近红外光可控释放一氧化氮纳米复合材料的设计、制备及其生物医学应用研究
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- 英文论文题名：Controllable Generation of Nitric Oxide by NIR-sensitized Nanoparticles in Biomedicine Applications
- 论文作者：张潇 ; 谷战军 ; 赵宇亮
- 英文论文作者：Xiao Zhang ; Zhanjun Gu ; Yuliang Zhao ; National Center for Nanoscience and Technology ; Chinese Academy of Sciences ; Institute of High Energy Physics ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院国家纳米科学中心;中国科学院高能物理研究所;
- 论文关键词：一氧化氮 ; 纳米复合材料 ; 近红外光 ; 肿瘤治疗 ; 协同治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;R318
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：227k
- 原文格式：D
- 会议级别：全国
摘要
一氧化氮是一种气态的脂溶性的生物活性分子,可以调控多种生理学过程。例如,抗血管再狭窄、伤口愈合、抗菌、抗肿瘤等。为克服现有的一氧化氮缓释分子的不足之处,我们设计制备了一种近红外光可控释放一氧化氮纳米复合材料。该纳米材料在近红外激光的驱动下,能够实现可控释放一氧化氮分子,具有反应灵敏、产率高、可控性好等特点。同时,由于近红外光在生物体内穿透深度高的特点,该材料非常适合运用于生物医学领域。我们将其用于肿瘤治疗中,发现一定浓度下的一氧化氮具备直接促使细胞凋亡坏死的作用。此外,一氧化氮与多种常规肿瘤治疗策略有协同效应,如增敏化疗、热疗和光动力治疗等,可间接地提高肿瘤治疗的疗效。该项工作为肿瘤治疗提供了新的思路,将有力推动一氧化氮介导的肿瘤治疗在生物医学领域的应用。
Nitric oxide(NO) is an endogenous gaseous biological mediator with pivotal roles in physiological and pathological processes and also is one of the structurally smallest pharmaceutical molecules bearing great potential as an anti-restenosis, wound healing, antibacterial and anticancer agent. In this work, we construct a novel NIR-triggered on-demand NO delivery platform. This nanocompound can absorb NIR photons, convert them and then transfer the energy to the NO donors making them release NO efficiently. By manipulating the output power of NIR light, the NO concentration-dependent biological effects for cancer therapy, where high concentration of NO could directly kill cancer cells and low concentration of NO could act as a potent P-glycoprotein(P-gp)modulator to overcome multi-drug resistance(MDR) once combined with chemotherapy, are achieved and investigated.
Nitric oxide(NO) is an endogenous gaseous biological mediator with pivotal roles in physiological and pathological processes and also is one of the structurally smallest pharmaceutical molecules bearing great potential as an anti-restenosis, wound healing, antibacterial and anticancer agent. In this work, we construct a novel NIR-triggered on-demand NO delivery platform. This nanocompound can absorb NIR photons, convert them and then transfer the energy to the NO donors making them release NO efficiently. By manipulating the output power of NIR light, the NO concentration-dependent biological effects for cancer therapy, where high concentration of NO could directly kill cancer cells and low concentration of NO could act as a potent P-glycoprotein(P-gp)modulator to overcome multi-drug resistance(MDR) once combined with chemotherapy, are achieved and investigated.
引文
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