孕早期甲状腺过氧化物酶抗体阳性对妊娠结局的影响
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- 论文作者：张平
- 年：2016
- 作者机构：邯郸市中心医院东区产科;
- 论文关键词：甲状腺过氧化物酶抗体 ; 促甲状腺激素 ; 不良妊娠结局
- 英文论文关键词：Gestation period ; Thyroid peroxidase antibody(TPOAb) ; Adverse pregnancy
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R714
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：1897k
- 原文格式：D
- 会议级别：全国
摘要
目的通过对孕早期甲状腺过氧化物酶抗体的测定,了解其对妊娠结局的影响。方法选取2015年6月至2016年3月在邯郸市中心医院产检的健康孕妇406例,于孕早期测定甲状腺过氧化物酶抗体(Thyroid peroxidase antibody,TPOAb)及促甲状腺激素(TSH)水平,按照TPOAb阳性和阴性分为两组,比较两组孕妇甲状腺功能异常及不良妊娠结局发生情况。结果 TPOAb阳性组甲状腺功能异常率为13.3%,明显高于TPOAb阴性组甲状腺功能异常率为5.0%,两组比较差异有统计学意义(P<0.05)。TPOAb阳性组不良妊娠结局发生率为30.5%,明显高于TPOAb阴性组甲状腺功能异常率为19.8%,两组比较差异有统计学意义(P<0.05)。结论 TPOAb阳性孕妇甲状腺功能异常发生率明显升高,提示TPOAb可作为孕早期筛查甲状腺功能的参考指标。TPOAb阳性孕妇产科合并症明显增多,表明阳性对其妊娠结局有不利影响。
Objective To explore the relationship between pregnancy with positive thyroid peroxidase antibody(TPOAb) in late pregnancy and adverse pregnancy outcomes.MethodsFrom 2015 July to 2016 March in our hospital for prenatal examination of 406 cases of early pregnant women as the research object, which were divided into positive group and negative group withthyroid peroxidase antibody.Thyroid function were compared between the two groups of pregnant women in late pregnancy and abnomal rate,the incidence of adverse prengancy outcomes.ResultsThe abnormal rate of group maternal thyroid function test was13.3%,singnificantly higher than the negative group 5.0%,the difference was statistically significant P < 0.05.the positive group ofpregnant women with adverse pregancy rate was30.5%,significantly higher than the negative group 19.8%,the difference was statistically significant P < 0.05.Conclusion During gestation period,the TPOAb was significant for the screening of the thyroidism,as well for adverse pregnancy.
Objective To explore the relationship between pregnancy with positive thyroid peroxidase antibody(TPOAb) in late pregnancy and adverse pregnancy outcomes.MethodsFrom 2015 July to 2016 March in our hospital for prenatal examination of 406 cases of early pregnant women as the research object, which were divided into positive group and negative group withthyroid peroxidase antibody.Thyroid function were compared between the two groups of pregnant women in late pregnancy and abnomal rate,the incidence of adverse prengancy outcomes.ResultsThe abnormal rate of group maternal thyroid function test was13.3%,singnificantly higher than the negative group 5.0%,the difference was statistically significant P < 0.05.the positive group ofpregnant women with adverse pregancy rate was30.5%,significantly higher than the negative group 19.8%,the difference was statistically significant P < 0.05.Conclusion During gestation period,the TPOAb was significant for the screening of the thyroidism,as well for adverse pregnancy.
引文
[1]Lin L,Zhang XL,Long Y.Analysis of thyroid peroxidase antibody in early pregnancy.Gente Mol Res,2014,13(3):5107-5114
