4-羟基苯甲醛-2-氨基噻唑-4-甲酰腙的合成和表征
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- 英文论文题名：The synthesis,characterization of 4-hydroxybenzaldehyde-2-aminothiazole-4-carbonylhydrazone
- 论文作者：刘萌 ; 刘向荣 ; 孙秀超 ; 杨征 ; 赵顺省
- 英文论文作者：Meng Liu ; Xiangrong Liu ; Xiuchao Sun ; Zheng Yang ; Shunsheng Zhao ; College of Chemistry and Chemical Engineering ; Xi'an University of Science and Technology
- 年：2016
- 作者机构：西安科技大学化学与化工学院;
- 论文关键词：酰腙化合物 ; 晶体结构 ; 热稳定性 ; CT-DNA
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十八分会：化学生物学
- 语种：中文
- 分类号：O626.25
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十八分会 ; 化学生物学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：360k
- 原文格式：D
- 会议级别：全国
摘要
以2-氨基噻唑-4-甲酸乙酯、水合肼和4-羟基苯甲醛为原料,合成了新型酰腙化合物4-羟基苯甲醛-2-氨基噻唑-4-甲酰腙(C_(11)H_(10)N_4O_2S)。采用元素分析和X-射线单晶衍射对化合物进行结构表征,可知化合物属于正交晶系,空间群为Pbcn,晶胞参数为:a=12.143nm,b=14.118 nm,c=15.257nm,β=90.000°。利用热重实验探究了化合物的热稳定性,采用Kissinger和Ozawa公式计算了其热分解过程的表观活化能Ea分别为169.30 kJ·mol~(-1)和169.70 kJ·mol~(-1),说明该化合物热稳定性较高。通过紫外吸收光谱测试发现化合物与CT-DNA是以插入方式相互作用。
The new acylhydrazone compound of 4-hydroxybenzaldehyde-2-aminothiazole-4-carbonylhydrazone(C_(11)H_(10)N_4O_2S) was synthesized from 2-aminothiazole-4-methylformate,hydrazine hydrate and hydroxyl benzaldehyde.Its structure was determined by element analysis and X-ray single crystal diffraction.The X-ray single crystal diffraction showed that the crystal of the compound belonged to Orthorhombic,space group Pbcn with a=12.143 nm,b=14.118 nm,c=15.257 nm,β=90.000°.Thermal gravity analysis was used to investigate the thermal stability of the compound,the apparent activation energy Ea of the thermal decomposition for the compound was calculated by Kissinger(Ea= 169.30 kJ·mol~(-1)) and Ozawa(Ea=169.70 kJ·mol~(-1)) methods respectively,showing the compound has good thermal stability.The binding mode of compound with CT-DNA was studied by UV-Vis absorption,showing that the interaction of compound with CT-DNA belonged to partial intercalation mode.
The new acylhydrazone compound of 4-hydroxybenzaldehyde-2-aminothiazole-4-carbonylhydrazone(C_(11)H_(10)N_4O_2S) was synthesized from 2-aminothiazole-4-methylformate,hydrazine hydrate and hydroxyl benzaldehyde.Its structure was determined by element analysis and X-ray single crystal diffraction.The X-ray single crystal diffraction showed that the crystal of the compound belonged to Orthorhombic,space group Pbcn with a=12.143 nm,b=14.118 nm,c=15.257 nm,β=90.000°.Thermal gravity analysis was used to investigate the thermal stability of the compound,the apparent activation energy Ea of the thermal decomposition for the compound was calculated by Kissinger(Ea= 169.30 kJ·mol~(-1)) and Ozawa(Ea=169.70 kJ·mol~(-1)) methods respectively,showing the compound has good thermal stability.The binding mode of compound with CT-DNA was studied by UV-Vis absorption,showing that the interaction of compound with CT-DNA belonged to partial intercalation mode.
引文
[1]陈延民,王景梅,陈飞鹏,陈雅心,曾倩茹,谢庆范.无机化学学报,2016,32(3):434.
[2]刘向荣,孙秀超,杨再文,杨水兰,赵顺省,闫森.无机化学学报,2016,32(2):250.
[2]刘向荣,孙秀超,杨再文,杨水兰,赵顺省,闫森.无机化学学报,2016,32(2):250.