曲美他嗪治疗冠心病PCI术后心绞痛的疗效观察
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- 英文论文题名：Efficacy observation of Trimetazidine for the treatment of angina pectoris after coronary heart disease PCI operation
- 论文作者：朱瑞英
- 英文论文作者：ZHU Ruiying ; Department of General Practice ; Chaoyang District Zuojiazhuang Community Health Service Center
- 年：2017
- 作者机构：北京市朝阳区左家庄社区卫生服务中心全科;
- 论文关键词：曲美他嗪 ; 冠心病PCI术 ; 心绞痛
- 英文论文关键词：Trimetazidine ; Coronary heart disease PCI operation ; Angina pectoris
- 会议召开时间：2017-05-26
- 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
- 语种：中文
- 分类号：R541.4
- 学会代码：ZHXB
- 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
- 会议地点：中国湖北武汉
- 主办单位：《中国组织化学与细胞化学杂志》社有限公司
- 学会名称：《中国组织化学与细胞化学杂志》社有限公司
- 页数：2
- 文件大小：244k
- 原文格式：O
- 会议级别：全国
摘要
目的:探讨曲美他嗪治疗冠心病PCI术后心绞痛的疗效并进行分析。方法:选择2014年3月至2016年3月来本院就诊的冠心病PCI术后心绞痛患者80例,随机分为两组,每组40例。对照组给予常规治疗,观察组在对照组的基础上加用曲美他嗪口服。治疗4周后,对两组患者的疗效、血清肌钙蛋白I(cTnI)、高敏C-反应蛋白(hs-CRP)水平和心功能指标进行比较和分析。结果:治疗4周后观察组的总有效率为90%,显著高于对照组(77.5%),差异具有统计学意义(x~2=5.741,P<0.05);治疗4周后观察组的血清cTnI和hs-CRP水平均显著低于对照组,差异具有统计学意义(t=4.185、6.736,P<0.05);治疗后观察组的左心室射血分数显著高于对照组,而左心室舒张末期内径显著低于对照组,差异具有统计学意义(t=2.134,2.082,P<0.05)。结论:曲美他嗪治疗冠心病PCI术后心绞痛疗效显著,大幅减轻患者心肌损伤,改善其心脏功能,值得临床推广。
Objective:To explore the efficacy observation of sibutramine Trimetazidine for the treatment of angina pectoris after coronary heart disease PCI operation.Methods:80 patients with angina pectoris after coronary heart disease PCI operation received in our hospital from Mar 2014 to Mar 2016 were randomly divided into two groups,with 40 cases in each group.The control group was given conventional treatment,and the observation group was given trimetazidine based on the control group.The efficacy,serum cardiac troponin I(cTnI),serum C-reactive protein(hs-CRP) levels and cardiac function indicators of the two groups of patients were compared after 4 weeks of treatment.Result:The total effective rate in the observation group was 90%after 4 weeks of treatment,significantly higher than the control group(77.5%),the difference was statistically significant(χ~2 = 5.741,P <0.05):The levels of serum cTnl and hs-CRP in the observation group were significantly lower than those in the control group,and the differences were statistically significant(t = 4.185,6.736,P < 0.05):The left ventricular ejection fraction of the observation group was significantly higher than that of the control group,while the left ventricular end diastolic diameter was significantly lower than the control group,the differences were statistically significant(t = 2.134,2.082,P < 0.05).Conclusions Trimetazidine for the treatment of angina pectoris after coronary heart disease PCI operation got curative effect,significantly reduced the myocardial injury of patients,and improved the heart function of patients,worthy of clinical promotion.
Objective:To explore the efficacy observation of sibutramine Trimetazidine for the treatment of angina pectoris after coronary heart disease PCI operation.Methods:80 patients with angina pectoris after coronary heart disease PCI operation received in our hospital from Mar 2014 to Mar 2016 were randomly divided into two groups,with 40 cases in each group.The control group was given conventional treatment,and the observation group was given trimetazidine based on the control group.The efficacy,serum cardiac troponin I(cTnI),serum C-reactive protein(hs-CRP) levels and cardiac function indicators of the two groups of patients were compared after 4 weeks of treatment.Result:The total effective rate in the observation group was 90%after 4 weeks of treatment,significantly higher than the control group(77.5%),the difference was statistically significant(χ~2 = 5.741,P <0.05):The levels of serum cTnl and hs-CRP in the observation group were significantly lower than those in the control group,and the differences were statistically significant(t = 4.185,6.736,P < 0.05):The left ventricular ejection fraction of the observation group was significantly higher than that of the control group,while the left ventricular end diastolic diameter was significantly lower than the control group,the differences were statistically significant(t = 2.134,2.082,P < 0.05).Conclusions Trimetazidine for the treatment of angina pectoris after coronary heart disease PCI operation got curative effect,significantly reduced the myocardial injury of patients,and improved the heart function of patients,worthy of clinical promotion.
引文
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[7]韩全乐,刘晓堃,张琦,等.早发冠心病患者理想心血管健康行为和因素研究.中国动脉硬化杂志,2014,22(12):1268-1272.
[8]吴妍,许杜娟,王静,等.中国汉族冠心病患者ABCB1 C3435T多态性与氯吡格雷抗血小板作用相关性的Meta分析.中国医院药学杂志,2016,36(3):210-215.
[9]刘静,安尼瓦尔·阿不里孜,黄定.629例冠心病患者经PCI术血运重建后12个月随访分析.新疆医科大学学报,2014,10:1315-1317.
