可激活长余辉光学探针指导的肿瘤光热治疗
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- 英文论文题名：A Persistent Luminescence Nanoparticles Based Activatable Probe for in vivo Optical Imaging-Guided Photothermal Cancer Therapy
- 论文作者：陈丽建 ; 杨成雄 ; 严秀平
- 英文论文作者：Li-jian Chen ; Cheng-Xiong Yang ; Xiu-Ping Yan ; College of Chemistry ; State Key Laboratory of Medicinal Chemical Biology ; Tianjin Key Laboratory of Molecular Recognition and Biosensing ; Nankai University ; Collaborative Innovation Center of Chemical Science and Engineering
- 年：2016
- 作者机构：南开大学化学学院,药物化学生物学国家重点实验室,天津市生物传感与分子识别重点实验室;天津化学化工协同创新中心;
- 论文关键词：长余辉纳米粒子 ; 硫化铜纳米粒子 ; 可激活光学探针 ; 光热治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;R730.5
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：150k
- 原文格式：D
- 会议级别：全国
摘要
通过水热-低温煅烧的方法合成长余辉纳米粒子[1,2],通过酰胺缩合在长余辉纳米粒子表面修饰多肽,利用金属-巯基键将硫化铜纳米粒子连接到多肽末端,长余辉与硫化铜纳米粒子之间发生F?ster共振能量转移,从而形成背景较低的长余辉-硫化铜光学纳米探针。另外,基质金属蛋白酶高表达的肿瘤微环境,可以特异性切断连接长余辉-硫化铜复合探针之间的多肽,从而激活长余辉磷光,进而利用硫化铜纳米粒子的近红外吸收进行肿瘤的光热治疗。
Persistent luminescence nanoparticles(PLNP) were synthesized by hydrothermal method and low-temperature sintering in air. A peptide was conjugated on the surface of PLNP via amide condensation. Copper sulfide(Cu S) nanoparticles were linked to the peptide terminal through metal-thiol bond to design a low optical background nanoprobe of PLNP-Cu S based on F?ster resonance energy transfer effect. Moreover, under metal matrix proteinase-rich tumor microenvironment, the linked peptide was specifically broken and the luminescence of nanoprobe was activated to achieve turn-on luminescence imaging. In addition, the nanoprobe allowed effective photothermal therapy due to the excellent near-infrared absorption of Cu S nanoparticles.
Persistent luminescence nanoparticles(PLNP) were synthesized by hydrothermal method and low-temperature sintering in air. A peptide was conjugated on the surface of PLNP via amide condensation. Copper sulfide(Cu S) nanoparticles were linked to the peptide terminal through metal-thiol bond to design a low optical background nanoprobe of PLNP-Cu S based on F?ster resonance energy transfer effect. Moreover, under metal matrix proteinase-rich tumor microenvironment, the linked peptide was specifically broken and the luminescence of nanoprobe was activated to achieve turn-on luminescence imaging. In addition, the nanoprobe allowed effective photothermal therapy due to the excellent near-infrared absorption of Cu S nanoparticles.
引文
[1]T Maldiney,A Bessière,et al.Nature Mater.2014,13:418.
[2]M Allix,S Chenu,et al.Chem.Mater.2013,25:1600.
[2]M Allix,S Chenu,et al.Chem.Mater.2013,25:1600.