鹿茸再生及分子调节研究进展
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- 英文论文题名：Antler regeneration and the research progress of molecular regulate
- 论文作者：刘振 ; 赵海平 ; 杨春 ; 褚文辉 ; 王大涛 ; 李春义
- 英文论文作者：Liu Zhen ; Zhao Haiping ; Yang Chun ; Chu Wenhui ; Wang Datao ; Li Chunyi ; State Key Laboratory of Special Economic Animal Molecular Biology ; Institute of Special Wild Economic Animals and Plants ; CAAS
- 年：2016
- 作者机构：吉林省特种经济动物分子生物学重点实验室中国农业科学院特产研究所;
- 论文关键词：鹿茸再生 ; 形态组织学 ; 信号通路 ; 生长调控
- 英文论文关键词：Antler regeneration ; Morphology and Histology ; Signal pathway ; Growth regulation
- 会议召开时间：2016-06-01
- 会议录名称：“十二五” 鹿科学研究进展
- 语种：中文
- 分类号：S825
- 学会代码：ZXMY
- 学会名称：中国畜牧业协会
- 页数：6
- 文件大小：305k
- 原文格式：O
摘要
鹿茸是唯一可以周期性完全再生的哺乳动物器官,这种再生起源于骨膜干细胞。鹿茸再生伴随着皮肤、血管和神经的快速生成,而且多种多肽和生长因子参与其中,组成了一系列复杂而精密的信号调控通路。本文综述了鹿茸再生过程的组织学及分子信号通路研究现状,以信号转导通路为研究重点揭示鹿茸再生之谜,期望更好地了解哺乳动物器官再生机制。
Deer antlers,derivatives of periosteum cells,are the only mammalian appendages capable of full renewal in yearly cycle.Antler regeneration along with the rapid generation of skin,blood vessels and nerves,and a variety of peptides and growth factors are involved,all of that are regulated by a series of complex and sophisticated signal pathways.This paper summarizes the histological progress of antler regeneration and the present research status of signaling pathways thereof,with a focus on signal transduction pathways to reveal the mystery of antler regeneration,with the aim to gain a better understanding of the mechanism of mammalian organ regeneration.
Deer antlers,derivatives of periosteum cells,are the only mammalian appendages capable of full renewal in yearly cycle.Antler regeneration along with the rapid generation of skin,blood vessels and nerves,and a variety of peptides and growth factors are involved,all of that are regulated by a series of complex and sophisticated signal pathways.This paper summarizes the histological progress of antler regeneration and the present research status of signaling pathways thereof,with a focus on signal transduction pathways to reveal the mystery of antler regeneration,with the aim to gain a better understanding of the mechanism of mammalian organ regeneration.
引文
[1]江润祥,高锦明,叶大同,等.鹿茸表皮生长因子[J].动物学报,1987,33(4):301-308.
[2]李光玉.梅花鹿、马鹿营养、血液IGF1浓度及鹿茸生长规律研究[D].北京:中国农业科学院.2005.
[3]聂毅磊.鹿茸中神经生长因子的分离,纯化和表征[M].福州:福州大学,2002.
[4]王大涛,赵海平,褚文辉,等.梅花鹿S100A4基因的克隆及融合蛋白的表达[J].兽类学报,2011,31(1):103-107.
[5]王秋玉,王本祥.论鹿茸生长因子[J].中医药学报,2000(6):10-11.
[6]徐代勋,梅花鹿鹿茸角柄骨膜不同部位差异蛋白的筛选[D].江苏,江苏科技大学:2011.
[7]Adams JL.1979.Innervation and blood supply of the antler pedicle of the red deer.N Z Vet J 27:200-201.
[8]Ambartsumian N,Grigorian M,Lukanidin E.Genetically modified mouse models to study the role of metastasis-promoting S100 A4(mtsl)protein in metastatic mammary cancer.J Dairy Res 2005;72 Spec No:27-33.
[9]Chunyi Li,Liu Z,Zhao S.Variation of testosterone and estradiol levels in plasma during each developmental stage of sika deer antler[J].Acta Theriol Sin 1988;8(3):224-231.
