利用聚合物多齿配体紧密包覆量子点的高效生物偶联
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- 英文论文题名：Multidentate Polymer Coatings for Compact and Homogeneous Quantum Dots with Efficient Bioconjugation
- 论文作者：屠春来 ; 马亮 ; Andrew M.Smith
- 英文论文作者：Chunlai Tu ; Liang Ma ; Andrew M. Smith ; School of Physical Science and Technology ; Shanghai Tech University ; Micro and Nanotechnology Laboratory ; University of Illinois at Urbana-Champaign
- 年：2016
- 作者机构：上海科技大学物质科学与技术学院;美国伊利诺伊大学厄巴纳-香槟分校;
- 论文关键词：聚合物多齿配体 ; 粒子表面改性 ; 单分散 ; 生物偶联 ; 生物成像
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：O641.4
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：278k
- 原文格式：D
- 会议级别：全国
摘要
通过合理设计的配位单体和亲水链单体的活性无规共聚合成的线性聚合物多齿配体,能够利用OH~-离子剥除量子点表面烷基链配体,再进行配体交换的方法,紧密包覆在具有核壳结构的CdSe/Cd_xZn_(1-x)S量子点表面,制备得到单分散的均相水溶液体系,并且能够减小量子点的水动力学尺寸,增强量子点的胶体稳定性和提高量子效率。表面功能改性的量子点能够进一步与生物大分子进行高效偶联,可用于生物靶向成像和单分子动态成像~([1])。
Linear polymeric multidentate ligands were rational designed and synthesized via living random copolymerization of coordinated and hydrophihc monomers.They can compactly coat on the surface of core/shell CdSe/Cd_xZn_(1-x)S QDs by ligand stripping-"displace nonpolar ligands with hydroxide ions" and then ligand exchanging method.It generates homogeneous and monodisperse aqueous solution which minimizing QD hydrodynamic size,enhancing colloidal stability and improving quantum yield.Furthermore,surface functionalized QDs can be efficiently bioconjugated with biological molecules.They are expected as exceptional probes for targeted imaging and single-molecule dynamic imaging.
Linear polymeric multidentate ligands were rational designed and synthesized via living random copolymerization of coordinated and hydrophihc monomers.They can compactly coat on the surface of core/shell CdSe/Cd_xZn_(1-x)S QDs by ligand stripping-"displace nonpolar ligands with hydroxide ions" and then ligand exchanging method.It generates homogeneous and monodisperse aqueous solution which minimizing QD hydrodynamic size,enhancing colloidal stability and improving quantum yield.Furthermore,surface functionalized QDs can be efficiently bioconjugated with biological molecules.They are expected as exceptional probes for targeted imaging and single-molecule dynamic imaging.
引文
[1]Ma L.;Tu C.;Le P.;Chitoor S.;Lim S.;Zahid M.;Teng K.;Ge P.;Selvin P.;Smith A.;J.Am.Chem.Soc.2016,138,3382-3394