疏肝解郁胶囊联合西药治疗肝郁脾虚抑郁症的疗效观察
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- 英文论文题名：Liver spleen Depression Efficacy liver qi stagnation combined with western medicine capsules
- 论文作者：张景明
- 年：2014
- 作者机构：舟山市第二人民医院;
- 论文关键词：疏肝解郁胶囊 ; 肝郁脾虚 ; 抑郁症 ; 西药 ; 疗效
- 英文论文关键词：liver qi stagnation capsules ; liver spleen ; depression ; medicine ; efficacy
- 会议召开时间：2014-11-20
- 会议录名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会论文汇编
- 语种：中文
- 分类号：R749.4
- 学会代码：ZJKX
- 会议名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会
- 会议地点：中国浙江湖州
- 主办单位：浙江省医学会精神病学分会（The Society of Psychiatry ; ZJMA）、浙江省医师协会精神科医师分会
- 学会名称：浙江省科学技术协会
- 页数：3
- 文件大小：239k
- 原文格式：O
- 会议级别：地方
摘要
目的:探讨肝郁脾虚型抑郁症患者应用疏肝解郁胶囊联合西药治疗临床疗效及其安全性进行评价,为临床诊断治疗提供一定的科学依据。方法:将本组纳入的132例肝郁脾虚型抑郁症患者根据随机数字表法随机分为对照组和观察组,每组各66例。对照组给予西药进行治疗,观察组在对照组治疗基础上结合疏肝解郁胶囊进行治疗;对比分析两组患者治疗后临床疗效、HAMD评分以及不良反应。结果:观察组治疗2个疗程后总有效率(89.39%)显著高于对照组(73.64%),且差异具有统计学意义(P<0.05);观察组治疗后HAMD评分(8.47±3.12)分显著低于对照组治疗后(13.18±2.39)分,且差异具有统计学意义(P<0.05);两组患者均未发生明显的不良反应。结论:肝郁脾虚型抑郁症患者应用疏肝解郁胶囊联合西药治疗临床疗效显著,不良反应少,临床上应用安全可靠,值得临床进一步推广应用。
Objective:To investigate the liver and spleen deficiency in patients with liver stagnation and depression application capsule combined with western medicine clinical efficacy and safety evaluation,to provide a scientific basis for clinical diagnosis and treatment.Methods:This group included 132 cases of liver and spleen deficiency in patients with depression were randomly divided into control group and observation group based on a random number table,66 cases in each group.Control group was given medicine for treatment,observation group combined liver qi stagnation capsules for treatment on the basis of the control group;comparative analysis of two groups of patients after clinical efficacy,HAMD score,and adverse reactions.Results:The total effective rate(89.39%) was significantly higher(73.64%) after 2 courses of treatment,and the difference was statistically significant(P<0.05);HAMD score after the observation group(8.47 ± 3.12) points significantly lower than in the control group(13.18 ± 2.39) points,and the difference was statistically significant(P<0.05);groups were no significant adverse reactions occur.Conclusion:Patients with depression liver qi stagnation liver spleen applications combined with western medicine capsule significant clinical efficacy,adverse reactions,the clinical application of safe,reliable,worthy of further clinical application.
Objective:To investigate the liver and spleen deficiency in patients with liver stagnation and depression application capsule combined with western medicine clinical efficacy and safety evaluation,to provide a scientific basis for clinical diagnosis and treatment.Methods:This group included 132 cases of liver and spleen deficiency in patients with depression were randomly divided into control group and observation group based on a random number table,66 cases in each group.Control group was given medicine for treatment,observation group combined liver qi stagnation capsules for treatment on the basis of the control group;comparative analysis of two groups of patients after clinical efficacy,HAMD score,and adverse reactions.Results:The total effective rate(89.39%) was significantly higher(73.64%) after 2 courses of treatment,and the difference was statistically significant(P<0.05);HAMD score after the observation group(8.47 ± 3.12) points significantly lower than in the control group(13.18 ± 2.39) points,and the difference was statistically significant(P<0.05);groups were no significant adverse reactions occur.Conclusion:Patients with depression liver qi stagnation liver spleen applications combined with western medicine capsule significant clinical efficacy,adverse reactions,the clinical application of safe,reliable,worthy of further clinical application.
引文
[1]Grote N K,Bridge J A,Gavin A R,et al.A meta-analysis of depression during pregnancy and the risk of preterm birth,low birth weight,and intrauterine growth restriction[J].Archives of general psychiatry,2010,67(10):1012-1024.
[2]虢周科,吕琪,张春雷,等.郁乐方治疗心肝郁热型抑郁症疗效观察及其对血浆5-HTNE水平的影响[J].中华中医药学刊,2009,27(8):1720-1726.
