香蕉果胶对小鼠中铝介导认知损伤及蓄积效应的保护作用
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- 英文论文题名：Protective effects of banana pectin against aluminum-induced cognitive impairment and aluminum accumulation in mice
- 论文作者：曾祥权 ; 王晓梅 ; 赵韩栋 ; 奚宇 ; 曹建康 ; 姜微波
- 英文论文作者：Zeng Xiangquan ; Wang Xiaomei ; Zhao Handong ; Xi Yu ; Cao Jiankang ; Jiang Weibo ; College of Food Science and Nutritional Engineering ; China Agricultural University
- 年：2016
- 作者机构：中国农业大学食品科学与营养工程学院;
- 论文关键词：铝 ; 香蕉果胶 ; 铝吸收 ; 认知损伤 ; 铝蓄积
- 英文论文关键词：aluminum ; banana pectin ; aluminum absorption ; cognitive impairment ; aluminum accumulation
- 会议召开时间：2016-11-09
- 会议录名称：中国食品科学技术学会第十三届年会论文摘要集
- 英文会议录名称：Abstracts of the 13th Annual Meeting of CIFST
- 语种：中文
- 分类号：TS201.4
- 学会代码：ZGSP
- 会议名称：中国食品科学技术学会第十三届年会
- 会议地点：中国北京
- 主办单位：中国食品科学技术学会
- 学会名称：中国食品科学技术学会
- 页数：2
- 文件大小：117k
- 原文格式：O
- 会议级别：全国
摘要
为了解果胶对食源铝吸收及其生物毒性的影响,本研究用香蕉果肉果胶粗提物给铝暴小鼠(35mg Al kg~(-1)d~(-1)(100mg kg~(-1)d~(-1)))灌胃处理6周。结果表明,果胶灌胃处理能使铝暴小鼠的平均体重提高32.5%。在跳台试验和水迷宫实验中,果胶灌胃处理使铝暴露小鼠的空间记忆能力显著改善。代谢分析结果显示,香蕉果胶处理能够有效阻止小鼠对食源铝的吸收。灌胃第12天,香蕉果胶和铝复合处理组小鼠粪便和尿液排泄物中的铝含量比铝单独处理组小鼠粪便和尿液排泄物中的铝含量要高9.3%。灌胃处理6周后,香蕉果胶和铝复合处理组小鼠血清、小脑和大脑中的铝水平分别比单独铝暴露小鼠血清、小脑和大脑中的铝水平低30.8%、17.5%和17.9%。本研究结果证明,果胶提取物能够减弱铝对小鼠认知损伤及体内的铝蓄积,从而具有抑制铝生物毒性的作用。
To investigate the effect of pectin on absorption and bio-toxicity of aluminum,pectin extract(100mg kg~(-1)d~(-1))from banana pulp was orally administrated to aluminum exposed mice(35 mg kg ~(-1) d~(-1)) for 6 weeks.Our result showed that body weight gain of the mice treated with aluminum plus banana pectin was 32.5%higher than that of mice exposed to aluminum alone after 6 weeks of the administration.In both the Step-down inhibitory avoidance task and Morris water maze test,memory retention of aluminum-exposed mice was significandy improved by the pectin administration.In metabolic test,treatment with banana pectin effectively prevented absorption of aluminum from the gastrointestinal tract,total aluminum excretion of mice treated with banana pectin plus aluminum was 9.3%higher than that of mice exposed to aluminum alone on the 12~(th)day.Aluminum level in serum,cerebrum or cerebellum of mice treated with aluminum plus banana pectin was 30.8%,17.5%or 17.9%lower than that of that of mice exposed to aluminum alone at end of the administration,respectively.In conclusion,banana pectin extract can effectively reduce the bio-toxicity of aluminum in mice via protecting them from aluminum-induced cognitive impairment and aluminum accumulation in vivo.
To investigate the effect of pectin on absorption and bio-toxicity of aluminum,pectin extract(100mg kg~(-1)d~(-1))from banana pulp was orally administrated to aluminum exposed mice(35 mg kg ~(-1) d~(-1)) for 6 weeks.Our result showed that body weight gain of the mice treated with aluminum plus banana pectin was 32.5%higher than that of mice exposed to aluminum alone after 6 weeks of the administration.In both the Step-down inhibitory avoidance task and Morris water maze test,memory retention of aluminum-exposed mice was significandy improved by the pectin administration.In metabolic test,treatment with banana pectin effectively prevented absorption of aluminum from the gastrointestinal tract,total aluminum excretion of mice treated with banana pectin plus aluminum was 9.3%higher than that of mice exposed to aluminum alone on the 12~(th)day.Aluminum level in serum,cerebrum or cerebellum of mice treated with aluminum plus banana pectin was 30.8%,17.5%or 17.9%lower than that of that of mice exposed to aluminum alone at end of the administration,respectively.In conclusion,banana pectin extract can effectively reduce the bio-toxicity of aluminum in mice via protecting them from aluminum-induced cognitive impairment and aluminum accumulation in vivo.
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