便携式静电纺丝装置原位喷敷纳米纤维抗菌敷料
详细信息 查看官网全文
- 英文论文题名：In-situ Deposition of Personalized Nanofibrous Dressing via A Handy Electrospinning Device for Skin Wound Care
- 论文作者：董瑞华 ; 龙云泽
- 英文论文作者：Rui-Hua Dong ; Yun-Ze Long ; Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices ; College of Physics ; Qingdao University
- 年：2016
- 作者机构：青岛大学物理科学学院;
- 论文关键词：原位电纺 ; 医用敷料 ; 伤口愈合
- 会议召开时间：2016-11-18
- 会议录名称：中国第四届静电纺丝大会（CICE 2016）摘要集
- 语种：中文
- 分类号：TQ340.64
- 学会代码：ZGNM
- 会议名称：中国第四届静电纺丝大会(CICE 2016)
- 会议地点：中国北京
- 主办单位：中国复合材料学会超细纤维材料分会（筹）
- 学会名称：中关村科创纳米技术创新研究会
- 页数：1
- 文件大小：615k
- 原文格式：D
- 会议级别：全国
摘要
静电纺聚合物纳米纤维具有巨大的比表面积和高孔隙率,是制备创伤敷料的理想材料。本文利用一种便携式手持静电纺丝装置在伤口表面直接喷敷Ag-MSNs/PCL纳米纤维抗菌敷料,并对其性能和治疗效果进行了系统研究。在体外实验中,利用扫描电镜、红外衍射光谱、热重分析和接触角对纳米纤维敷料的形貌、组分、热稳定性和亲/疏水性进行了分析。抑菌环和动物实验结果表明直接喷敷的纳米纤维敷料具有良好的光谱抗菌效果,可以有效防止创面感染,促进伤口愈合。
The goal of this work is to develop an in-situ deposition of personalized nanofibrous dressing via a handy electrospinning(e-spinning) device and evaluate its properties related to skin wound care. MCM-41 type mesoporous silica nanoparticles decorated with silver nanoparticles(Ag-MSNs) were prepared by a facile and environmentally friendly approach, which possessed long-term antibacterial activity and low cytotoxicity. Poly-ε-caprolactone(PCL) incorporated of Ag-MSNs was successfully electrospun(e-spun) into nanofibrous membranes. These in-situ e-spun nanofibrous membranes allowed continuous release of Ag ions and showed broad-spectrum antimicrobial activity against two common types of pathogens, Staphylococcus aureus and Escherichia coli. In addition, the in vivo studies revealed that these antibacterial nanofibrous membranes could reduce the inflammatory response and accelerate wound healing in Wistar rats. The above results strongly demonstrate that such patient-specific dressings could be broadly applied in emergency medical transport, hospitals, clinics and at the patients' home in the near future.
The goal of this work is to develop an in-situ deposition of personalized nanofibrous dressing via a handy electrospinning(e-spinning) device and evaluate its properties related to skin wound care. MCM-41 type mesoporous silica nanoparticles decorated with silver nanoparticles(Ag-MSNs) were prepared by a facile and environmentally friendly approach, which possessed long-term antibacterial activity and low cytotoxicity. Poly-ε-caprolactone(PCL) incorporated of Ag-MSNs was successfully electrospun(e-spun) into nanofibrous membranes. These in-situ e-spun nanofibrous membranes allowed continuous release of Ag ions and showed broad-spectrum antimicrobial activity against two common types of pathogens, Staphylococcus aureus and Escherichia coli. In addition, the in vivo studies revealed that these antibacterial nanofibrous membranes could reduce the inflammatory response and accelerate wound healing in Wistar rats. The above results strongly demonstrate that such patient-specific dressings could be broadly applied in emergency medical transport, hospitals, clinics and at the patients' home in the near future.
引文
[1]Zahedi,P;Rezaeian,I;Ranaei,S O;et al.Polym.Adv Techn,2010,21,77.
[2]Tian,Y;Jiang,X.Y;et al.ACS Appl.Mater.Interfaces,2014,6,12038.
[3]Xu,S C;Long,Y.Z;et al.Nanoscale,2015,7,12351.
[2]Tian,Y;Jiang,X.Y;et al.ACS Appl.Mater.Interfaces,2014,6,12038.
[3]Xu,S C;Long,Y.Z;et al.Nanoscale,2015,7,12351.