摘要
皮肤损伤,作为一类极具危险性和高支出的临床问题,亟须行之有效的治疗方案,对于各类创伤敷料的研制成为当今的一大研究热点[1]。静电纺丝纳米纤维膜由于其空间结构很好的模拟了细胞外基质,并且具有孔隙率高,比表面积大,透气、透水性良好,易于制备等特点,使其在制备创伤敷料方面具有显著优势[2]。壳聚糖,一种来源甲壳类动物外骨骼中的多糖,具有抗菌,抗感染等作用,被广泛用于制备各类创伤敷料[3]。但高分子量壳聚糖在常见有机溶剂中的溶解度差,限制了其应用[4]。本文用开环聚合法制备了氨基保留的D,L-聚乳酸接枝壳聚糖,改善了其溶解性,并将其与聚碳酸亚丙酯共混,采用高压静电纺丝方法制备了装载姜黄素的D,L-聚乳酸接枝壳聚糖/聚碳酸亚丙酯(PPC)共混纳米纤维。通过大鼠动物实验证实了其对皮肤损伤修复具有明显的促进作用。
Wounds, urgent healthcare problems and high cost clinical issues, are calling for efficient dressings to accelerate healing process [1]. Electrospinning is a feasible method to obtain nanofibers of which the three-dimensional structures mimics the extracellular matrix(ECM). Additionally, large porosity, nonwoven structure and proper gas permeability enable electrospinning mats to be used as wound dressings [2]. Chitosan, a polysaccharide derived from exoskeleton of crustacean, has been widely used for preparing functional wound dressings depending on its antibacteria and anti-infection properties [3]. However, poor solubility of chitosan in common organic solvents of chitosan confine its applications [4]. In this study, we grafted poly(_(D,L)-lactide) onto chitosan backbone(PDLLA-g-CS), on which poly(_(D,L)-lactide) improved its solubility, and fabricated curcumin loaded PDLLA-g-CS/Poly propylene carbonate(PPC) electrospinning nanofibers. Their enhanced wound healing efficacy has been certified.
引文
[1]Parani M.;Lokhande G.;Singh A.;et al.ACS Appl.Mater.Interfaces.2016,8:10049-10069.
[2]Mei L.;Wang Y.L.;Tong A.P.;et al.Expert Opin.Drug Deliv.2016,13(5):741-53.
[3]Mogos G.D.;Grumezescu A.M.Inte.J.Pharm.2014,463:127-136.
[4]Duan K.R.;Chen H.L.;Huang J.;et al.Carbohydr.Polym.2010,80:498-503.