment and thiamin deficiency.J Neuropathol Exp Neurol,1993,52:586-593.
[13]Campbell JA,Samartgis JR,Crowe SF.Impaired decision making on the Balloon Analogue Risk Task as a result of long-term alcohol use.J Clin Exp Neuropsychol,2013,35:1071-1081.
[14]黄燕萍.慢性酒依赖者认知功能的对照研究.中国行为医学科学,2005,14:332-333.
[15]Davies SJ,Pandit SA,Feeney A,et al.Is there cognitive impairment in clinically'healthy'abstinent alcohol dependence.Alcohol Alcohol,2005,40:498-503.
[16]Stavro K,Pelletier J,Potvin S.Widespread and sustained cognitive deficits in alcoholism:a meta-analysis.Addict Biol,2013,18:203-213.
[17]Bates ME,Bowden SC,Barry D.Neurocognitive impairment associated with alcohol use disorders:implications for treatment.Exp Clin Psychopharmacol,2002,10:193-212.
[18]Grant I.Alcohol and the brain:neuropsychological correlates.J Consult Clin Psychol,1987,55:310-324.
[19]Johnson-Greene D,Adams KM,Gilman S,et al.Effects of abstinence and relapse upon neuropsychological function and cerebral glucose metabolism in severe chronic alcoholism.J Clin Exp Neuropsychol,1997,19:378-385.
[20]Nixon SJ,Glenn SW.Cognitive psychosocial performance and recovery in female alcoholics.Recent Dev Alcohol,1995,12:287-307.
[21]Parson DA,Butters N,Nathan PE.Neuropsychology of Alcoholism:Implications for Diagnosis and Treatment.New York:Guilford Press,1987.
[22]Jones B,Parsons OA.Impaired abstracting ability in chronic alcoholics.Arch Gen Psychiatry,1971,24:71-75.
[23]Naim-Feil J,Fitzgerald PB,Bradshaw JL,et al.Neurocognitive deficits,craving,and abstinence among alcohol-dependentindividuals following detoxiEcation.Arch Clin Neuropsychol,2014,29:26-37.
[24]Smith S,Fein G.Cognitive performance in treatment-naive active alcoholics.Alcohol Clin Exp Res,2010,34:2097-2105.