光致亚胺交联反应构建组织整合性及生物相容性的水凝胶体系
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- 英文论文题名：Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction
- 论文作者：华宇杰 ; 林秋宁 ; 包春燕 ; 朱麟勇
- 英文论文作者：Yujie Hua ; Qiuning Lin ; Chunyan Bao ; Linyong Zhu ; Institute of Fine Chemicals ; East China University of Science and Technology
- 年：2016
- 作者机构：华东理工大学精细化工研究所;
- 论文关键词：PIC交联机制 ; 组织整合性 ; 生物相容性 ; 组织工程与再生医学
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十七分会：光化学
- 语种：中文
- 分类号：TQ427.26
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十七分会 ; 光化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：206k
- 原文格式：D
- 会议级别：全国
摘要
基于水凝胶材料在组织修复与再生方面的重要作用,我们提出了一种新型的光致亚胺交联机制,该体系的凝胶化过程是时空可控的且生物相容的,能够有效地促进水凝胶材料与组织的整合,另外,创面处的原位光交联又为组织修复的实现提供了一种更为理想的方式。如图所示,标记在高分子链上的邻硝基苄醇在365 nm光照下发生光化学反应转化为邻硝基苯甲醛,产生的醛基不仅能够快速地与带有氨基的高分子聚合物发生交联,而且能够与组织表面的氨基形成化学键粘合。在临床医学的应用中,由于光交联具有极好的时空可控性,可以满足快捷且简便的医用需求,同时,这种新颖的PIC机制具有相当好的生物相容性,并且在凝胶化的过程中能够实现与组织的粘附一体化。因此,该体系的成功构建将进一步推进作为生物医用材料的水凝胶在组织工程及再生医学领域的广泛应用。
Hydrogels have an important role in tissue repair and regeneration. In this study, we demonstrate a novel phototriggered-imine-crosslinking(PIC) reaction, which provides a gelling process with controllability, biocompatibility, and efficient tissue integration and provides an ideal method for tissue defect repair by in situ photogelling on wounds. As shown in the scheme, o-nitrosobenzaldehyde groups, converted by o-nitrobenzene upon 365 nm illumination, quickly crosslink with –NH2 in the pregelling polymers and surrounding tissue surfaces. This photo-crosslinking method provides excellent spatiotemporal controllability for quick and easy application in clinics. Meanwhile, the unique PIC mechanism exhibits excellent biocompatibility and can integrate gelation and tissue adhesion simultaneously. Therefore, the current work will take a significant step toward expediting the hydrogels widely used as important biomaterials in tissue engineering and regenerative medicine.
Hydrogels have an important role in tissue repair and regeneration. In this study, we demonstrate a novel phototriggered-imine-crosslinking(PIC) reaction, which provides a gelling process with controllability, biocompatibility, and efficient tissue integration and provides an ideal method for tissue defect repair by in situ photogelling on wounds. As shown in the scheme, o-nitrosobenzaldehyde groups, converted by o-nitrobenzene upon 365 nm illumination, quickly crosslink with –NH2 in the pregelling polymers and surrounding tissue surfaces. This photo-crosslinking method provides excellent spatiotemporal controllability for quick and easy application in clinics. Meanwhile, the unique PIC mechanism exhibits excellent biocompatibility and can integrate gelation and tissue adhesion simultaneously. Therefore, the current work will take a significant step toward expediting the hydrogels widely used as important biomaterials in tissue engineering and regenerative medicine.
引文
[1]Yang,Y.L.;Zhang,J.Y.;Liu,Z.Z.;Lin,Q.N.;Liu,X.L.;Bao,C.Y.;Wang,Y.;Zhu,L.Y.Adv.Mater.2016,28(14),2724.
[2]Liu,Z.Z.;Liu,T.;Lin,Q.N.;Bao,C.Y.;Zhu,L.Y.Angew.Chem.Int.Ed.2015,54(1),174.
[3]Liu,Z.Z.;Lin,Q.N.;Sun,Y.;Liu,T.;Bao,C.Y.;Li,F.Y.;Zhu,L.Y.Adv.Mater.2014,26(23),3912.
[2]Liu,Z.Z.;Liu,T.;Lin,Q.N.;Bao,C.Y.;Zhu,L.Y.Angew.Chem.Int.Ed.2015,54(1),174.
[3]Liu,Z.Z.;Lin,Q.N.;Sun,Y.;Liu,T.;Bao,C.Y.;Li,F.Y.;Zhu,L.Y.Adv.Mater.2014,26(23),3912.