装载姜黄素的改性壳聚糖纳米纤维膜治疗皮肤损伤的研究
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- 英文论文题名：Curcumin Loaded Poly(_(D,L)-lactide) Grafted Chitosan/PPC Composite Electrospinning Nanofibers for Enhanced Wound Healing Efficacy
- 论文作者：梅兰 ; 王跃龙 ; 范让让 ; 邓佼姣 ; 李晓玲 ; 郭刚
- 英文论文作者：Lan Mei ; Yuelong Wang ; Rangrang Fan ; Jiaojiao Deng ; Xiaoling Li ; Gang Guo ; State Key Laboratory of Biotherapy and Cancer Center ; West China Hospital ; Sichuan University ; and Collaborative Innovation Center for Biotherapy ; Department of Neurosurgery ; West China Hospital ; Sichuan University
- 年：2016
- 作者机构：四川大学华西医院生物治疗国家重点实验室;四川大学华西医院神经外科;
- 论文关键词：静电纺丝 ; 壳聚糖 ; 聚碳酸亚丙酯 ; 姜黄素 ; 皮肤损伤
- 英文论文关键词：Electrospinning ; Chitosan ; PPC ; Curcumin ; Wound healing
- 会议召开时间：2016-11-18
- 会议录名称：中国第四届静电纺丝大会（CICE 2016）摘要集
- 语种：中文
- 分类号：TQ340.64;R751
- 学会代码：ZGNM
- 会议名称：中国第四届静电纺丝大会(CICE 2016)
- 会议地点：中国北京
- 主办单位：中国复合材料学会超细纤维材料分会（筹）
- 学会名称：中关村科创纳米技术创新研究会
- 页数：1
- 文件大小：550k
- 原文格式：D
- 会议级别：全国
摘要
皮肤损伤,作为一类极具危险性和高支出的临床问题,亟须行之有效的治疗方案,对于各类创伤敷料的研制成为当今的一大研究热点[1]。静电纺丝纳米纤维膜由于其空间结构很好的模拟了细胞外基质,并且具有孔隙率高,比表面积大,透气、透水性良好,易于制备等特点,使其在制备创伤敷料方面具有显著优势[2]。壳聚糖,一种来源甲壳类动物外骨骼中的多糖,具有抗菌,抗感染等作用,被广泛用于制备各类创伤敷料[3]。但高分子量壳聚糖在常见有机溶剂中的溶解度差,限制了其应用[4]。本文用开环聚合法制备了氨基保留的D,L-聚乳酸接枝壳聚糖,改善了其溶解性,并将其与聚碳酸亚丙酯共混,采用高压静电纺丝方法制备了装载姜黄素的D,L-聚乳酸接枝壳聚糖/聚碳酸亚丙酯(PPC)共混纳米纤维。通过大鼠动物实验证实了其对皮肤损伤修复具有明显的促进作用。
Wounds, urgent healthcare problems and high cost clinical issues, are calling for efficient dressings to accelerate healing process [1]. Electrospinning is a feasible method to obtain nanofibers of which the three-dimensional structures mimics the extracellular matrix(ECM). Additionally, large porosity, nonwoven structure and proper gas permeability enable electrospinning mats to be used as wound dressings [2]. Chitosan, a polysaccharide derived from exoskeleton of crustacean, has been widely used for preparing functional wound dressings depending on its antibacteria and anti-infection properties [3]. However, poor solubility of chitosan in common organic solvents of chitosan confine its applications [4]. In this study, we grafted poly(_(D,L)-lactide) onto chitosan backbone(PDLLA-g-CS), on which poly(_(D,L)-lactide) improved its solubility, and fabricated curcumin loaded PDLLA-g-CS/Poly propylene carbonate(PPC) electrospinning nanofibers. Their enhanced wound healing efficacy has been certified.
Wounds, urgent healthcare problems and high cost clinical issues, are calling for efficient dressings to accelerate healing process [1]. Electrospinning is a feasible method to obtain nanofibers of which the three-dimensional structures mimics the extracellular matrix(ECM). Additionally, large porosity, nonwoven structure and proper gas permeability enable electrospinning mats to be used as wound dressings [2]. Chitosan, a polysaccharide derived from exoskeleton of crustacean, has been widely used for preparing functional wound dressings depending on its antibacteria and anti-infection properties [3]. However, poor solubility of chitosan in common organic solvents of chitosan confine its applications [4]. In this study, we grafted poly(_(D,L)-lactide) onto chitosan backbone(PDLLA-g-CS), on which poly(_(D,L)-lactide) improved its solubility, and fabricated curcumin loaded PDLLA-g-CS/Poly propylene carbonate(PPC) electrospinning nanofibers. Their enhanced wound healing efficacy has been certified.
引文
[1]Parani M.;Lokhande G.;Singh A.;et al.ACS Appl.Mater.Interfaces.2016,8:10049-10069.
[2]Mei L.;Wang Y.L.;Tong A.P.;et al.Expert Opin.Drug Deliv.2016,13(5):741-53.
[3]Mogos G.D.;Grumezescu A.M.Inte.J.Pharm.2014,463:127-136.
[4]Duan K.R.;Chen H.L.;Huang J.;et al.Carbohydr.Polym.2010,80:498-503.
[2]Mei L.;Wang Y.L.;Tong A.P.;et al.Expert Opin.Drug Deliv.2016,13(5):741-53.
[3]Mogos G.D.;Grumezescu A.M.Inte.J.Pharm.2014,463:127-136.
[4]Duan K.R.;Chen H.L.;Huang J.;et al.Carbohydr.Polym.2010,80:498-503.