摘要
氨基酸氧钒类金属配合物近年来由于具有较强的生物活性而引起人们广泛关注[1-2]。本文在水溶液中,用偏钒酸铵与甘氨酸和盐酸羟胺反应,制备了一种新型配合物晶体[V(Gly)(NH_2O)_2]·H_2O(Gly:甘氨酸)。通过元素分析、X射线单晶衍射、红外光谱、紫外光谱对其结构和谱学性质进行了表征,并通过研究其对PTP1B酶的抑制活性来研究其抗糖尿病活性。测试结果发现该标题配合物在温20μg/mL的浓度下,对PTP1B酶的抑制活性可高达80.31%,表明配合物有良好的抗糖尿病活性。单晶解析结果表明,该配合物属单斜晶系,P2(1)/C群,中心钒原子与7个配位的氮氧原子形成扭曲的五角双锥构型,其晶体结构见图1。
A novel vanadium compounds[V(Gly)(NH_2O)_2]·H_2O has been prepared.Its structure was characterized by elemental analysis,IR,X-ray diffraction single structure analysis and thermal analysis.The complexe crystallize in monoclinic system with space group P2(1)/c,the central vanadium and seven coordinated atoms form adistorted pentagonal bipyramidal.Two O atoms and three N atoms from hydroxylamine and amino-acids define an equatorial plane approximately perpendicular to V=O.The complex displays a good inhibitory activity against PTP1B(inhibition rate is 80.31%at 20 μg /mL).
引文
[1]Xiucai,Li.;Hengqiang,Zhang;Qiong Yang;Qiying,Zhang.Z.NATURFORSCH.B.2015,70(6),373
[2]张恒强,张其颖,李佳,刘东,吴晓芳,单永奎.高等学校化学学报2012,33,243