[3]Karg K,Burmeister M,Shedden K,et al.The serotonin transporter promoter variant(5-HTTLPR),stress,and depression metaanalysis revisited:evidence of genetic moderation[TJ.Archives of general psychiatry,2011,68(5):444-454.
[4]颜景祥,王健,杜波,等.艾司西酞普兰与西酞普兰治疗抑郁症的对照研究[J].中国临床药理学杂志,2012,28(5):340-342.
[5]蔡兴黎,彭春悦,黄志华.中西医结合治疗抑郁症50例[J].中国中医药现代远程教育,2013,7(1 o):35-36.
[6]谭涛,王金贵,孙庆.中西医结合治疗抑郁症疗效观察[J].山西中医,2012,28(9):16-17.
[7]高新立,马玲,闫翌君,等.中西医结合治疗抑郁症60例[J].河南中医,2013,33(6):943-944.
[8]叶英响,何益新.不同剂量舒肝解郁胶囊治疗中度抑郁症66例[J].中医杂志,2012,53(12):1056-1058.
[9]Raison C L,Rutherford R E,Woolwine B J,et al.A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression:the role of baseline inflammatory biomarkers[J].JAMA psychiatry,2013,70(1):31-41.
[10]罗强,谢洪武,徐放明,等.针刺放血法结合氟西汀治疗抑郁症的临床疗效及其对血清细胞因子的影响[J].中国老年学杂志,2013,33(3):526-528.
[11]孔庆梅,舒良,张鸿燕,等.巴戟天寡糖胶囊治疗抑郁症的临床疗效与安全性[J].中国临床药理学杂志,2011,27(3):170-173.
[12]邵妍,陈以国,王鹏琴,等.针刺结合中药治疗抑郁症的临床疗效分析及评价体系[J].中国中医基础医学杂志,2013,6(3):331-333.
[13]包祖晓,赵国平,孙伟,等.开心散治疗轻,中度抑郁症临床观察[J]_中华中医药学刊,2011,29(5):987-988.
[14]李润霞,张峥,刘艳清.舒肝解郁胶囊联合西酞普兰治疗脑卒中后抑郁[J].长春中医药大学学报,2014,30(1):101-102.
[15]茅卫兵,朱宏志.舒肝解郁胶囊治疗老年抑郁症的临床观察[J].临床合理用药杂志,2010,3(21):45-46.
[2]虢周科,吕琪,张春雷,等.郁乐方治疗心肝郁热型抑郁症疗效观察及其对血浆5-HTNE水平的影响[J].中华中医药学刊,2009,27(8):1720-1726.
[3]Karg K,Burmeister M,Shedden K,et al.The serotonin transporter promoter variant(5-HTTLPR),stress,and depression metaanalysis revisited:evidence of genetic moderation[TJ.Archives of general psychiatry,2011,68(5):444-454.
[4]颜景祥,王健,杜波,等.艾司西酞普兰与西酞普兰治疗抑郁症的对照研究[J].中国临床药理学杂志,2012,28(5):340-342.
[5]蔡兴黎,彭春悦,黄志华.中西医结合治疗抑郁症50例[J].中国中医药现代远程教育,2013,7(1 o):35-36.
[6]谭涛,王金贵,孙庆.中西医结合治疗抑郁症疗效观察[J].山西中医,2012,28(9):16-17.
[7]高新立,马玲,闫翌君,等.中西医结合治疗抑郁症60例[J].河南中医,2013,33(6):943-944.
[8]叶英响,何益新.不同剂量舒肝解郁胶囊治疗中度抑郁症66例[J].中医杂志,2012,53(12):1056-1058.
[9]Raison C L,Rutherford R E,Woolwine B J,et al.A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression:the role of baseline inflammatory biomarkers[J].JAMA psychiatry,2013,70(1):31-41.
[10]罗强,谢洪武,徐放明,等.针刺放血法结合氟西汀治疗抑郁症的临床疗效及其对血清细胞因子的影响[J].中国老年学杂志,2013,33(3):526-528.
[11]孔庆梅,舒良,张鸿燕,等.巴戟天寡糖胶囊治疗抑郁症的临床疗效与安全性[J].中国临床药理学杂志,2011,27(3):170-173.
[12]邵妍,陈以国,王鹏琴,等.针刺结合中药治疗抑郁症的临床疗效分析及评价体系[J].中国中医基础医学杂志,2013,6(3):331-333.
[13]包祖晓,赵国平,孙伟,等.开心散治疗轻,中度抑郁症临床观察[J]_中华中医药学刊,2011,29(5):987-988.
[14]李润霞,张峥,刘艳清.舒肝解郁胶囊联合西酞普兰治疗脑卒中后抑郁[J].长春中医药大学学报,2014,30(1):101-102.
[15]茅卫兵,朱宏志.舒肝解郁胶囊治疗老年抑郁症的临床观察[J].临床合理用药杂志,2010,3(21):45-46.