[10]Chunyi Li;Sheard PW,Corson ID,et al.Pedicle and antler development following sectioning of the sensory nerves to the antlerogenie region of red deer(Cervus elaphus).J Exp Zool 1993(267):188-197.
[11]Chunyi Li,James M.Suttie.Deer antlerogenie periosteum;a piece of postnatally retained embryonic tissue[J].Anat Embryol(2001),204:375-388.
[12]Chunyi Li,Littlejohn RP,Corson ID,et al.Effects of testosterone on pedicle formation and its transformation to antler in castrated male,freemartin and normal female red deer(Cervus elaphus).Gen Comp Endocrinology 2003;131(1):21-31.
[13]Chunyi Li,Fuhe Yang and Allan Sheppard.Adult Stem Cells and Mammalian Epimorphic Regeneration-Insights from Studying Annual Renewal of Deer antler[J].Current Stem Cell Research&Therapy,2009,4:237-251.
[14]Chunyi Li.Exploration of the mechanism underlying neogensis and regeneration of postnatal mammalian skin;deer antler velvet[J].Nova science publishers Inc 2010(16).
[15]Chunyi Li,Anne Harper,Jonathan Puddick et al.Proteomes and Signalling Pathways of Antler Stem Cells[J].PLosone,2012.
[16]Dawn E.Clark,Chunyi Li,et al.Vascular Localization and Proliferation in the Growing Tip of the Deer Antler[J].The Anatomical Record Part A,2006:973-981.
[17]Donato R.S100:a multigenic family of calcium modulated proteins of the EF-hand type with intracellular and extracellular functional roles[J].Int J Biochem Cell Biol 2001,(33):637-668.
[18]Filipenko NR,MacLeod TJ,YoonC-S,Waisman DM.AnnexinA2 Is a Novel RNA-binding Protein[J].J Biol Chem,2004,279:8723-8731.
[19]G.A.Lincoln.Biology of antlers[M].Londen:JZoolLond,1992,226:517-528.
[20]Goss,Richard J.Section III basic sciences and pathology 24 Problems of Antlerogenesis[M].New York;Clin Orthopaed,1970,69:227-238.
[21]Hitch cock-D egregori SE.Chemotaxis Cofilin in the driver's seat[J].Curr Biol,2006,16(24):1030-1032.
[22]James M S,Robert G,et al,Photoperiod associated changes in insulin like growth factor-1 in Reindeer[J].Endocrinology Printed in USA,1991,129(2):679-682.
[23]J G Mount,M Muzylak,S Allen,et al.Evidence that the canonical wnt signaling pathway regulates deer antler regeneration[J].Developmental Gynamics 2006,235:1390-1399.
[24]K.M.KO,T.T Yip,S.W Tsao,et al.Epidermal growth factor from deer(Cervus elaphus)submaxillary gland and velvet antler[J].Gen Comp Endocrinol,1986,63(3):431-440.
[25]Kierdorf U,Kierdorf H,Thomas Szuwart.Deer antler regeneration;cells,concepts,and controversies[J].J Morphol,2007,268(8):726-738.
[26]Li C,Gao X,Yang F,et al.Development of a nude mouse model for the study of antlerogenesis mechanism of tissue interaction and ossification pathway[J].J Exp Zoolog B Mol Dev Evol,2009,312(2):118-135.
[27]L Weng,Zhou QL,Wang B X,et al.A new polypeptide promoting epidermal cells and chondrocytes proliferation from Cervus elaphus Linnaeus[J].Chinese pharmaceutical 2001,36(12):913-917.
[28]Michael Rendl,Lisa Polak,and Elaine Fuchs.BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties[J].Genes&Development,2008,22;543-557.
[29]M Sadighi.Effect of insulin-like growth factor(IGF-1)and IGF-1 on the growth of antler cells in vitro[J].J Endocrinal,1994,143(3):461-469.
[30]Price J.Allen S.Exploring the mechanisms regulating regeneration of deer antlers[J].Philosophical Trans R Soc Lond B Biology Science,2004,259(1445):809-815.
