血清脂蛋白相关磷脂酶A2和超敏C-反应蛋白水平与大动脉粥样硬化性脑梗死关系的临床研究
详细信息 查看官网全文
- 论文作者：许岩 ; 诸兴明 ; 陈阳 ; 万琦 ; 赵继来
- 年：2016
- 作者机构：中国人民解放军第101医院神经内科;江苏省无锡市第三人民医院;
- 论文关键词：磷脂酶A2 ; 超敏C-反应蛋白 ; 脑梗死
- 英文论文关键词：Phospholipase A2 ; Allergic C-reactive protein ; Cerebral infarction
- 会议召开时间：2016年6月
- 会议录名称：2016《中国组织化学与细胞化学》杂志临床研究研讨会论文汇编
- 语种：中文
- 分类号：R743.3
- 学会代码：ZHXB
- 会议名称：2016《中国组织化学与细胞化学》杂志临床研究研讨会
- 会议地点：中国北京
- 主办单位：《中国组织化学与细胞化学杂志》社有限公司
- 学会名称：《中国组织化学与细胞化学杂志》社有限公司
- 页数：1
- 文件大小：125k
- 原文格式：O
- 会议级别：全国
摘要
目的:研究血清脂蛋白相关磷脂酶A2(Lp-PLA2)和超敏C-反应蛋白(hs-CRP)水平与大动脉粥样硬化性脑梗死的关系。方法:回顾分析2013年04月到2016年04月期间在我院治疗的40例大动脉粥样硬化性脑梗死患者临床资料,并选取同期在我院体检的40例健康者为对照,对比两组血清脂蛋白相关磷脂酶A2和超敏C-反应蛋白水平。结果:脑梗死组患者Lp-PLA2、hs-CRP、甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、纤维蛋白原(FIB)、尿酸(UA)水平高于对照组,差异有统计学意义(P<0.05);Lp-PLA2与HDL-C呈负相关,与TC、LDL-C、脂蛋白(a)呈正相关(P<0.05)。结论:Lp-PLA2、hs-CRP参与大动脉粥样硬化性脑梗死的病理过程,可能与大动脉粥样硬化性脑梗死颈动脉狭窄程度有关,可以作为临床对大动脉粥样硬化性脑梗死颈动脉狭窄程度的预测指标。
Objective:To study the serum lipoprotein associated phospholipase A2(Lp- PLA2) and allergic C- reactive protein(hs- CRP) level and the relationship between the artery atherosclerotic cerebral infarction.Methods:retrospective analysis of April 04,2013 to 2013 in our hospital during the period of treatment of 40 cases of aortic atherosclerotic cerebral infarction patients with clinical data,and USES the same period in our hospital check- up of 40 cases of healthy subjects as controls,compared two groups of serum lipoprotein associated phospholipase A2 and allergic C- reactive protein level.Results:the patients with cerebral infarction group Lp PLA2,hs CRP,triglycerides(TG),cholesterol(TC),high- density lipoprotein(HDL- C),low density lipoprotein(LDL)- c),fibrinogen(FIB),uric acid(UA) levels higher than the control group,the difference was statistically significant(P < 0.05):Lp- PLA2 and negatively correlated with HDL- C,and TC,LDL- C,lipoprotein(a) were positively correlated(P < 0.05).Conclusion:Lp PLA2,hs CRP in artery atherosclerosis sex of the pathological process of cerebral infarction,may be related to the artery atherosclerotic cerebral infarction carotid stenosis degree,can be used as a clinical of artery atherosclerotic cerebral infarction carotid stenosis degree of predictors.
Objective:To study the serum lipoprotein associated phospholipase A2(Lp- PLA2) and allergic C- reactive protein(hs- CRP) level and the relationship between the artery atherosclerotic cerebral infarction.Methods:retrospective analysis of April 04,2013 to 2013 in our hospital during the period of treatment of 40 cases of aortic atherosclerotic cerebral infarction patients with clinical data,and USES the same period in our hospital check- up of 40 cases of healthy subjects as controls,compared two groups of serum lipoprotein associated phospholipase A2 and allergic C- reactive protein level.Results:the patients with cerebral infarction group Lp PLA2,hs CRP,triglycerides(TG),cholesterol(TC),high- density lipoprotein(HDL- C),low density lipoprotein(LDL)- c),fibrinogen(FIB),uric acid(UA) levels higher than the control group,the difference was statistically significant(P < 0.05):Lp- PLA2 and negatively correlated with HDL- C,and TC,LDL- C,lipoprotein(a) were positively correlated(P < 0.05).Conclusion:Lp PLA2,hs CRP in artery atherosclerosis sex of the pathological process of cerebral infarction,may be related to the artery atherosclerotic cerebral infarction carotid stenosis degree,can be used as a clinical of artery atherosclerotic cerebral infarction carotid stenosis degree of predictors.
引文
[1]中华医学会神经病分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[2]卓明峰,徐尚华,张忠源.颈动脉粥样硬化与脂蛋白相关磷脂酶A2的相关性.中国动脉硬化杂志,2009,17:774-776.
[3]Brilakis ES,Khera A,Mcguire DK,et al.Influence of race and sex on lipoprotein-associated phospholipese A2 levels observations from theDallas Heart Study.Arteriosclerosis,2011,199:110-115.
[4]李青芳,等.脂蛋白相关磷脂酶A2与脑梗死患者颈动脉不稳定粥样斑块的关系.实用医学杂志,2009,25:224-226.
[2]卓明峰,徐尚华,张忠源.颈动脉粥样硬化与脂蛋白相关磷脂酶A2的相关性.中国动脉硬化杂志,2009,17:774-776.
[3]Brilakis ES,Khera A,Mcguire DK,et al.Influence of race and sex on lipoprotein-associated phospholipese A2 levels observations from theDallas Heart Study.Arteriosclerosis,2011,199:110-115.
[4]李青芳,等.脂蛋白相关磷脂酶A2与脑梗死患者颈动脉不稳定粥样斑块的关系.实用医学杂志,2009,25:224-226.