摘要
目的:探究脂肝合剂治疗非酒精性脂肪肝(NAFLD)的机理。方法:将造模成功并接受治疗后的Wistar大鼠取血样以及肝脏和小肠组织,检测血清LPS、血清血糖(FBG)、胰岛素(INS),肝脏TLR4、小肠Occludin蛋白等指标。结果:脂肝合剂组血清LPS、肝脏TLR4、肠道Occludin蛋白与模型组相比均有统计学差异,FBG、INS、胰岛素抵抗指标HOMA-IR与模型组相比无统计学差异。结论:LPS/TLR4通路是脂肝合剂治疗非酒精性脂肪肝的靶点之一。
引文
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