体内自组装多肽纳米纤维可有效改善HIV疫苗的免疫质量
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- 英文论文题名：In situ formation of peptidic nanofibers can fundamentally optimize the quality of immune responses against HIV vaccine
- 论文作者：刘野 ; 邵一鸣 ; 蒋兴宇
- 英文论文作者：Ye Liu ; Yiming Shao ; Xingyu Jiang ; CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety ; National Center for Nano Science and Technology ; State Key Laboratory of Infectious Disease Prevention and Control ; National Center for AIDS/STD Control and Prevention ; Chinese Center for Disease Control and Prevention
- 年：2016
- 作者机构：国家纳米科学中心;中国疾病预防控制中心性病艾滋病中心;
- 论文关键词：多肽纳米纤维 ; 体内自组装 ; HIV疫苗 ; 免疫反应类型
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：R392-33
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：158k
- 原文格式：D
- 会议级别：全国
摘要
本研究中,我们报道了一类可依赖于体内磷酸酶的催化,而自组装形成纳米纤维的多肽材料。该类材料可有效改善多种类型的、HIV DNA疫苗引发的免疫反应。这些免疫反应的类型包括:多功能性T细胞反应、广谱的IgG亚型反应、V1/V2区的特异性抗体反应。这些反应对于HIV的体内抑制发挥着重要作用,并且这些免疫反应类型尚不能被单独的HIV DNA疫苗所诱导。由于我们的多肽材料可借助于体内的磷酸酶而自组装形成纳米纤维,他因此避免了需要在体内加入磷酸酶而促使其形成纳米纤维的过程,本质上克服了疫苗实际应用中的巨大障碍。总体而言,这类自组装的多肽纳米材料,将有效提升HIV疫苗应用中的关键免疫反应类型,更好的预防和抑制HIV的感染和发展。
Herein, we report that the in situ formed peptidic nanofibers facilitate the induction of multiple crucial immunities against HIV DNA vaccine, including polyfunctional T cell response, broad Ig G subclasses response, and V1/V2 loop-specific antibody response, all of which can hardly be triggered by HIV DNA vaccine alone. Such novel in situ formation fundamentally overcomes the big hurdle for the applications of such nanofibers, which previously can only trigger these crucial immune responses via adding exogenous alkaline phosphatase. Such robustness of peptidic nanofibers for inducing crucial immune responses may allow better inhibition against HIV than reported materials.
Herein, we report that the in situ formed peptidic nanofibers facilitate the induction of multiple crucial immunities against HIV DNA vaccine, including polyfunctional T cell response, broad Ig G subclasses response, and V1/V2 loop-specific antibody response, all of which can hardly be triggered by HIV DNA vaccine alone. Such novel in situ formation fundamentally overcomes the big hurdle for the applications of such nanofibers, which previously can only trigger these crucial immune responses via adding exogenous alkaline phosphatase. Such robustness of peptidic nanofibers for inducing crucial immune responses may allow better inhibition against HIV than reported materials.
引文
[1]Tian,Y.;Wang,H.;Liu,Y.;Mao,L.;Chen,W.;Zhu,Z.;Liu,W.;Zheng,W.;Zhao,Y.;Kong,D.;Yang,Z.;Zhang,W.;Shao,Y.;Jiang,X.Nano.Lett.,2014,14:1439.
[2]Barouch,D.H.;Deeks,S.G.Science,2014,345:169.
[2]Barouch,D.H.;Deeks,S.G.Science,2014,345:169.