[10]Biering K,Andersen JH,Lund T,et al.Psychosocial Working Environment and Risk of Adverse Cardiac Events in Patients Treated for Coronary Heart Disease.J Occup Rehabil,2015,25(4):770-775.
[11]林铜梅,李中华.曲美他嗪对冠状动脉介入术后心绞痛患者的疗效及运动耐量的影响.中国综合临床,2012,28(3):274-276.
[12]王志方,张芙成,苏淑红,等.曲美他嗪对稳定性劳力型心绞痛患者运动耐量的影响.中国误诊学杂志,2010,10(28):6882.
[13]李峰,武传章,刘霞.心肌肌钙蛋白Ⅰ(cTnI).CRP.CK-MB联合检测在急性心肌梗死诊断中的价值.医学检验与临床,2008,19(6):80.
[14]赖仁奎,盛小刚,潘光明.冠心病心力衰竭中医证型与NT-proBNP、hs-CRP、cTnl的相关性研究.中西医结合心脑血管病杂志,2016,14(3):320-322.
[15]凌琳,承艳,康丽娜,等.冠心病患者血清高敏C反应蛋白和Periostin蛋白与冠动脉病变严重程度的相关性.中国动脉硬化杂志,2013,21(5):440-444.
[16]宋奎全,张恒龙,陈柏楠.炎性因子与动脉硬化闭塞症中医证型相关性研究.中国中西医结合外科杂志,2016,22(4):315-317.
[17]万招飞,张娇,薛嘉虹,等.冠心病患者动脉弹性与血清高敏C反应蛋白和基质金属蛋白酶9的相关性.中国动脉硬化杂志,2012,20(11):1003-1006.
[18]闻加升,于宗良,谷慧敏,等.老年冠心病患者血清炎症因子、基质金属蛋白酶-9、尿酸、胱抑素C水平变化.中国老年学杂志,2016,36(21):5275-5277.
[2]Rothenbacher D,Jaensch A,Mons U,et al.Prognostic value of oneyear course of symptoms of anxiety and depression in patients with coronary heart disease:Role of physical activity and unmet medical need.Eur J Prev Cardiol,2015,22(9):1129-1138.
[3]Yang J,Yang X,Liu W,et al.Effects of percutaneous coronary intervention on the ambulatory blood pressure of patients with hypertension and coronary heart disease.Ir J Med Sci,2015,184(4):845-850.
[4]Gaglia MA Jr,Torguson R,Lipinski MJ,et al.Frequency of angina pectoris after percutaneous coronary intervention and the effect of metallic stent type.Am J Cardiol,2016,117(4):526-531.
[5]Hao J,Du H,Li WW,et al.Effects of atorvastatin combined with trimetazidine on myocardial injury and inflammatory mediator in unstable angina patients during perioperative of percutaneous coronary intervention.Eur Rev Med Pharmacol Sci,2015,19(23):4642-4646.
[6]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.慢性稳定性心绞痛诊断与治疗指南.中华心血管病杂志,2007,35(3):195-206.
[7]韩全乐,刘晓堃,张琦,等.早发冠心病患者理想心血管健康行为和因素研究.中国动脉硬化杂志,2014,22(12):1268-1272.
[8]吴妍,许杜娟,王静,等.中国汉族冠心病患者ABCB1 C3435T多态性与氯吡格雷抗血小板作用相关性的Meta分析.中国医院药学杂志,2016,36(3):210-215.
[9]刘静,安尼瓦尔·阿不里孜,黄定.629例冠心病患者经PCI术血运重建后12个月随访分析.新疆医科大学学报,2014,10:1315-1317.
[10]Biering K,Andersen JH,Lund T,et al.Psychosocial Working Environment and Risk of Adverse Cardiac Events in Patients Treated for Coronary Heart Disease.J Occup Rehabil,2015,25(4):770-775.
[11]林铜梅,李中华.曲美他嗪对冠状动脉介入术后心绞痛患者的疗效及运动耐量的影响.中国综合临床,2012,28(3):274-276.
[12]王志方,张芙成,苏淑红,等.曲美他嗪对稳定性劳力型心绞痛患者运动耐量的影响.中国误诊学杂志,2010,10(28):6882.
[13]李峰,武传章,刘霞.心肌肌钙蛋白Ⅰ(cTnI).CRP.CK-MB联合检测在急性心肌梗死诊断中的价值.医学检验与临床,2008,19(6):80.
[14]赖仁奎,盛小刚,潘光明.冠心病心力衰竭中医证型与NT-proBNP、hs-CRP、cTnl的相关性研究.中西医结合心脑血管病杂志,2016,14(3):320-322.
[15]凌琳,承艳,康丽娜,等.冠心病患者血清高敏C反应蛋白和Periostin蛋白与冠动脉病变严重程度的相关性.中国动脉硬化杂志,2013,21(5):440-444.
[16]宋奎全,张恒龙,陈柏楠.炎性因子与动脉硬化闭塞症中医证型相关性研究.中国中西医结合外科杂志,2016,22(4):315-317.
[17]万招飞,张娇,薛嘉虹,等.冠心病患者动脉弹性与血清高敏C反应蛋白和基质金属蛋白酶9的相关性.中国动脉硬化杂志,2012,20(11):1003-1006.
[18]闻加升,于宗良,谷慧敏,等.老年冠心病患者血清炎症因子、基质金属蛋白酶-9、尿酸、胱抑素C水平变化.中国老年学杂志,2016,36(21):5275-5277.