肿瘤微环境响应性探针的构筑与联合化疗研究
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- 英文论文题名：Fabrication of Tumor Microenvironment Responsive Nanoparticles for Combination Chemotherapy
- 论文作者：胡祥龙 ; 翟少东
- 英文论文作者：Xianglong Hu ; Shaodong Zhai ; Ministry of Education Key Laboratory of Laser Life Science ; College of Biophotonics ; South China Normal University
- 年：2016
- 作者机构：华南师范大学激光生命科学教育部重点实验室生物光子学研究院;
- 论文关键词：肿瘤微环境 ; 氧化还原响应性 ; 核交联 ; 联合化疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：287k
- 原文格式：D
- 会议级别：全国
摘要
利用结构优化的含硒两亲性高分子作为多种化疗药物联合传输的载体;在可见光照射下,该纳米粒子可以发生原位核交联,从而提高血液循环中纳米药物的稳定性,避免药物的泄露,降低副作用。在肿瘤的氧化还原微环境中可以高效释放多种化疗药物,细胞实验和活体实验研究表明,该纳米药物具有较好的肿瘤抑杀能力。
We report on diselenide-rich amphiphilic triblock copolymers with optimized components to fabricate combined drug delivery systems. Traceless core crosslinking was performed upon visible light irradiation for these nanoparticles, which significantly improve their physiological stability and avoid side effects due to minimal premature drug leakage during blood circulation. Whereas, efficient combined drug release were observed in tumors' redox microenvironments. In vitro cellular analysis and in vivo evaluation demonstrated effective tumor therapeutic potency for current nanoparticles.
We report on diselenide-rich amphiphilic triblock copolymers with optimized components to fabricate combined drug delivery systems. Traceless core crosslinking was performed upon visible light irradiation for these nanoparticles, which significantly improve their physiological stability and avoid side effects due to minimal premature drug leakage during blood circulation. Whereas, efficient combined drug release were observed in tumors' redox microenvironments. In vitro cellular analysis and in vivo evaluation demonstrated effective tumor therapeutic potency for current nanoparticles.
引文
[1]Hu,X.L.;Liu,G.;Wang,X.;Liu,S.Y.J.Am.Chem.Soc.2015,137:362.
[2]Hu,X.L.;Hu,J.;Tian,J.;Ge,Z.,Zhang,G.;Luo,K.;Liu,S.Y.J.Am.Chem.Soc.2013,135:17617.
[3]Ji,S.;Cao,W.;Yu,Y.;Xu,H.Angew Chem.Int.Ed.2014,53:6781.
[4]Ji,S.;Cao,W.;Yu,Y.;Xu,H.Adv.Mater.2015,27:7740.
[2]Hu,X.L.;Hu,J.;Tian,J.;Ge,Z.,Zhang,G.;Luo,K.;Liu,S.Y.J.Am.Chem.Soc.2013,135:17617.
[3]Ji,S.;Cao,W.;Yu,Y.;Xu,H.Angew Chem.Int.Ed.2014,53:6781.
[4]Ji,S.;Cao,W.;Yu,Y.;Xu,H.Adv.Mater.2015,27:7740.