基于硅酞菁的小分子靶向抗癌光敏剂的合成及性质
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- 英文论文题名：Synthesis and Properties of Small Molecular Targeting Anticancer Based on Silicon Phthalocyanine
- 论文作者：黄逸臻 ; 陈涓涓 ; 薛金萍
- 英文论文作者：Yizhen Huang ; Juanjuan Chen ; Jinping Xue ; State Key Laboratory of Photocatalysis on Energy and Environment ; College of Chemistry ; Fuzhou University
- 年：2016
- 作者机构：福州大学化学学院能源与环境光催化国家重点实验室;
- 论文关键词：光动力治疗 ; 酞菁硅 ; 分子靶向治疗 ; 光物理光化学性质
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十七分会：光化学
- 语种：中文
- 分类号：R914
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十七分会 ; 光化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：171k
- 原文格式：D
- 会议级别：全国
摘要
光敏剂是光动力治疗中的关键物质[1]。硅酞菁由于可在其轴向进行修饰,进而减弱了分子之间的聚集行为,成为酞菁类光敏剂的研究热点;同时近年来,光动力治疗与其它治疗方法联合应用取得了较好的效果[2]。本文将小分子靶向药物的活性结构域通过链接单元到具有轴向取代的酞菁硅的母环结构上,并测定其光物理和光化学参数。
Photosensitizer is key material of photodynamic therapy. Due to silicon phthalocyanine can be modified in its axial, and can significantly reduce the aggregation behavior of complexes. Also in recent years, photodynamic therapy in combination with other treatment methods have achieved good results. So in this paper, the small molecular targeted drugs of the active structure has link to silicon phthalocyanine which can replace of its axial groups. And determined it photophysical/photochemical parameters.
Photosensitizer is key material of photodynamic therapy. Due to silicon phthalocyanine can be modified in its axial, and can significantly reduce the aggregation behavior of complexes. Also in recent years, photodynamic therapy in combination with other treatment methods have achieved good results. So in this paper, the small molecular targeted drugs of the active structure has link to silicon phthalocyanine which can replace of its axial groups. And determined it photophysical/photochemical parameters.
引文
[1]Jia,X.;Yang,F-F.;Li,J.;Liu,J-Y.;et al.J.Med.Chem.2013,56:5797-5805.
[2]Zhang,F-L;Huang,Q.;Zheng,K.;et al.Chemical Communications,2013.49(83):9570-9572
[2]Zhang,F-L;Huang,Q.;Zheng,K.;et al.Chemical Communications,2013.49(83):9570-9572