微量高效精准药物分离分析新方法
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摘要
<正>药物分离分析是新药发现与创制中一项重要技术。药物代谢动力学、中药物质基础与活性成分分析以及组合生物合成与新药研发等均面临着体系复杂、实际样品分析中基质干扰、分离介质分子识别选择性差、分析目标物含量低微乃至低于先端仪器检测灵敏度等瓶颈问题,同时也给分析科学家提出了研究高效、微量、灵敏、精准分析新方法的机遇与挑战。近年来,本课题组致力于发展新型高效、微量、灵敏、精准药物分析方法学,开展了基于仿生
引文
1.J.Zhang,W.Zhang,T.Bao,Z.Chen*,Polydopamine-based immobilization of zeolitic imidazolate framework-8 for in-tube solid-phase microextraction,J.Chromatogr.A,2015,1388,9-16.
2 .Z.Zhang,W.Zhang,Z.Chen*,Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire,J.Chroamtogr.A,2015,1407:1-10.
3 .W.Zhang,Z.Zhang,J.Zhang,J.Meng,T.Bao,Z.Chen*,Covalent immobilization of graphene onto stainless steel wire for jacket-free stir bar sorptive extraction,J.Chromatogr.A,2014,1351:12-20.
4 .W.Zhang,J.Zhang,T.Bao,W.Zhou,J.Meng,Z.Chen*,Universal multilayer assemblies of graphene in chemically resistant micro-tubes for microextraction,Anal.Chem.2013,85:6845-6854.
5 .W.Zhang,Z.Chen*,Mussel inspired polydopamine functionalized poly(ether ether ketone)tube for online solid-phase microextraction-high performance liquid chromatography and its application in analysis of protoberberine alkaloids in rat plasma,J.Chromatogr.A,2013,1278:29-36.
6 .T.Bao,J.Zhang,W.Zhang,Z.Chen*,Growth of metal-organic framework HKUST-1 in capillary using liquid-phase epitaxy for open-tubular capillary electrochromatography and capillary liquid chromatography,J.Chromatogr.A,2015,1381:239-246.
7 .J.Zhang,W.Zhang,T.Bao,Z.Chen*,Enhancement of capillary electrochromatographic separation performance by conductive polymer in a layer-by-layer fabricated graphene stationary phase,J.Chromatogr.A,2014,1339:192-199.
8 .J.Zhang,W.Zhang,T.Bao,Z.Chen*,Mussel-inspired polydopamine-assisted hydroxyapatite as stationary phase for capillary electrochromatography,Analyst,2014,139:242-250.
9 .Y.Zhang,Z.Chen*,Nonaqueous Capillary Electrophoresis Electrospray Ionization-Ion Trap-Mass Spectrometric Analysis of Amaryllidaceae Alkaloids,J.Sep.Sci.2013,36:1078-1084.
10 .Q.Chen,J.Zhang,W.Zhang,Z.Chen*,Analysis of active alkaloids in family Menispermaceae by nonaqueous capillary electrophoresis-ion trap mass spectrometry,J.Sep.Sci.2013,36:341-349.
2 .Z.Zhang,W.Zhang,Z.Chen*,Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire,J.Chroamtogr.A,2015,1407:1-10.
3 .W.Zhang,Z.Zhang,J.Zhang,J.Meng,T.Bao,Z.Chen*,Covalent immobilization of graphene onto stainless steel wire for jacket-free stir bar sorptive extraction,J.Chromatogr.A,2014,1351:12-20.
4 .W.Zhang,J.Zhang,T.Bao,W.Zhou,J.Meng,Z.Chen*,Universal multilayer assemblies of graphene in chemically resistant micro-tubes for microextraction,Anal.Chem.2013,85:6845-6854.
5 .W.Zhang,Z.Chen*,Mussel inspired polydopamine functionalized poly(ether ether ketone)tube for online solid-phase microextraction-high performance liquid chromatography and its application in analysis of protoberberine alkaloids in rat plasma,J.Chromatogr.A,2013,1278:29-36.
6 .T.Bao,J.Zhang,W.Zhang,Z.Chen*,Growth of metal-organic framework HKUST-1 in capillary using liquid-phase epitaxy for open-tubular capillary electrochromatography and capillary liquid chromatography,J.Chromatogr.A,2015,1381:239-246.
7 .J.Zhang,W.Zhang,T.Bao,Z.Chen*,Enhancement of capillary electrochromatographic separation performance by conductive polymer in a layer-by-layer fabricated graphene stationary phase,J.Chromatogr.A,2014,1339:192-199.
8 .J.Zhang,W.Zhang,T.Bao,Z.Chen*,Mussel-inspired polydopamine-assisted hydroxyapatite as stationary phase for capillary electrochromatography,Analyst,2014,139:242-250.
9 .Y.Zhang,Z.Chen*,Nonaqueous Capillary Electrophoresis Electrospray Ionization-Ion Trap-Mass Spectrometric Analysis of Amaryllidaceae Alkaloids,J.Sep.Sci.2013,36:1078-1084.
10 .Q.Chen,J.Zhang,W.Zhang,Z.Chen*,Analysis of active alkaloids in family Menispermaceae by nonaqueous capillary electrophoresis-ion trap mass spectrometry,J.Sep.Sci.2013,36:341-349.