血浆中类二十烷酸代谢产物分析
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摘要
<正>肿瘤的发病率和死亡率呈现增加的趋势,已成为威胁人们健康的重大疾病,寻找肿瘤诊断和疗效判断的标志物对病人康复极为重要[1]。代谢组学作为一种研究生物体内代谢途径的方法,可以对肿瘤发生发展过程中的代谢产物进行定性与定量分析,有利于肿瘤标记物的筛选,从而实现肿瘤的早期诊断和治疗[2]。类二十烷酸代谢产物来源于多不饱和脂肪酸,参与炎症的促进和抑制过程,从而影响肿瘤的发生发展[3,4]。
引文
1.Torre LA,Bray F,Siegel RL,et al:Global cancer statistics,2012.CA:a cancer journal for clinicians 2015,65(2):87-108
2.Ni Y,Xie G,Jia W:Metabonomics of human colorectal cancer:new approaches for early diagnosis and biomarker discovery.Journal of proteome research 2014,13(9):3857-3870
3.Dennis EA,Norris PC:Eicosanoid storm in infection and inflammation.Nature reviews Immunology 2015,15(8):511-523
4.Patterson AD,Maurhofer O,Beyoglu D,et al:Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling.Cancer research 2011,71(21):6590-6600
2.Ni Y,Xie G,Jia W:Metabonomics of human colorectal cancer:new approaches for early diagnosis and biomarker discovery.Journal of proteome research 2014,13(9):3857-3870
3.Dennis EA,Norris PC:Eicosanoid storm in infection and inflammation.Nature reviews Immunology 2015,15(8):511-523
4.Patterson AD,Maurhofer O,Beyoglu D,et al:Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling.Cancer research 2011,71(21):6590-6600