桑白皮、白术有效性味组分相互组合对阿霉素肾病大鼠的作用研究
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- 英文论文题名：Effects of the compatibility of effective chemical split fractions of Mori Cortex,Atractylodes macrocephala Koidz on adriamycin nephrosis rats
- 论文作者：吴广操 ; 牛艳 ; 李苗 ; 苏成福 ; 韩杜菀 ; 樊慧 ; 杨胜利 ; 王小兰 ; 冯卫生 ; 郑晓珂
- 年：2016
- 作者机构：河南中医药大学;呼吸疾病诊疗与新药研发河南省协同创新中心;
- 论文关键词：性味可组合性 ; 阿霉素肾病综合征
- 英文论文关键词：Components of the property and flavor ; Adriamycin nephrosis
- 会议召开时间：2016-09-27
- 会议录名称：中国药学会第十三届青年药学科研成果交流会论文集
- 语种：中文
- 分类号：R285.5
- 学会代码：YYWS
- 会议名称：中国药学会第十三届青年药学科研成果交流会
- 会议地点：中国江西南昌
- 主办单位：中国药学会
- 学会名称：中国药学会
- 页数：4
- 文件大小：210k
- 原文格式：O
- 会议级别：全国
摘要
目的:研究桑白皮、白术有效性味组分相互组合对阿霉素肾病大鼠的作用,为性味组分的可组合性研究提供理论依据。方法:采用阿霉素大鼠肾病模型,以大鼠24h尿蛋白、白蛋白(ALB)、甘油三酯(TG)、总胆固醇(TC)、肌酐(Cr)和尿素氮(BUN)的水平为评价指标,筛选出有效性味拆分组分相互组合的最佳组合。结果:与NC组相比,模型组大鼠24h尿蛋白、TC、TG、BUN、Cr含量显著性升高(P<0.01),ALB水平显著性降低(P<0.01);与M组相比,各给药组均能够降低阿霉素肾病大鼠的24h尿蛋白含量、血清TC、TG、BUN、Cr的含量(P<0.01或P<0.05),升高血清ALB含量(P<0.01)。结论MC-30:AmK-Pol组对阿霉素肾病的治疗作用最佳,初步表明其性味拆分组分具有可拆分、可组合的合理性。
Objective The aim of this study is to investigate compatibility of effective flavor split fractions of Mori Cortex,Rhizoma Atractylodis macrocephalae on Adriamycin(ADR)-induced nephropathy rats and providing theoretical basis for the research of the combination of the components of the property and flavor.Methods:Adriamycin nephrotic syndrome in rats model,24 h urine protein of rats,the levels of serum creatinine(Cr),urea nitrogen(BUN),triglycerides(TG),total cholesterol(TC) and albumin(ALB) to filtering out the best combination effect.Results:Compared with the normal group,the levels of Cr,TC,TG,BUN and 24 h in the model group were significantly increased(P<0.01),and the level of ALB was significantly lower(P<0.01).Each drug administration group could down-regulated the level of 24 h urinary protein,TC,TG,BUN and Cr obviously(P<0.01 or P<0.01),up-regulated the level of Alb obviously(P<0.01).Conclusions:The MC-30:AmK-Pol has the best Anti-nephrotic-syndrome effect,And flavor components can be combined.
Objective The aim of this study is to investigate compatibility of effective flavor split fractions of Mori Cortex,Rhizoma Atractylodis macrocephalae on Adriamycin(ADR)-induced nephropathy rats and providing theoretical basis for the research of the combination of the components of the property and flavor.Methods:Adriamycin nephrotic syndrome in rats model,24 h urine protein of rats,the levels of serum creatinine(Cr),urea nitrogen(BUN),triglycerides(TG),total cholesterol(TC) and albumin(ALB) to filtering out the best combination effect.Results:Compared with the normal group,the levels of Cr,TC,TG,BUN and 24 h in the model group were significantly increased(P<0.01),and the level of ALB was significantly lower(P<0.01).Each drug administration group could down-regulated the level of 24 h urinary protein,TC,TG,BUN and Cr obviously(P<0.01 or P<0.01),up-regulated the level of Alb obviously(P<0.01).Conclusions:The MC-30:AmK-Pol has the best Anti-nephrotic-syndrome effect,And flavor components can be combined.
引文
[1]匡海学,程伟.中药性味的可拆分性、可组合性研究—中药性味理论新假说与研究方法的探索[J].世界科学技术,2009,06:768-771
[2]王绅.中药桑白皮性昧拆分工艺研究.郑州:河南中医学院硕士学位论文,2014:32-68.
[3]周静,于洋,等.桑白皮各化学拆分组分对肾病综合征大鼠改善作用[A].中国药学会中药与天然药物专业委员会·2015:1.
[4]李玲辉,冉小库,等.白术组分拆分及组间差异度评价方法的建立[J].分析化学,2014,03:343-348.
[5]郑晓珂,于洋,等.白术各化学拆分组分及其配伍对大鼠肾病综合征的影响[J].中药新药与临床药理,2016,04:467-474.
[2]王绅.中药桑白皮性昧拆分工艺研究.郑州:河南中医学院硕士学位论文,2014:32-68.
[3]周静,于洋,等.桑白皮各化学拆分组分对肾病综合征大鼠改善作用[A].中国药学会中药与天然药物专业委员会·2015:1.
[4]李玲辉,冉小库,等.白术组分拆分及组间差异度评价方法的建立[J].分析化学,2014,03:343-348.
[5]郑晓珂,于洋,等.白术各化学拆分组分及其配伍对大鼠肾病综合征的影响[J].中药新药与临床药理,2016,04:467-474.