[2]Lepoutre T,Debieve F,Gruson D,et al.Reduction of miscarriages autoimmunediseases.Gynecol Obster Invest,2012,74(4):265-273
[3]江琳琳,黄佳,杨冬梓.抗甲状腺抗体与妊娠相关疾病关系的研究进展.中华妇产科杂志,2013,48(3):222-224
[4]董丽,孙丽芳,甲状腺自身抗体和促甲状腺素预测流产的价值.中国妇产科临床杂志,2011,12(3):191-193
[5]滕卫平,段涛,宁光,等,妊娠和产后甲状腺疾病诊治指南.中华内分泌代谢杂志,2012,28(5):354-371
[6]中华医学会内分泌学会,中华医学会围产医学分会,妊娠和产后甲状腺疾病诊治指南.中华围产医学杂志,2012,15(17):385-403
[7]Behrooz HG,Tohidi M,Mehrabi Y,et al.Subclinical hypothyroidism in pregnancy:intellectual development of offspring.Thyroid,2011,21(10):1143-1147
[8]于晓会,范晨玲,滕卫平,等.妊娠期亚临床甲状腺功能减退症妇女甲状腺功能变化的随访研究.中国现代医学杂志,2013,23(1):61-65
[9]李连喜,罗敏.甲状腺自身抗体及其在AITD中的致病作用.国外医学内分泌学分册,2001,21(2):65-67
[10]陶征,吴洁,李连喜.自身免疫性甲状腺疾病甲状腺自身抗体的临床研究.江苏大学学报:医学版,2004,14(2):123-125
[11]曾智杰,姜傥,欧阳文婷.过氧化物酶抗体在妊娠甲状腺功能紊乱发生中的诊断价值.国际检验医学杂志,2006,27(3):199-202
[12]姚涛,刘萍,张清等,妊娠期甲状腺过氧化物酶抗体滴度与不良妊娠结局的关系.广东医学,2014,35(15):2400-2402
[13]单忠艳,妊娠期甲状腺功能减退症的药物治疗.药品评价,2012,9(13):19-23
[14]李春仙,妊娠早期甲状腺功能异常和自身抗体筛查的研究.中华内分泌代谢杂志,2013,29(2):152-153
[15]陆燕婷,赵晋华,汪太松,等.393例孕妇促甲状腺激素及甲状腺过氧化物酶抗体筛查结果分析.标记免疫分析与临床,2013,20(1):19-22
[16]董华,妊娠早期检测甲状腺过氧化物酶抗体的临床价值.医学信息,2010,5(5):1105-1106。
[17]GLINOER D,RIHI M,GRUN JP,et al.Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders.J Clin Endocrinol Metab,1994,79(1):197-204
[18]李春仙,妊娠早期甲状腺功能异常和自身抗体筛查的研究.中华内分泌代谢杂志,2013,29(2):152-153
[19]蒋优君,梁黎,朱红,等.孕母自身免疫性甲状腺疾病对婴儿甲状腺功能的多因素分析.中华内分泌代谢杂志,2004,20(14):307-310
[20]江琳琳,黄佳,杨冬梓.抗甲状腺抗体与妊娠相关疾病关系的研究进展.中华妇产科杂志,2013,48(3):222-224
[21]林清兰,林晓岚,麦尚敬.妊娠期糖尿病孕妇甲状腺功能及甲状腺自身抗体的变化.广东医药,2014,35(9):1355-1356
[2]Lepoutre T,Debieve F,Gruson D,et al.Reduction of miscarriages autoimmunediseases.Gynecol Obster Invest,2012,74(4):265-273
[3]江琳琳,黄佳,杨冬梓.抗甲状腺抗体与妊娠相关疾病关系的研究进展.中华妇产科杂志,2013,48(3):222-224
[4]董丽,孙丽芳,甲状腺自身抗体和促甲状腺素预测流产的价值.中国妇产科临床杂志,2011,12(3):191-193
[5]滕卫平,段涛,宁光,等,妊娠和产后甲状腺疾病诊治指南.中华内分泌代谢杂志,2012,28(5):354-371
[6]中华医学会内分泌学会,中华医学会围产医学分会,妊娠和产后甲状腺疾病诊治指南.中华围产医学杂志,2012,15(17):385-403
[7]Behrooz HG,Tohidi M,Mehrabi Y,et al.Subclinical hypothyroidism in pregnancy:intellectual development of offspring.Thyroid,2011,21(10):1143-1147
[8]于晓会,范晨玲,滕卫平,等.妊娠期亚临床甲状腺功能减退症妇女甲状腺功能变化的随访研究.中国现代医学杂志,2013,23(1):61-65
[9]李连喜,罗敏.甲状腺自身抗体及其在AITD中的致病作用.国外医学内分泌学分册,2001,21(2):65-67
[10]陶征,吴洁,李连喜.自身免疫性甲状腺疾病甲状腺自身抗体的临床研究.江苏大学学报:医学版,2004,14(2):123-125
[11]曾智杰,姜傥,欧阳文婷.过氧化物酶抗体在妊娠甲状腺功能紊乱发生中的诊断价值.国际检验医学杂志,2006,27(3):199-202
[12]姚涛,刘萍,张清等,妊娠期甲状腺过氧化物酶抗体滴度与不良妊娠结局的关系.广东医学,2014,35(15):2400-2402
[13]单忠艳,妊娠期甲状腺功能减退症的药物治疗.药品评价,2012,9(13):19-23
[14]李春仙,妊娠早期甲状腺功能异常和自身抗体筛查的研究.中华内分泌代谢杂志,2013,29(2):152-153
[15]陆燕婷,赵晋华,汪太松,等.393例孕妇促甲状腺激素及甲状腺过氧化物酶抗体筛查结果分析.标记免疫分析与临床,2013,20(1):19-22
[16]董华,妊娠早期检测甲状腺过氧化物酶抗体的临床价值.医学信息,2010,5(5):1105-1106。
[17]GLINOER D,RIHI M,GRUN JP,et al.Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders.J Clin Endocrinol Metab,1994,79(1):197-204
[18]李春仙,妊娠早期甲状腺功能异常和自身抗体筛查的研究.中华内分泌代谢杂志,2013,29(2):152-153
[19]蒋优君,梁黎,朱红,等.孕母自身免疫性甲状腺疾病对婴儿甲状腺功能的多因素分析.中华内分泌代谢杂志,2004,20(14):307-310
[20]江琳琳,黄佳,杨冬梓.抗甲状腺抗体与妊娠相关疾病关系的研究进展.中华妇产科杂志,2013,48(3):222-224
[21]林清兰,林晓岚,麦尚敬.妊娠期糖尿病孕妇甲状腺功能及甲状腺自身抗体的变化.广东医药,2014,35(9):1355-1356