怀菊花中的黄酮类化学成分
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- 英文论文题名：Flavonoids from the flowers of Chrysanthemum morifolium Ramat
- 论文作者：陈文静 ; 郑晓珂 ; 曹彦刚 ; 弓建红 ; 李方 ; 赵璇 ; 郭月婷 ; 齐曼 ; 郭孟焕 ; 冯卫生
- 英文论文作者：Chen Wen-jing ; Zheng Xiao-ke ; Cao Yan-gang ; Gong Jian-hong ; Li-Fang ; Zhao xuan ; Guo Yue-ting ; Qi man ; Guo meng-huan ; Feng Wei-sheng ; College of Pharmacy ; Henan University of Traditional Chinese Medicine ; Collaborative Innovation Center for Respiratory Disease And Treatment & Chinese Medicine Development of Henan Province ; College of Pharmacy ; Heilongjiang University of Traditional Chinese Medicine
- 年：2016
- 作者机构：河南中医药大学药学院;呼吸疾病诊疗与新药研发河南省协同创新中心;黑龙江中医药大学药学院;
- 论文关键词：怀菊花 ; 化学成分 ; 黄酮
- 英文论文关键词：Chrysanthemum morifolium Ramat ; Chemical constituents ; flavonoids
- 会议召开时间：2016-09-27
- 会议录名称：中国药学会第十三届青年药学科研成果交流会论文集
- 语种：中文
- 分类号：R284
- 学会代码：YYWS
- 会议名称：中国药学会第十三届青年药学科研成果交流会
- 会议地点：中国江西南昌
- 主办单位：中国药学会
- 学会名称：中国药学会
- 页数：3
- 文件大小：238k
- 原文格式：O
- 会议级别：全国
摘要
目的:对怀菊花的化学成分进行分离和结构鉴定。方法:利用Diaion HP-20,硅胶柱等柱色谱技术以及制备液相手段进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果:分离并鉴定了9个黄酮类化合物的结构,分别为:木犀草素(1),芹菜素(2),金合欢素(3),香叶木素(4),圣草酚(5),金合欢素-7-0-β-D-葡萄糖苷(6),5-羟基-3′,4′,6,7-四甲氧基黄酮(7),柚皮素(8),洋艾素(9)。结论:化合物1-9均为首次从该植物中分离得到。
Objective To study the chemical constituents in the flowers of Chrysanthemum morifolium Ramat.Methods The compounds were isolated with Diaion HP-20,Sephadex LH-20,Silica gel column chromatography and preparative HPLC.Structures of compounds were identified by physiochemical properties and spectral analysis.Results Nine compounds were obtained,and their structures were identified as,luteolin(l),apigenin(2),acacetin(3),diosmetin(4),eriodictyol(5),acacetin-7-0-P-D-glucopyranoside(6),5-hydroxy-3',4',6,7-tetramethoxyflavone(7),naringenin(8),artemitin(9).Conclution compounds 1-9 are isolated for the first time from this plant.
Objective To study the chemical constituents in the flowers of Chrysanthemum morifolium Ramat.Methods The compounds were isolated with Diaion HP-20,Sephadex LH-20,Silica gel column chromatography and preparative HPLC.Structures of compounds were identified by physiochemical properties and spectral analysis.Results Nine compounds were obtained,and their structures were identified as,luteolin(l),apigenin(2),acacetin(3),diosmetin(4),eriodictyol(5),acacetin-7-0-P-D-glucopyranoside(6),5-hydroxy-3',4',6,7-tetramethoxyflavone(7),naringenin(8),artemitin(9).Conclution compounds 1-9 are isolated for the first time from this plant.
引文
[1]Chinese Pharmacopoeia Commission.The Drug Standard of Ministry of Health of P.R[M].China Medical Science and Technology Publishin,2015,310.
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[4]XIE Y Y.Studies on biozctive constituents of three natural medicines-pericarps of sapindus rarak,flowers of Chrysanthemum morifolium ramat.'huaijuhua'.CV.NOV,and punica granatun[D].Shenyang:Shenyang pharmaceutical University Pharmacognosy 2009.
[5]ZHANG Y H,LIU Y,HU J,et al.Study on Flavonoids in mint[J].Chinese Traditional and Herbal Drugs,2006,37(4):512-514.
[6]GE Y B.Chemical Constituents of Fortunella margarita Fruits[J].Journal of Chinese Medicinal Materials,2014.37(3):435-438.
[7]F.He,H.A.Aisa,Kh.M.Shakhidoyatov.Flavones from Artemisia rupestris[J].Chemistry of Natural Compounds,2012,48(4):685-686.
[2]Li T,Lian S.Henan Specialty Huai Chrysanthemum[J].Special Wild Economic Animal and Plant Research,1992,3:33.
[3]ZHANG Y L.Chemical constituents from the leaves of rehmannia glutinosa libosch[D].Harbin:College of Pharmacy,Heilongjiang University of Traditional Chinese Medicine 2013.
[4]XIE Y Y.Studies on biozctive constituents of three natural medicines-pericarps of sapindus rarak,flowers of Chrysanthemum morifolium ramat.'huaijuhua'.CV.NOV,and punica granatun[D].Shenyang:Shenyang pharmaceutical University Pharmacognosy 2009.
[5]ZHANG Y H,LIU Y,HU J,et al.Study on Flavonoids in mint[J].Chinese Traditional and Herbal Drugs,2006,37(4):512-514.
[6]GE Y B.Chemical Constituents of Fortunella margarita Fruits[J].Journal of Chinese Medicinal Materials,2014.37(3):435-438.
[7]F.He,H.A.Aisa,Kh.M.Shakhidoyatov.Flavones from Artemisia rupestris[J].Chemistry of Natural Compounds,2012,48(4):685-686.