含糖三嵌段共聚物脱保护引发的形貌转变
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- 英文论文题名：Deprotection-induced morphology transformation of Triblock glycopolymer
- 论文作者：齐文静 ; 陈国颂
- 英文论文作者：Wenjing Qi ; Guosong Chen ; The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science ; Fudan University
- 年：2016
- 作者机构：聚合物分子工程国家重点实验室高分子科学系复旦大学;
- 论文关键词：含糖嵌段共聚物 ; 脱保护 ; 形貌转变
- 英文论文关键词：glycopolymers ; deprotection ; morphology transformation
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O631.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：212k
- 原文格式：D
- 会议级别：全国
摘要
糖类化合物是维持生命体新陈代谢的重要物质,多以糖蛋白、糖脂等糖缀合物的形式存在,因此含糖嵌段共聚物组装行为的研究有着广阔的生物学前景。在糖化学中,糖的保护与脱保护是糖合成中最为常见的方法,脱保护前后含糖嵌段亲疏水性发生巨大转变。基于此我们提出利用含糖嵌段的脱保护作为驱动力诱导含糖嵌段共聚物自组装的新路线。本工作利用可逆加成-断裂链转移聚合得到一系列结构规整的含糖三嵌段共聚物PEG-PGalAc-PS,在水中可以自组装形成囊泡。通过加入NaOH实现组装体在水溶液中的脱保护,大量羟基的暴露改变了三嵌段的亲疏水比,通过控制NaOH当量来调节脱保护的程度,从而得到组装体形貌从囊泡向胶束等一系列复杂的形貌转变。水相脱保护的进行为研究糖缀合物在生物体内的作用提供了基础。
Saccharides help the metabolism of organisms and play a crucial role in all kinds of vital processes. They always exist as glycoconjugates(glycoprotein and glycolipid). So researches related to self-assembly of glycopolymer draw focued attention. Protection and deprotection of hydroxyl groups in sugar molecule is widely used in chemical synthesis, which causes an obvious polarity change. A new strategy for self-assembly of sugar-containing block copolymers was proposed by our group based on the protection-deprotection chemistry. In this work, a series of well-defined triblock copolymers PEG-PGalA c-PS were obtained via RAFT polymerization, which self-assembled into vesicles in water. The acetyl groups were removed after NaO H was added into the aqueous solution, which resulted in morphology transformation-from vesicles to micelles, depending on the degree of deprotection. The possibility of deprotection in aqueous media promotes potential applications of this strategy in biological systems.
Saccharides help the metabolism of organisms and play a crucial role in all kinds of vital processes. They always exist as glycoconjugates(glycoprotein and glycolipid). So researches related to self-assembly of glycopolymer draw focued attention. Protection and deprotection of hydroxyl groups in sugar molecule is widely used in chemical synthesis, which causes an obvious polarity change. A new strategy for self-assembly of sugar-containing block copolymers was proposed by our group based on the protection-deprotection chemistry. In this work, a series of well-defined triblock copolymers PEG-PGalA c-PS were obtained via RAFT polymerization, which self-assembled into vesicles in water. The acetyl groups were removed after NaO H was added into the aqueous solution, which resulted in morphology transformation-from vesicles to micelles, depending on the degree of deprotection. The possibility of deprotection in aqueous media promotes potential applications of this strategy in biological systems.
引文
[1]Su,L.;Wang,C.;Polzer,F.;Lu,Y.;Chen,G.and Jiang,M.ACS Macro Lett.2014,3:534.
[2]Xiulong Wu,Lu Su,Guosong Chen*,and Ming Jiang.Macromolecules.2015,48:3705.
[2]Xiulong Wu,Lu Su,Guosong Chen*,and Ming Jiang.Macromolecules.2015,48:3705.