基于膜乳化法构建的纳米农药载药系统
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- 英文论文题名：Fabrication of Uniform Microspheres/Microcapsules by Premix Membrane Emulsification for Controlled Release of Pesticides
- 论文作者：刘宝霞 ; 李丹 ; 吴德成 ; Sijia Xu
- 英文论文作者：Baoxia Liu ; Dan Li ; Sijia Xu ; Decheng Wu ; Institute of Chemistry ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院化学研究所;
- 论文关键词：快速膜乳化 ; 农药纳米化 ; 淀粉微胶囊 ; 聚乳酸微胶囊 ; 绿色农药
- 会议召开时间：2016-07-02
- 会议录名称：中国化学会第30届学术年会摘要集-论坛三：化学与农业交叉论坛
- 语种：中文
- 分类号：TQ450.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-论坛三 ; 化学与农业交叉论坛
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：148k
- 原文格式：D
- 会议级别：全国
摘要
发展高效、安全的绿色农药,是保障国家粮食、食品与生态安全的重大战略需求,对于缓解我国当前的农药残留与环境污染、促进农药产业的可持续发展具有重要意义。采用纳米材料与技术,发展纳米载药系统,改善农药剂型功能,是提高农药有效性及安全性的重要科学手段。膜乳化技术制备的微粒尺寸均一、包封率高、稳定性好,乳化过程能耗较低、条件温和,适宜生物活性物质的包埋和纳米载体的量产化制备。本报告将介绍我们采用快速膜乳化方法构建纳米农药载体并研究了载体的结构、粒径、表面形貌、表面羧基化等特性对其药物可控释放、分散性、叶面亲和性、稳定性等性质的影响。通过选用低成本的淀粉和聚乳酸为载体材料,结合不同乳化方法构建了阿维菌素/淀粉微胶囊、高效氯氟氰菊酯聚乳酸微胶囊和氯虫苯甲酰胺聚乳酸多孔微胶囊等载药体系。生测结果证实了这些载药体系的杀虫效果与相应的商用剂型相当,已开展田间药效评价系统评估纳米载药体系的生物利用率和安全性。
Development of efficient and safe green pesticide is of the major strategic needs for national food and ecological security. Advanced nanotechnology is an important approach to improve the formulation for enhancing effectiveness and safety of the pesticide. Membrane emulsification technology can facilely produce uniform microparticles with high encapsulation efficiency, good stability and low energy consumption, and it is suitable for encapsulation of bioactive agents and huge production of nanocarriers. In this report, we choose low-cost starch and polylactic acid to construct a series of uniform microspheres, microcapsules and porous microcapsules via premix membrane emulsification for developing environment-friendly controlled-release drug systems for delivery of avermectin, cyfluthrin and chlorantraniliprole. These systems with good UV and thermal stability yielded sustained release of pesticides for a longer period and the similar efficacy as the commercial formulation. Such environmentally friendly novel pesticide formulations should be greatly potential for wide applications in the field of agriculture.
Development of efficient and safe green pesticide is of the major strategic needs for national food and ecological security. Advanced nanotechnology is an important approach to improve the formulation for enhancing effectiveness and safety of the pesticide. Membrane emulsification technology can facilely produce uniform microparticles with high encapsulation efficiency, good stability and low energy consumption, and it is suitable for encapsulation of bioactive agents and huge production of nanocarriers. In this report, we choose low-cost starch and polylactic acid to construct a series of uniform microspheres, microcapsules and porous microcapsules via premix membrane emulsification for developing environment-friendly controlled-release drug systems for delivery of avermectin, cyfluthrin and chlorantraniliprole. These systems with good UV and thermal stability yielded sustained release of pesticides for a longer period and the similar efficacy as the commercial formulation. Such environmentally friendly novel pesticide formulations should be greatly potential for wide applications in the field of agriculture.
引文
[1]Liu,B.X.;Wang,Y.;Yang,F.;Wang,X.;Shen,H.;Cui,H.X.;Wu,D.C.Colloids Surf.B.DOI.10.1016/j.colsurfb.2016.03.084.
[2]Li,D.;Liu,B.X.;Yang,F.;Wang,X.;Shen,H.;Wu,D.C.Carbohyd.Polym.2016,136:341.
[2]Li,D.;Liu,B.X.;Yang,F.;Wang,X.;Shen,H.;Wu,D.C.Carbohyd.Polym.2016,136:341.