甘氨酸羟胺氧钒配合物的合成、晶体结构和抗糖尿病活性研究
详细信息 查看官网全文
- 英文论文题名：Synthesis,crystal structures and anti-diabetic effects of vanadium compounds with glycine and hydroxylamine
- 论文作者：张恒强 ; 吴琼 ; 马闯 ; 玄兆坤 ; 陈鸿利
- 英文论文作者：Hengqiang Zhang ; Qiong Wu ; Chuang Ma ; Zhaoxun Xuan ; Hongli Chen ; School of Chemistry and Chemical Engineering ; Hebei Normal University for Nationalities
- 年：2016
- 作者机构：河北民族师范学院化学与化工学院;
- 论文关键词：氧钒配合物 ; 合成 ; 晶体结构 ; 抗糖尿病活性
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第十六分会：晶体工程
- 语种：中文
- 分类号：R914.5;R96;O641.4
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第十六分会 ; 晶体工程
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：200k
- 原文格式：D
- 会议级别：全国
摘要
氨基酸氧钒类金属配合物近年来由于具有较强的生物活性而引起人们广泛关注[1-2]。本文在水溶液中,用偏钒酸铵与甘氨酸和盐酸羟胺反应,制备了一种新型配合物晶体[V(Gly)(NH_2O)_2]·H_2O(Gly:甘氨酸)。通过元素分析、X射线单晶衍射、红外光谱、紫外光谱对其结构和谱学性质进行了表征,并通过研究其对PTP1B酶的抑制活性来研究其抗糖尿病活性。测试结果发现该标题配合物在温20μg/mL的浓度下,对PTP1B酶的抑制活性可高达80.31%,表明配合物有良好的抗糖尿病活性。单晶解析结果表明,该配合物属单斜晶系,P2(1)/C群,中心钒原子与7个配位的氮氧原子形成扭曲的五角双锥构型,其晶体结构见图1。
A novel vanadium compounds[V(Gly)(NH_2O)_2]·H_2O has been prepared.Its structure was characterized by elemental analysis,IR,X-ray diffraction single structure analysis and thermal analysis.The complexe crystallize in monoclinic system with space group P2(1)/c,the central vanadium and seven coordinated atoms form adistorted pentagonal bipyramidal.Two O atoms and three N atoms from hydroxylamine and amino-acids define an equatorial plane approximately perpendicular to V=O.The complex displays a good inhibitory activity against PTP1B(inhibition rate is 80.31%at 20 μg /mL).
A novel vanadium compounds[V(Gly)(NH_2O)_2]·H_2O has been prepared.Its structure was characterized by elemental analysis,IR,X-ray diffraction single structure analysis and thermal analysis.The complexe crystallize in monoclinic system with space group P2(1)/c,the central vanadium and seven coordinated atoms form adistorted pentagonal bipyramidal.Two O atoms and three N atoms from hydroxylamine and amino-acids define an equatorial plane approximately perpendicular to V=O.The complex displays a good inhibitory activity against PTP1B(inhibition rate is 80.31%at 20 μg /mL).
引文
[1]Xiucai,Li.;Hengqiang,Zhang;Qiong Yang;Qiying,Zhang.Z.NATURFORSCH.B.2015,70(6),373
[2]张恒强,张其颖,李佳,刘东,吴晓芳,单永奎.高等学校化学学报2012,33,243
[2]张恒强,张其颖,李佳,刘东,吴晓芳,单永奎.高等学校化学学报2012,33,243