PLGA多功能纳米诊疗剂的制备及其在肿瘤可视化光热治疗中的应用
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- 英文论文题名：Synthesis of multifunctional PLGA nanotheranostics and its application in the tumor visible photothermal therapy
- 论文作者：笪榄月 ; 朱佳堃 ; 奚菊群
- 英文论文作者：Lanyue Da ; Jiakun Zhu ; Juqun Xi ; Department of Pharmacy ; School of Medicine ; Yangzhou University
- 年：2016
- 作者机构：扬州大学医学院药学系;
- 论文关键词：纳米诊疗剂 ; PLGA ; 核磁共振成像 ; 光热治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TQ421.7;TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：287k
- 原文格式：D
- 会议级别：全国
摘要
纳米诊疗剂是通过纳米合成技术制备出具备诊断和治疗双重特性的多功能纳米药物载体。本实验采用配位组装技术,制备多功能聚乳酸羟基乙酸(PLGA)纳米诊疗剂,并进行核磁成像引导下的肿瘤光热治疗。首先采用复乳法制备PLGA空白纳米粒,其次在其表面通过多巴胺的自聚反应修饰一层薄层(PDA),最后通过配位组装将Mn离子结合至PDA@PLGA的表面,构建Mn~(2+)-PDA@PLGA纳米诊疗剂。实验结果表明,在808nm红外光照射下,PDA良好的光热转换性能,可显著升高体系温度,到达光热治疗目的,同时,Mn离子作为临床分子影像造影剂对疾病进行诊断,实现肿瘤的可视化治疗。
Nanotheranostics is multifunctional nano drug carriers prepared by nano-synthesis technology with dual diagnosis and treatment characteristics. In this paper, the PLGA microcapsules were generated by the water-in-oil-in-water(W/O/W) double emulsion method, which are then modified with polydopamine(PDA) through the self-polymerization of dopamine. Finally, the Mn~(2+)-chelated PDA@PLGA nanoparticles were obtained as novel theranostic agents for simultaneous MRI signal enhancement and photothermal ablation of cancer cells. Therefore, the developed multifunctional PLGA nanoparticles could be used as a promising theranostic agent for MRI-guided photothermal therapy of cancer cells.
Nanotheranostics is multifunctional nano drug carriers prepared by nano-synthesis technology with dual diagnosis and treatment characteristics. In this paper, the PLGA microcapsules were generated by the water-in-oil-in-water(W/O/W) double emulsion method, which are then modified with polydopamine(PDA) through the self-polymerization of dopamine. Finally, the Mn~(2+)-chelated PDA@PLGA nanoparticles were obtained as novel theranostic agents for simultaneous MRI signal enhancement and photothermal ablation of cancer cells. Therefore, the developed multifunctional PLGA nanoparticles could be used as a promising theranostic agent for MRI-guided photothermal therapy of cancer cells.
引文
[1]Joonyoung Park,Tarsis F.Brust,Hong Jae Lee,Sang Cheon Lee,Val J.Watts,and Yoon Yeo,ACS Nano,2014,8(4):3347-3356.
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