High expression of BCAP31 correlated with lung cancer severity
详细信息 查看官网全文
- 英文论文题名：High expression of BCAP31 correlated with lung cancer severity
- 论文作者：Wang Jing ; Sun Yuanjie ; Yang Shuya ; Li Ruichao ; Zhang Zhipei ; Yang Kun
- 英文论文作者：Wang Jing ; Sun Yuanjie ; Yang Shuya ; Li Ruichao ; Zhang Zhipei ; Yang Kun ; The Fourth Military Medical University
- 年：2016
- 作者机构：The Fourth Military Medical University;
- 英文论文关键词：Lung cancer ; malignancy ; BCAP31 ; cellular behavior
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R734.2
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：1012k
- 原文格式：D
- 会议级别：全国
摘要
Objective: Lung cancer contributes to the major fatality caused by neoplasm worldwide, leading to one of the most severe health problems which modern people faced with. However, traditional treatments such as surgery operation or chemotherapies are not satisfactory since prognosis is always compromised by tumor recurrence or distant metastasis to vital organs. Immunotherapies nowadays shed new light on malignance management, yet more specific target need to be discovered for pulmonary malignancy. Our previous study defined BCAP31 as a novel cancer/testis(CT) antigen, which regulated cervix cancer development. Our observations also presented hints that the increased expression of BCAP31 should have effects on other carcinomas, lung cancer included. So, whether there is an association between BCAP31 and lung cancer need to be proved. Methods: In our research, we used q-PCR, western blot, immunohistochemistry, HE and several other methods to find the correlation between BCAP31 and lung cancer. Results: In the current research, we confirmed that the ectopic expression pattern was positive correlated to the severity of pulmonary malignancy, by immunohistochemistry results of more than 400 clinical biopsies with tumor and normal control. Further cellular analysis was performed after BCAP31 siRNA knock-down and cell line A549 behaved obvious compromised capabilities in growth, proliferation, migration, et al. Conclusion: BCAP31 was indicated as a novel target by paralleled correlation between BCAP31 expression and clinic conditions with its cancer cellular regulating functions. Yet, the mechanism of BCAP31 in cancer development remains unclear, thus, further researches are warranted.
Objective: Lung cancer contributes to the major fatality caused by neoplasm worldwide, leading to one of the most severe health problems which modern people faced with. However, traditional treatments such as surgery operation or chemotherapies are not satisfactory since prognosis is always compromised by tumor recurrence or distant metastasis to vital organs. Immunotherapies nowadays shed new light on malignance management, yet more specific target need to be discovered for pulmonary malignancy. Our previous study defined BCAP31 as a novel cancer/testis(CT) antigen, which regulated cervix cancer development. Our observations also presented hints that the increased expression of BCAP31 should have effects on other carcinomas, lung cancer included. So, whether there is an association between BCAP31 and lung cancer need to be proved. Methods: In our research, we used q-PCR, western blot, immunohistochemistry, HE and several other methods to find the correlation between BCAP31 and lung cancer. Results: In the current research, we confirmed that the ectopic expression pattern was positive correlated to the severity of pulmonary malignancy, by immunohistochemistry results of more than 400 clinical biopsies with tumor and normal control. Further cellular analysis was performed after BCAP31 siRNA knock-down and cell line A549 behaved obvious compromised capabilities in growth, proliferation, migration, et al. Conclusion: BCAP31 was indicated as a novel target by paralleled correlation between BCAP31 expression and clinic conditions with its cancer cellular regulating functions. Yet, the mechanism of BCAP31 in cancer development remains unclear, thus, further researches are warranted.
Objective: Lung cancer contributes to the major fatality caused by neoplasm worldwide, leading to one of the most severe health problems which modern people faced with. However, traditional treatments such as surgery operation or chemotherapies are not satisfactory since prognosis is always compromised by tumor recurrence or distant metastasis to vital organs. Immunotherapies nowadays shed new light on malignance management, yet more specific target need to be discovered for pulmonary malignancy. Our previous study defined BCAP31 as a novel cancer/testis(CT) antigen, which regulated cervix cancer development. Our observations also presented hints that the increased expression of BCAP31 should have effects on other carcinomas, lung cancer included. So, whether there is an association between BCAP31 and lung cancer need to be proved. Methods: In our research, we used q-PCR, western blot, immunohistochemistry, HE and several other methods to find the correlation between BCAP31 and lung cancer. Results: In the current research, we confirmed that the ectopic expression pattern was positive correlated to the severity of pulmonary malignancy, by immunohistochemistry results of more than 400 clinical biopsies with tumor and normal control. Further cellular analysis was performed after BCAP31 siRNA knock-down and cell line A549 behaved obvious compromised capabilities in growth, proliferation, migration, et al. Conclusion: BCAP31 was indicated as a novel target by paralleled correlation between BCAP31 expression and clinic conditions with its cancer cellular regulating functions. Yet, the mechanism of BCAP31 in cancer development remains unclear, thus, further researches are warranted.
引文