叶酸、维生素B12和多奈哌齐治疗HHcy阿尔茨海默病的对照研究
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- 英文论文题名：Reaserch on the combination of folic acid,vitamin B12 and Donepezil in therapy of Alzheimer's disease HHcy
- 论文作者：支胜利 ; 陈科 ; 潘新根 ; 陈静 ; 吴杰
- 英文论文作者：Zhi Shengli ; Chen Ke ; Pan Xingen ; Department of senile psychiatry ; the Thirth People's Hospital of Huzhou
- 年：2014
- 作者机构：浙江省湖州市第三人民医院老年精神科;
- 论文关键词：叶酸 ; 维生素B12 ; 多奈哌齐 ; 阿尔茨海默病 ; 认知功能 ; 行为能力 ; Hcy
- 英文论文关键词：Folic acid ; Vitamin B12 ; Donepezil ; Alzhemiers desease ; Cognitiv function ; Behaivier abilities ; Homocysteine
- 会议召开时间：2014-11-20
- 会议录名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会论文汇编
- 语种：中文
- 分类号：R749.16
- 学会代码：ZJKX
- 会议名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会
- 会议地点：中国浙江湖州
- 主办单位：浙江省医学会精神病学分会（The Society of Psychiatry ; ZJMA）、浙江省医师协会精神科医师分会
- 学会名称：浙江省科学技术协会
- 页数：4
- 文件大小：356k
- 原文格式：O
- 会议级别：地方
摘要
目的探讨叶酸、维生素B12和多奈哌齐对高同型半胱氨酸血症(HHcy)阿尔茨海默病患者的影响。方法收集高同型半胱氨酸血症阿尔茨海默病患者100例,依就诊顺序随机分为3个组,叶酸、维生素B12和多奈哌齐联合治疗组34例,多奈哌齐治疗组33例,空白对照组33例。空白对照组不使用治疗痴呆药物。3组患者分别在治疗前和治疗3月后进行MM S E评分、AD L评分、Hcy浓度的测评。结果叶酸、维生素B12和多奈哌齐联合治疗组MM S E评分减分值(6.47±2.11)明显高于多奈哌齐治疗组(4.60±2.04)(P<0.01)和空白对照组(2.50±1.52)(P<0.01);叶酸、维生素B12和多奈哌齐联合治疗组A D L评分减分值(4.90±2.01)明显高于安理申治疗组(3.77±1.87)(P=0.03)和空白对照组(2.40±1.65)(P<0.01);叶酸、维生素B12和多奈哌齐联合治疗组血浆Hcy浓度减分值(5.63±2.89)明显高于多奈哌齐治疗组(4.00±2.72)(P=0.03)和空白对照组(2.40±1.65)(P<0.01)。AD患者MM S E减分值与Hcy浓度减分值呈正相关(r=0.423,P<0.01);ADL减分值与Hcy浓度减分值呈正相关(r=0.240,P<0.05).三组均未出现明显不良反应。结论叶酸、维生素B12和多奈哌齐联合治疗对高同型半胱氨酸血症(HHcy)阿尔茨海默病患者认知、行为能力有显著改善作用,Hcy浓度降低明显。
Objective To evaluate the effect on folic acid,vitamin B12 and donepezil in the treatment of Alzheimer's disease HHcy.Methods Totally 100 patients with Alzheimer s disease HHcy were randomly divided into 3 groups:the group treated with the combination of folic acid,vitamin B12 and donepezil(34cases),the group treated with donepezil(33 cases),and the control group without any madicine to prevent Alzheimer s disease(33 cases).MMSE scale and ADL scale of the three groups were assessed before treatment and 3 months after treatment.Result The decreased score of MMSE of the group treated with folic acid,vitamin B12 and donepezil(6.47 ± 2.11) were markedly higher than that of donepezil group(4.60 ± 2.04)(P < 0.01) and the control group(2.50 ± 1.52)(P < 0.01).The decreased score of ADL of the group treated with folic acid,vitamin B12 and donepezil(4.90 ± 2.01) were markedly higher than that of donepezil group(3.77 ± 1.87)(P =0.03)and the control group(2.40 ± 1.65)(P < 0.01).The decreased score of Hcy concentration of the group treated with folic acid,vitamin B12 and donepezil(5.63 ± 2.89) were markedly higher than that of donepezil group(4.00 ± 2.72)(P =0.03)and the control group(2.40 ± 1.65)(P < 0.01).The decreased score of MMSE and Hcy concentration was positively correlated(r=0.423,P < 0.01).The decreased score of ADL and Hcy concentration was positively correlated(r=0.240,P < 0.05).Three groups did not appear harmful response(P < 0.01).Conclusions Congnitive function and behavioral abilities were markbly improved treated with the conbination of folic acid,vitamin B12 and donepezil to Alzheimers s desease HHcy.The Hcy concentration decreased significantly.
Objective To evaluate the effect on folic acid,vitamin B12 and donepezil in the treatment of Alzheimer's disease HHcy.Methods Totally 100 patients with Alzheimer s disease HHcy were randomly divided into 3 groups:the group treated with the combination of folic acid,vitamin B12 and donepezil(34cases),the group treated with donepezil(33 cases),and the control group without any madicine to prevent Alzheimer s disease(33 cases).MMSE scale and ADL scale of the three groups were assessed before treatment and 3 months after treatment.Result The decreased score of MMSE of the group treated with folic acid,vitamin B12 and donepezil(6.47 ± 2.11) were markedly higher than that of donepezil group(4.60 ± 2.04)(P < 0.01) and the control group(2.50 ± 1.52)(P < 0.01).The decreased score of ADL of the group treated with folic acid,vitamin B12 and donepezil(4.90 ± 2.01) were markedly higher than that of donepezil group(3.77 ± 1.87)(P =0.03)and the control group(2.40 ± 1.65)(P < 0.01).The decreased score of Hcy concentration of the group treated with folic acid,vitamin B12 and donepezil(5.63 ± 2.89) were markedly higher than that of donepezil group(4.00 ± 2.72)(P =0.03)and the control group(2.40 ± 1.65)(P < 0.01).The decreased score of MMSE and Hcy concentration was positively correlated(r=0.423,P < 0.01).The decreased score of ADL and Hcy concentration was positively correlated(r=0.240,P < 0.05).Three groups did not appear harmful response(P < 0.01).Conclusions Congnitive function and behavioral abilities were markbly improved treated with the conbination of folic acid,vitamin B12 and donepezil to Alzheimers s desease HHcy.The Hcy concentration decreased significantly.
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