构建多功能纳米载体用于光热-化疗联合治疗癌症
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- 英文论文题名：Multifunctional Nanocarriers for Combined Chemo-Photothermal Therapy
- 论文作者：张强
- 英文论文作者：Qiang Zhang ; School of Life Sciences ; East China Normal University
- 年：2016
- 作者机构：华东师范大学生命科学学院;
- 论文关键词：多模态成像 ; 光热联合化疗 ; 超小尺寸 ; 癌症治疗
- 英文论文关键词：Multimodal imaging ; chemo-photothermal therapy ; ultrasmall size ; cancer therapy
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：151k
- 原文格式：D
- 会议级别：全国
摘要
多功能纳米载体具备靶向输运、多模态成像以及协同治疗等多种功能,可以极大地提高癌症的治疗效率~([1])。但是构建多功能纳米载体通常需要多种材料组成,不仅增加了制备工艺的复杂性,而且还会带来安全性隐患~([2-4])。我们的研究目的是构建更加高效和安全的多功能纳米载体。首先,我们运用树形高分子为模板在其内部合成光热纳米材料并在其表面修饰多功能分子,该纳米载体拥有小于10纳米的超小的尺寸,不仅在近红外荧光成像的指导下可以实施靶向光热治疗癌症,而且还可以在短时间内代谢出体外,从而降低多功能纳米载体在体内滞留带来的毒性风险。我们还合成了自身具有多模态成像、光热治疗以及载药功能的纳米材料,摒弃了传统多功能纳米载体合成的复杂步骤,极大地提高了多功能纳米载体的质量和安全性,该类载体在多模态影像指导下可以实现高效的光热和化疗的联合治疗。通过以上研究,我们制备出了一系列合成方便、质量更高和安全性更高的多功能纳米载体。
Multifunctional nanocarriers(MFNCs) can simultaneously perform multiple functions including targeting delivery, multimodal imaging and combined therapies.~([1]) However, the fabrication of MFNCs requires complicated synthetic steps and various components, which causes problems including high cost, potential toxicity, and the inconsistency of dose for imaging and therapeutic modalities.~([2-4]) Here, we used dendrimer as a template to synthesize ultrasmall photothermal nanoparticles, and modified them with multiple functional groups. The synthesized MFNCs could efficiently conduct imaging-guided photothermal therapy and further were able to be quickly cleared out of the body due to their ultrasmall size. We also developed several nanomaterials that inherently possessed multiple functions including imaging, photothermal effect and drug loading ability, which avoid the complicated synthetic procedure and thus enhance the quality and biocompability of MFNCs. The in vivo studies demonstrated that MFNCs-mediated chemo-photothermal therapies could efficiently ablate tumors. Our studies developed several advanced MFNCs for more efficient and safer cancer therapy.
Multifunctional nanocarriers(MFNCs) can simultaneously perform multiple functions including targeting delivery, multimodal imaging and combined therapies.~([1]) However, the fabrication of MFNCs requires complicated synthetic steps and various components, which causes problems including high cost, potential toxicity, and the inconsistency of dose for imaging and therapeutic modalities.~([2-4]) Here, we used dendrimer as a template to synthesize ultrasmall photothermal nanoparticles, and modified them with multiple functional groups. The synthesized MFNCs could efficiently conduct imaging-guided photothermal therapy and further were able to be quickly cleared out of the body due to their ultrasmall size. We also developed several nanomaterials that inherently possessed multiple functions including imaging, photothermal effect and drug loading ability, which avoid the complicated synthetic procedure and thus enhance the quality and biocompability of MFNCs. The in vivo studies demonstrated that MFNCs-mediated chemo-photothermal therapies could efficiently ablate tumors. Our studies developed several advanced MFNCs for more efficient and safer cancer therapy.
引文
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[2]Cheng,Z.;Zaki,A.A.;Hui,J.Z.;Muzykantov,V.R.;Tsourkas,A.Science 2012,338:903.
[3]Joris,F.;Manshian,B.B.;Peynshaert,K.;De Smedt,S.C.;Braeckmans,K.;Soenen,S.J.Chem.Soc.Rev.2013,42:8339.
[4]Muhammad,F.;Guo,M.;Qi,W.;Sun,F.;Wang,A.;Guo,Y.;Zhu,G.J.Am.Chem.Soc.2011,133:8778.
[2]Cheng,Z.;Zaki,A.A.;Hui,J.Z.;Muzykantov,V.R.;Tsourkas,A.Science 2012,338:903.
[3]Joris,F.;Manshian,B.B.;Peynshaert,K.;De Smedt,S.C.;Braeckmans,K.;Soenen,S.J.Chem.Soc.Rev.2013,42:8339.
[4]Muhammad,F.;Guo,M.;Qi,W.;Sun,F.;Wang,A.;Guo,Y.;Zhu,G.J.Am.Chem.Soc.2011,133:8778.