一种基于长循环氧化铁纳米胶束的高性能T_2磁共振造影剂
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- 英文论文题名：A High-performance T_2 MRI Contrast Agent Based on Long-circulating Iron Oxide Nanomicelles
- 论文作者：张凯龙 ; 黄国明 ; 杨黄浩
- 英文论文作者：Kailong Zhang ; Guoming Huang ; Huang-Hao Yang ; The Key Lab of Analysis and Detection Technology for Food Safety of the MOE ; College of Chemistry ; Fuzhou University ; College of Biological Science and Engineering ; Fuzhou University
- 年：2016
- 作者机构：福州大学化学学院食品安全分析与检测技术教育部重点实验室;福州大学生物科学与工程学院;
- 论文关键词：PLGA-PEG ; 超顺磁性氧化铁 ; 长循环 ; T_2磁共振成像造影
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十八分会：化学生物学
- 语种：中文
- 分类号：R943;TB383.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十八分会 ; 化学生物学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：202k
- 原文格式：D
- 会议级别：全国
摘要
本文以两亲性聚合物PLGA-PEG和6nm超顺磁性氧化铁纳米粒子(SPIO)为原料,通过乳剂/溶剂挥发的方法,使PLGA-PEG自组装成胶束并将疏水性SPIO包裹起来,得到了50 nm的SPIO@PLGA-PEG纳米胶束。所合成的纳米胶束既拥有PLGA-PEG的生物相容性好、体内循环时间长等优点,同时由于SPIO的聚集体效应,因此其T_2磁共振造影性能也得到了极大提升。
In this study,we report the synthesis of novel nanomicelles using amphiphilic polymer PLGA-PEG and 6 nm superparamagnetic iron oxide nanoparticles(SPIO) as precursors.Through the emulsion/solvent evaporation method,PLGA-PEG can self-assemble into ~50 nm nanomicelles and the clustering of SPIO can be achieved in this process.The as-obtained SPIO@PLGA-PEG nanomicelles not only maintain the advantages of PLGA-PEG in good biocompatibility and long-circulating time,but also present a significant increase in T_2 MRI contrast enhancement due to the clustering effect of SPIO.
In this study,we report the synthesis of novel nanomicelles using amphiphilic polymer PLGA-PEG and 6 nm superparamagnetic iron oxide nanoparticles(SPIO) as precursors.Through the emulsion/solvent evaporation method,PLGA-PEG can self-assemble into ~50 nm nanomicelles and the clustering of SPIO can be achieved in this process.The as-obtained SPIO@PLGA-PEG nanomicelles not only maintain the advantages of PLGA-PEG in good biocompatibility and long-circulating time,but also present a significant increase in T_2 MRI contrast enhancement due to the clustering effect of SPIO.
引文
[1]Jianwei Guo,Xiaoling Gao,Lina Sua,Huimin Xia.Biomaterials.2011,32:8010.