Dynamic Gene Expression Profiles during Postnatal Development of Porcine Subcutaneous Adipose
详细信息 查看官网全文
- 英文论文题名：Dynamic Gene Expression Profiles during Postnatal Development of Porcine Subcutaneous Adipose
- 论文作者：Zhang jie ; Ma jideng ; Long keren ; Jin long ; Liu yihui ; Zhou chaowei ; Tian shilin ; Chen lei ; Luo zonggang ; Tang qianzi ; Jiang an'an ; Wang xun ; Wang dawei ; Jiang zhi ; Wang jinyong ; Li xuewei ; Li mingzhou
- 英文论文作者：Zhang jie ; Ma jideng ; Long keren ; Jin long ; Liu yihui ; Zhou chaowei ; Tian shilin ; Chen lei ; Luo zonggang ; Tang qianzi ; Jiang an'an ; Wang xun ; Wang dawei ; Jiang zhi ; Wang jinyong ; Li xuewei ; Li mingzhou ; Institute of Animal Genetics and Breeding ; College of Animal Science and Technology ; Sichuan Agricultural University ; Department of Animal Science ; Southwest University at Rongchang ; Department of Aquaculture ; Southwest University at Rongchang ; Novogene Bioinformatics Institute ; Chongqing Academy of Animal Science
- 年：2016
- 作者机构：Institute of Animal Genetics and Breeding,College of Animal Science and Technology,Sichuan Agricultural University;Department of Animal Science,Southwest University at Rongchang;Department of Aquaculture,Southwest University at Rongchang;Novogene Bioinformatics Institute;Chongqing Academy of Animal Science;
- 会议召开时间：2016-05-25
- 会议录名称：第七届中国畜牧科技论坛论文集
- 英文会议录名称：Proceeding of the 7th China Animal Husbandry Sci-tech Forum
- 语种：英文
- 分类号：S828
- 学会代码：ZGXJ
- 会议名称：第七届中国畜牧科技论坛
- 会议地点：中国重庆
- 主办单位：中国畜牧兽医学会
- 学会名称：中国畜牧兽医学会
- 页数：2
- 文件大小：120k
- 原文格式：O
- 会议级别：全国
摘要
A better understanding of the control of lipogenesis is of critical importance for both human and animal physiology.This requires a better knowledge of the changes of gene expression during the process of adipose tissue development.Thus,the objective of the current study was to determine the effects of development on subcutaneous adipose tissue gene ex-pression in growing and adult pigs. Here, we present a comprehensive investigation of mRNA transcriptomes in porcine subcutaneous adipose tissue across four developmental stages using digital gene expression profiling. We identified 3 274 differential expressed genes associated with oxidative stress, immune processes, apoptosis, energy metabolism, insulin stimulus,cell cycle, angiogenesis and translation(P<0. 05). A set of universally abundant genes(ACOX3,iVD』,A/D2,SCD and 7T/BAJB) was found across all four developmental stages. This set of genes may play important roles in lipogenesis and development.We also identified development-related gene expression patterns that are linked to the different adipose phenotypes. We showed that genes enriched in significantly up-regulated profiles were associated with phosphorylation and angiogenesis. In contrast, genes enriched in significantly down-regulated profiles were related to cell cycle and cytoskeleton organization, suggesting an important role for these biological processes in adipose growth and development. These results provide a resource for studying adipose development and promote the pig as a model organism for researching the development of human obesity, as well as being used in the pig industry.
A better understanding of the control of lipogenesis is of critical importance for both human and animal physiology.This requires a better knowledge of the changes of gene expression during the process of adipose tissue development.Thus,the objective of the current study was to determine the effects of development on subcutaneous adipose tissue gene ex-pression in growing and adult pigs. Here, we present a comprehensive investigation of mRNA transcriptomes in porcine subcutaneous adipose tissue across four developmental stages using digital gene expression profiling. We identified 3 274 differential expressed genes associated with oxidative stress, immune processes, apoptosis, energy metabolism, insulin stimulus,cell cycle, angiogenesis and translation(P<0. 05). A set of universally abundant genes(ACOX3,iVD』,A/D2,SCD and 7T/BAJB) was found across all four developmental stages. This set of genes may play important roles in lipogenesis and development.We also identified development-related gene expression patterns that are linked to the different adipose phenotypes. We showed that genes enriched in significantly up-regulated profiles were associated with phosphorylation and angiogenesis. In contrast, genes enriched in significantly down-regulated profiles were related to cell cycle and cytoskeleton organization, suggesting an important role for these biological processes in adipose growth and development. These results provide a resource for studying adipose development and promote the pig as a model organism for researching the development of human obesity, as well as being used in the pig industry.
A better understanding of the control of lipogenesis is of critical importance for both human and animal physiology.This requires a better knowledge of the changes of gene expression during the process of adipose tissue development.Thus,the objective of the current study was to determine the effects of development on subcutaneous adipose tissue gene ex-pression in growing and adult pigs. Here, we present a comprehensive investigation of mRNA transcriptomes in porcine subcutaneous adipose tissue across four developmental stages using digital gene expression profiling. We identified 3 274 differential expressed genes associated with oxidative stress, immune processes, apoptosis, energy metabolism, insulin stimulus,cell cycle, angiogenesis and translation(P<0. 05). A set of universally abundant genes(ACOX3,iVD』,A/D2,SCD and 7T/BAJB) was found across all four developmental stages. This set of genes may play important roles in lipogenesis and development.We also identified development-related gene expression patterns that are linked to the different adipose phenotypes. We showed that genes enriched in significantly up-regulated profiles were associated with phosphorylation and angiogenesis. In contrast, genes enriched in significantly down-regulated profiles were related to cell cycle and cytoskeleton organization, suggesting an important role for these biological processes in adipose growth and development. These results provide a resource for studying adipose development and promote the pig as a model organism for researching the development of human obesity, as well as being used in the pig industry.
引文