[31]Rotllant J,Liu D,Yan YL,Postlethwait JH,Westerfield M,Du SJ.Sparc(osteonectin)functions in morphogenesis of the pharyngeal skeleton and inner ear[J].Matrix Biol,2008,27:561-572.
[32]Rosenkilde MM,Schwartz TW.The chemokine system-a major regulator of angiogenesis in health and disease[J].Apmis,2004,112:481-495.
[33]Suttie JM,Fennessy PF,Crosbie SF,et al.Temporal changes in LH and testosterone and their relationship with the first antler in red deer(Cervus elaphus)stags from 3 to 15 months of age[J].J Endocrinol,1991,131(3):467-474.
[34]Weng L,Zhou Q L,Wang B X,et al.A Novel Polypeptide from Cervus elaphus Linnaeus[J].Chin Chemical Letters,2002,13(2):147-150.
[35]Zhiguang Gao and Chunyi Li.The study on the relationship between antler's growth rate,relative bone mass and circulation testosterone,estradiol,AKP in sika deer[J].Acta Veterinaria et ZootechnicaSinica,1988,19(30):224-231.
[36]Zhang Z Q,Zhang Y,WANG BX,et al.Purification and partial characterization of anti-inflammatory peptide from pilose antler of Cervus Nippon Temminck[J].Yao Xue Xue Bao,1992,27(5):321-324.
[2]李光玉.梅花鹿、马鹿营养、血液IGF1浓度及鹿茸生长规律研究[D].北京:中国农业科学院.2005.
[3]聂毅磊.鹿茸中神经生长因子的分离,纯化和表征[M].福州:福州大学,2002.
[4]王大涛,赵海平,褚文辉,等.梅花鹿S100A4基因的克隆及融合蛋白的表达[J].兽类学报,2011,31(1):103-107.
[5]王秋玉,王本祥.论鹿茸生长因子[J].中医药学报,2000(6):10-11.
[6]徐代勋,梅花鹿鹿茸角柄骨膜不同部位差异蛋白的筛选[D].江苏,江苏科技大学:2011.
[7]Adams JL.1979.Innervation and blood supply of the antler pedicle of the red deer.N Z Vet J 27:200-201.
[8]Ambartsumian N,Grigorian M,Lukanidin E.Genetically modified mouse models to study the role of metastasis-promoting S100 A4(mtsl)protein in metastatic mammary cancer.J Dairy Res 2005;72 Spec No:27-33.
[9]Chunyi Li,Liu Z,Zhao S.Variation of testosterone and estradiol levels in plasma during each developmental stage of sika deer antler[J].Acta Theriol Sin 1988;8(3):224-231.
[10]Chunyi Li;Sheard PW,Corson ID,et al.Pedicle and antler development following sectioning of the sensory nerves to the antlerogenie region of red deer(Cervus elaphus).J Exp Zool 1993(267):188-197.
[11]Chunyi Li,James M.Suttie.Deer antlerogenie periosteum;a piece of postnatally retained embryonic tissue[J].Anat Embryol(2001),204:375-388.
[12]Chunyi Li,Littlejohn RP,Corson ID,et al.Effects of testosterone on pedicle formation and its transformation to antler in castrated male,freemartin and normal female red deer(Cervus elaphus).Gen Comp Endocrinology 2003;131(1):21-31.
[13]Chunyi Li,Fuhe Yang and Allan Sheppard.Adult Stem Cells and Mammalian Epimorphic Regeneration-Insights from Studying Annual Renewal of Deer antler[J].Current Stem Cell Research&Therapy,2009,4:237-251.
[14]Chunyi Li.Exploration of the mechanism underlying neogensis and regeneration of postnatal mammalian skin;deer antler velvet[J].Nova science publishers Inc 2010(16).
[15]Chunyi Li,Anne Harper,Jonathan Puddick et al.Proteomes and Signalling Pathways of Antler Stem Cells[J].PLosone,2012.
