终末期肾脏病患者血清hgf水平与动脉粥样硬化的关系
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- 论文作者：祝俊琪 ; 张志辉 ; 祝素平 ; 单国浩 ; 王春荣
- 年：2016
- 作者机构：河北省涿州市医院;
- 论文关键词：终末期 ; 肾脏病 ; 血清hgf ; 动脉粥样硬化
- 英文论文关键词：end-stage ; Kidney disease ; Serum levels of HGF ; Atherosclerosis
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R692;R543.5
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：1
- 文件大小：2017k
- 原文格式：D
- 会议级别：全国
摘要
目的:研究终末期肾脏病患者血清hgf水平与动脉粥样硬化的关系。方法:选取我院2013年7月至2015年7月在我院接受诊治的终末期肾脏病患者82例和健康对照组35例,测定血清HGF水平及其他生化指标,同时应用二维颈动脉超声检测IMT厚度及斑块形成。观察终末期肾脏病患者与对照组HGF及其他生化指标的关系,并对影响颈动脉IMT的多种因素进行多元逐步回归分析。结果:终末期肾脏病患者血清HGF水平较对照组明显升高[(902.33±231.87)pg/ml和(631.53±204.05)pg/ml,(P<0.05)],终末期肾脏病患者血清HGF水平越高,颈动脉粥样硬化病变程度越重。多元逐步回归分析显示,影响颈动脉IMT的因素有血清肝细胞生长因子、年龄、收缩压、CRP、高密度脂蛋白胆固醇及脂蛋白(a)等。结论:血清肝细胞生长因子水平升高可能是终末期肾脏病患者并发动脉粥样硬化的独立危险因素。
Objective: to study the patients with end-stage kidney disease(CKD) serum HGF level relationship with atherosclerosis. Selection Methods: from July 2013 to July 2015 in ourhospital for treatment, 82 cases of patients with end-stage renal disease and healthy control group 35 cases, the determination of serum HGF levels and other biochemical indicators, at the same time, application of two-dimensional carotid ultrasound detecting thickness of IMT and plaque formation. Observed in patients with end-stage kidney disease HGF and other biochemical indicators of relationswith the control, and the influence factors of carotid IMT are multiple stepwise regression analysis. Results: the serum HGF levels was significantly elevated in end-stage renal disease patients [pg/ml(902.33-231.87) and(631.53 + 204.05) pg/ml,(P < 0.05), end-stage renal disease patients serum HGF level is higher, the heavier the degree of carotid atherosclerotic lesions. Multiple stepwiseregression analysis showed that factors that affect the carotid IMT are serum levels of hepatocyte growth factor, age, systolic blood pressure, CRP, high-density lipoprotein cholesterol and lipoprotein(a). Conclusion: the serum levels of hepatocyte growth factor levels may be end-stage kidney disease patients complicated with independent risk factors for atherosclerosis.
Objective: to study the patients with end-stage kidney disease(CKD) serum HGF level relationship with atherosclerosis. Selection Methods: from July 2013 to July 2015 in ourhospital for treatment, 82 cases of patients with end-stage renal disease and healthy control group 35 cases, the determination of serum HGF levels and other biochemical indicators, at the same time, application of two-dimensional carotid ultrasound detecting thickness of IMT and plaque formation. Observed in patients with end-stage kidney disease HGF and other biochemical indicators of relationswith the control, and the influence factors of carotid IMT are multiple stepwise regression analysis. Results: the serum HGF levels was significantly elevated in end-stage renal disease patients [pg/ml(902.33-231.87) and(631.53 + 204.05) pg/ml,(P < 0.05), end-stage renal disease patients serum HGF level is higher, the heavier the degree of carotid atherosclerotic lesions. Multiple stepwiseregression analysis showed that factors that affect the carotid IMT are serum levels of hepatocyte growth factor, age, systolic blood pressure, CRP, high-density lipoprotein cholesterol and lipoprotein(a). Conclusion: the serum levels of hepatocyte growth factor levels may be end-stage kidney disease patients complicated with independent risk factors for atherosclerosis.
引文
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[1]李涛,魏鹍,李慧妍等.终末期肾衰维持血透患者动脉粥样硬化与血清HGF相关性探讨[C].//第十一届华北肾脏病研讨会暨北京2008年肾脏病年会、河北省肾脏病分会第四届第三次学术会议论文集.2008:294-295.
[2]李涛,魏鹍,李慧妍等.终末期肾衰维持血透患者动脉粥样硬化与血清HGF相关性探讨[J].山东医药,2008,48(14):73-74.
[3]慢性乙型肝炎血透析患者血清肝细胞生长因子水平与T淋巴细胞亚群的变化及二者与动脉粥样硬化的相关性[C].//中国工程院医药卫生学部肾脏病前沿论坛、第十三届华北地区暨北京市肾脏病学术年会论文集.2012:1-3.
[4]王海燕,杜建时,徐忠信等.缺血性脑血管病患者血清肝细胞生长因子含量变化及其临床意义[J].中国老年学杂志,2010,30(14):1949-1951.
[5]Watanatanbe T,Yarnamoto H,ldei T,eta1.Influence of imulinlike growth factor-1 and hepatocyte gromh factor OR carotid atheroselero-sis and congestive function in the elderly[J].Dement Geritlla-co[J].Disord,2004,18(1):67-74.
[1]李涛,魏鹍,李慧妍等.终末期肾衰维持血透患者动脉粥样硬化与血清HGF相关性探讨[C].//第十一届华北肾脏病研讨会暨北京2008年肾脏病年会、河北省肾脏病分会第四届第三次学术会议论文集.2008:294-295.
[2]李涛,魏鹍,李慧妍等.终末期肾衰维持血透患者动脉粥样硬化与血清HGF相关性探讨[J].山东医药,2008,48(14):73-74.
[3]慢性乙型肝炎血透析患者血清肝细胞生长因子水平与T淋巴细胞亚群的变化及二者与动脉粥样硬化的相关性[C].//中国工程院医药卫生学部肾脏病前沿论坛、第十三届华北地区暨北京市肾脏病学术年会论文集.2012:1-3.
[4]王海燕,杜建时,徐忠信等.缺血性脑血管病患者血清肝细胞生长因子含量变化及其临床意义[J].中国老年学杂志,2010,30(14):1949-1951.
[5]Watanatanbe T,Yarnamoto H,ldei T,eta1.Influence of imulinlike growth factor-1 and hepatocyte gromh factor OR carotid atheroselero-sis and congestive function in the elderly[J].Dement Geritlla-co[J].Disord,2004,18(1):67-74.