Integration and Synchronization of Nano-properties of Self-Adapting Cancer Nanomedicine for Active Cancer Drug Delivery
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- 英文论文题名：Integration and Synchronization of Nano-properties of Self-Adapting Cancer Nanomedicine for Active Cancer Drug Delivery
- 论文作者：Youqing Shen ; Xuanrong Sun ; Jianbin Tang ; Meihua Sui ; Xiangrui Liu
- 英文论文作者：Youqing Shen ; Xuanrong Sun ; Jianbin Tang ; Meihua Sui ; Xiangrui Liu ; Center for Bionanoengineering ; Department of Chemical and Biological Engineering ; Zhejiang University
- 年：2016
- 作者机构：Center for Bionanoengineering, Department of Chemical and Biological Engineering, Zhejiang University;
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：英文
- 分类号：TB383.1;TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：82k
- 原文格式：D
- 会议级别：全国
摘要
The cancer drug delivery process is a cascade of five steps consisting of Circulation in blood,Accumulation and Penetration into the tumor, cellular Internalization and intracellular drug Release, or the CAPIR cascade. Thus, only if a nanomedicine efficiently goes through all the steps would it realize high therapeutic efficiency. The ability of a nanomedicine accomplishing the CAPIR steps is mainly determined by its three key nanoproperties, i.e., Size, Surface and Stability(3S nanoproperties), whose optima are different and even opposite in different steps. Thus, the utmost challenge in design of effective cancer nanomedicine is how to integrate and synchronize these incompatible 3S nanoproperties into one system. Here, we present a concept of active nanomedicine self-adapting to the CAPIR cascade steps. One example is a nanomedicine likened to a "cluster bomb" capable of releasing small p H-sensitive drug-carrying nanoparticles(bomblets). This cluster bomb-like nanocarrier synchronizes pegylation-to-depegylation, large-to-small size, and neutral-to-positive charge, stable-to-instable(i.e. 3S nanoproperty) transitions, essential for accomplishing the CAPIR cascade. Another example is the lipidic charge-reversal polyplexes for effective gene delivery.
The cancer drug delivery process is a cascade of five steps consisting of Circulation in blood,Accumulation and Penetration into the tumor, cellular Internalization and intracellular drug Release, or the CAPIR cascade. Thus, only if a nanomedicine efficiently goes through all the steps would it realize high therapeutic efficiency. The ability of a nanomedicine accomplishing the CAPIR steps is mainly determined by its three key nanoproperties, i.e., Size, Surface and Stability(3S nanoproperties), whose optima are different and even opposite in different steps. Thus, the utmost challenge in design of effective cancer nanomedicine is how to integrate and synchronize these incompatible 3S nanoproperties into one system. Here, we present a concept of active nanomedicine self-adapting to the CAPIR cascade steps. One example is a nanomedicine likened to a "cluster bomb" capable of releasing small p H-sensitive drug-carrying nanoparticles(bomblets). This cluster bomb-like nanocarrier synchronizes pegylation-to-depegylation, large-to-small size, and neutral-to-positive charge, stable-to-instable(i.e. 3S nanoproperty) transitions, essential for accomplishing the CAPIR cascade. Another example is the lipidic charge-reversal polyplexes for effective gene delivery.
The cancer drug delivery process is a cascade of five steps consisting of Circulation in blood,Accumulation and Penetration into the tumor, cellular Internalization and intracellular drug Release, or the CAPIR cascade. Thus, only if a nanomedicine efficiently goes through all the steps would it realize high therapeutic efficiency. The ability of a nanomedicine accomplishing the CAPIR steps is mainly determined by its three key nanoproperties, i.e., Size, Surface and Stability(3S nanoproperties), whose optima are different and even opposite in different steps. Thus, the utmost challenge in design of effective cancer nanomedicine is how to integrate and synchronize these incompatible 3S nanoproperties into one system. Here, we present a concept of active nanomedicine self-adapting to the CAPIR cascade steps. One example is a nanomedicine likened to a "cluster bomb" capable of releasing small p H-sensitive drug-carrying nanoparticles(bomblets). This cluster bomb-like nanocarrier synchronizes pegylation-to-depegylation, large-to-small size, and neutral-to-positive charge, stable-to-instable(i.e. 3S nanoproperty) transitions, essential for accomplishing the CAPIR cascade. Another example is the lipidic charge-reversal polyplexes for effective gene delivery.
引文
[1]X.Liu,J.Xiang,D.Zhu,L.Jiang,Z.Zhou,J.Tang,X.Liu,Y.Huang and Y.Shen*.Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery,2016,28,1743–1752.DOI:10.1002/adma.201504288.
[2]Q.Sun,X.Sun,X.Ma,Z.Zhou,E.Jin,B.Zhang,Y.Shen*,E.A.Van Kirk,W.J.Murdoch,J.R.Lott,T.P.Lodge,M.Radosz,Y.Zhao*,Integration of nanoassembly functions for an effective delivery cascade for cancer drugs,Advanced Materials 2014,26,7615-7621.
[3]Z.X.Zhou,X.P.Ma,C.J.Murphy,E.L Jin,Q.H.Sun,Y.Shen*,E.A.Van Kirk,W.J.Murdoch:Molecularly Precise Dendrimer-Drug Conjugates with Tunable Drug Release for Cancer Therapy.Angewandte Chemie-International Edition 2014,53(41):10949-10955.
[2]Q.Sun,X.Sun,X.Ma,Z.Zhou,E.Jin,B.Zhang,Y.Shen*,E.A.Van Kirk,W.J.Murdoch,J.R.Lott,T.P.Lodge,M.Radosz,Y.Zhao*,Integration of nanoassembly functions for an effective delivery cascade for cancer drugs,Advanced Materials 2014,26,7615-7621.
[3]Z.X.Zhou,X.P.Ma,C.J.Murphy,E.L Jin,Q.H.Sun,Y.Shen*,E.A.Van Kirk,W.J.Murdoch:Molecularly Precise Dendrimer-Drug Conjugates with Tunable Drug Release for Cancer Therapy.Angewandte Chemie-International Edition 2014,53(41):10949-10955.