[16]Dawn E.Clark,Chunyi Li,et al.Vascular Localization and Proliferation in the Growing Tip of the Deer Antler[J].The Anatomical Record Part A,2006:973-981.
[17]Donato R.S100:a multigenic family of calcium modulated proteins of the EF-hand type with intracellular and extracellular functional roles[J].Int J Biochem Cell Biol 2001,(33):637-668.
[18]Filipenko NR,MacLeod TJ,YoonC-S,Waisman DM.AnnexinA2 Is a Novel RNA-binding Protein[J].J Biol Chem,2004,279:8723-8731.
[19]G.A.Lincoln.Biology of antlers[M].Londen:JZoolLond,1992,226:517-528.
[20]Goss,Richard J.Section III basic sciences and pathology 24 Problems of Antlerogenesis[M].New York;Clin Orthopaed,1970,69:227-238.
[21]Hitch cock-D egregori SE.Chemotaxis Cofilin in the driver's seat[J].Curr Biol,2006,16(24):1030-1032.
[22]James M S,Robert G,et al,Photoperiod associated changes in insulin like growth factor-1 in Reindeer[J].Endocrinology Printed in USA,1991,129(2):679-682.
[23]J G Mount,M Muzylak,S Allen,et al.Evidence that the canonical wnt signaling pathway regulates deer antler regeneration[J].Developmental Gynamics 2006,235:1390-1399.
[24]K.M.KO,T.T Yip,S.W Tsao,et al.Epidermal growth factor from deer(Cervus elaphus)submaxillary gland and velvet antler[J].Gen Comp Endocrinol,1986,63(3):431-440.
[25]Kierdorf U,Kierdorf H,Thomas Szuwart.Deer antler regeneration;cells,concepts,and controversies[J].J Morphol,2007,268(8):726-738.
[26]Li C,Gao X,Yang F,et al.Development of a nude mouse model for the study of antlerogenesis mechanism of tissue interaction and ossification pathway[J].J Exp Zoolog B Mol Dev Evol,2009,312(2):118-135.
[27]L Weng,Zhou QL,Wang B X,et al.A new polypeptide promoting epidermal cells and chondrocytes proliferation from Cervus elaphus Linnaeus[J].Chinese pharmaceutical 2001,36(12):913-917.
[28]Michael Rendl,Lisa Polak,and Elaine Fuchs.BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties[J].Genes&Development,2008,22;543-557.
[29]M Sadighi.Effect of insulin-like growth factor(IGF-1)and IGF-1 on the growth of antler cells in vitro[J].J Endocrinal,1994,143(3):461-469.
[30]Price J.Allen S.Exploring the mechanisms regulating regeneration of deer antlers[J].Philosophical Trans R Soc Lond B Biology Science,2004,259(1445):809-815.
[31]Rotllant J,Liu D,Yan YL,Postlethwait JH,Westerfield M,Du SJ.Sparc(osteonectin)functions in morphogenesis of the pharyngeal skeleton and inner ear[J].Matrix Biol,2008,27:561-572.
[32]Rosenkilde MM,Schwartz TW.The chemokine system-a major regulator of angiogenesis in health and disease[J].Apmis,2004,112:481-495.
[33]Suttie JM,Fennessy PF,Crosbie SF,et al.Temporal changes in LH and testosterone and their relationship with the first antler in red deer(Cervus elaphus)stags from 3 to 15 months of age[J].J Endocrinol,1991,131(3):467-474.
[34]Weng L,Zhou Q L,Wang B X,et al.A Novel Polypeptide from Cervus elaphus Linnaeus[J].Chin Chemical Letters,2002,13(2):147-150.
[35]Zhiguang Gao and Chunyi Li.The study on the relationship between antler's growth rate,relative bone mass and circulation testosterone,estradiol,AKP in sika deer[J].Acta Veterinaria et ZootechnicaSinica,1988,19(30):224-231.
[36]Zhang Z Q,Zhang Y,WANG BX,et al.Purification and partial characterization of anti-inflammatory peptide from pilose antler of Cervus Nippon Temminck[J].Yao Xue Xue Bao,1992,27(5):321-324.