功能纳米材料在肿瘤放疗中的应用
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- 英文论文题名：Functional nanomaterials in tumor radiotherapy applications
- 论文作者：杨凯
- 英文论文作者：Kai Yang ; School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X) ; Soochow University
- 年：2016
- 作者机构：苏州大学放射医学与防护学院&放射医学及交叉学科研究院;
- 论文关键词：功能纳米材料 ; SPECT成像 ; 光热治疗 ; 放化疗 ; 协同治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：R730.5;TB383.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：207k
- 原文格式：D
- 会议级别：全国
摘要
放射治疗(Radiotherapy)是临床肿瘤治疗的一个重要手段,主要包括内照射(利用放射性核素)和外照射(利用X光等外辐照源)两种方式。本课题组在最近的工作中,我们将放射性核素I-131通过标记或者掺杂的方式标记到功能纳米材料上(纳米石墨烯、硫化铜)。利用纳米材料在近红外区的强吸收以及放射性核素,实现肿瘤核素成像指导下的肿瘤光热治疗与放疗协同治疗。此外,我们制备生物相容性聚多巴胺纳米颗粒,利用其表面的不同作用机制,我们可以同时将能够进行SPECT显像的~(99m)Tc(γ衰变核素)和具有放射治疗功能的I-131(β衰变核素)标记到聚多巴胺颗粒上,在此基础上我们进一步将化疗药物阿霉素装载到纳米颗粒表面,设计出了一种诊疗一体化纳米载药系统,用于小鼠肿瘤模型的放疗与化疗的联合治疗,在降低放化疗药物剂量从而有效降低全身系统性毒副作用的同时增强了治疗效果。
Radiotherapy is an important means of clinical tumor treatment, including internal exposure(using radioactive nuclide) and external beam radiation source(using X-ray). In our recent work, we labeled/doped nanomaterials(e.g. nano-graphene and copper sulfide) with radionuclide I-131. Utilizing the intrinsic high near infrared absorbance of nanomaterials and labeled radionuclide, we performed tumor nuclear imaging guided combination of photothermal therapy and radiotherapy of cancer. In addition, biocompatible polydopamine nanoparticles were prepared and labeled with radionuclide 99 mT c for SPECT imaging and I-131 for radiotherapy. Moreover, we also loaded anticancer drug, doxorubicin(DOX) onto the surface of polydopamine nanoparticles for chemotherapy of cancer, realizing combined radioisotope therapy and chemotherapy of cancer and reducing the side effects to treated animals.
Radiotherapy is an important means of clinical tumor treatment, including internal exposure(using radioactive nuclide) and external beam radiation source(using X-ray). In our recent work, we labeled/doped nanomaterials(e.g. nano-graphene and copper sulfide) with radionuclide I-131. Utilizing the intrinsic high near infrared absorbance of nanomaterials and labeled radionuclide, we performed tumor nuclear imaging guided combination of photothermal therapy and radiotherapy of cancer. In addition, biocompatible polydopamine nanoparticles were prepared and labeled with radionuclide 99 mT c for SPECT imaging and I-131 for radiotherapy. Moreover, we also loaded anticancer drug, doxorubicin(DOX) onto the surface of polydopamine nanoparticles for chemotherapy of cancer, realizing combined radioisotope therapy and chemotherapy of cancer and reducing the side effects to treated animals.
引文
[1].Zhong X,Yang K.*,Liu Z.*,Adv.Funct.Mater.2015,25,7327–7336.
[2].Yi X.;Yang K*;Liu Z.*,Adv.Funct.Mater.2015,25(29),4689-4699.
[3].Chen L.;Liu Z.*;Yang K*,Biomaterials,2015,66,21-28.
[4].Li M.;Liu Z.*;Yang K.*,ACS Appl.Mater.Interfaces,2016,DOI:10.1021/acsami.5b11588
[2].Yi X.;Yang K*;Liu Z.*,Adv.Funct.Mater.2015,25(29),4689-4699.
[3].Chen L.;Liu Z.*;Yang K*,Biomaterials,2015,66,21-28.
[4].Li M.;Liu Z.*;Yang K.*,ACS Appl.Mater.Interfaces,2016,DOI:10.1021/acsami.5b11588