氟西汀合并齐拉西酮治疗首发脑卒中后抑郁症的临床疗效及安全性研究
详细信息 查看官网全文
- 英文论文题名：Clinical study of fluoxetine plus ziprasidone in the treatment of inpatients with posts-troke depression
- 论文作者：廖峥娈 ; 谭云飞 ; 仇雅菊 ; 朱俊鹏 ; 于恩彦
- 英文论文作者：LIAO Zheng-Luan ; TAN Yun-Fei ; QIU Ya-Ju ; ZHU Jun-Peng ; YU En-Yan
- 年：2014
- 作者机构：浙江省人民医院;
- 论文关键词：氟西汀 ; 齐拉西酮 ; 脑卒中 ; 抑郁症
- 英文论文关键词：Fluoxetine ; Ziprasidone ; Poststroke ; Depression
- 会议召开时间：2014-11-20
- 会议录名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会论文汇编
- 语种：中文
- 分类号：R743.3;R749.4
- 学会代码：ZJKX
- 会议名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会
- 会议地点：中国浙江湖州
- 主办单位：浙江省医学会精神病学分会（The Society of Psychiatry ; ZJMA）、浙江省医师协会精神科医师分会
- 学会名称：浙江省科学技术协会
- 页数：3
- 文件大小：229k
- 原文格式：O
- 会议级别：地方
摘要
目的:观察氟西汀联合小剂量齐拉西酮治疗首发脑卒中后抑郁症的疗效和副反应情况。方法:90例首发脑卒中后抑郁症患者被随机分为氟西汀组和治疗组(氟西汀联合小剂量齐拉西酮组),疗程6周。于治疗前和治疗第1、2、4、6周末分别采用汉密尔顿抑郁量表(HAMD)评定疗效和副反应量表(TESS)评定患者的副反应情况。结果:治疗6周末,氟西汀组的显效率为60%,而治疗组的显效率为80%,两者相比有统计学差异(P<0.05)。治疗第1、2、4周末,治疗组HAMD评分显著低于氟西汀组,两者相比有统计学差异(P<0.05),不良反应均较轻。结论:氟西汀合并小剂量齐拉西酮治疗脑卒中后抑郁比单纯应用氟西汀起效快,疗效好,不良反应轻,安全性高,依从性好。
Objective To investigate the clinical effect and side effects of fluoxetine plus low dose aripirazole in treating inpatients with first-episode poststroke depression.Methods Ninety inpatients with poststroke depression were randomly divided into control group(fluoxetine)and combined group(fluoxetine plus low-dose ziprasidone).The course of treatment was 6 weeks.The efficacy and side effects were assessed by HAMD and TESS before treatment and at the end of 1 st,2nd,4th and the 6th week after treatment.Results After 6 weeks,the improved rates were 80%in combined group and60%in control group,there was significant difference between two groups(P<0.05).At the end of 1 st,2nd and the 4th weeks,The scores of HAM D showed significant differences(P<0.05)The side effects in two groups were few.Conclusion Fluoxetine plus low dose ziprasidone has better effect and takes into effect earlier,and with lower incidences of adverse reactions,higher safety and better compliance for patients with poststroke depression.
Objective To investigate the clinical effect and side effects of fluoxetine plus low dose aripirazole in treating inpatients with first-episode poststroke depression.Methods Ninety inpatients with poststroke depression were randomly divided into control group(fluoxetine)and combined group(fluoxetine plus low-dose ziprasidone).The course of treatment was 6 weeks.The efficacy and side effects were assessed by HAMD and TESS before treatment and at the end of 1 st,2nd,4th and the 6th week after treatment.Results After 6 weeks,the improved rates were 80%in combined group and60%in control group,there was significant difference between two groups(P<0.05).At the end of 1 st,2nd and the 4th weeks,The scores of HAM D showed significant differences(P<0.05)The side effects in two groups were few.Conclusion Fluoxetine plus low dose ziprasidone has better effect and takes into effect earlier,and with lower incidences of adverse reactions,higher safety and better compliance for patients with poststroke depression.
引文