非情绪与情绪背景下行为抑制在LPFC的功能分化
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- 英文论文题名：The differentiation function of the lateral prefrontal of the behavior control in the context of emotional and non-emotional
- 论文作者：刘颖 ; 白学军 ; 周崧 ; 张琪涵 ; 章鹏
- 英文论文作者：Liu Ying ; Bai Xuejun ; Zhou Song ; Zhang Qihan ; Zhang Peng ; Tianjin Normal University
- 年：2015
- 作者机构：天津师范大学;
- 论文关键词：非情绪背景 ; 情绪背景 ; 行为控制 ; 外侧前额叶 ; 近红外脑功能成像技术
- 英文论文关键词：Non-emotional context ; Emotional context ; Behavior control ; the lateral prefrontal cortex ; functional Near-Infrared Spectroscopy(fNIRS)
- 会议召开时间：2015-10-16
- 会议录名称：第十八届全国心理学学术会议摘要集——心理学与社会发展
- 英文会议录名称：Proceedings of the 18th National Academic Congress of Psychology
- 语种：中文
- 分类号：B842.6
- 学会代码：ZGXG
- 会议名称：第十八届全国心理学学术会议
- 会议地点：中国天津
- 主办单位：中国心理学会
- 学会名称：中国心理学会
- 页数：3
- 文件大小：776k
- 原文格式：D
- 会议级别：全国
摘要
行为抑制是指抑制不符合当前需要的或不恰当的行为反应的能力,它是执行功能的重要部分。早期研究发现,非情绪背景下外侧前额叶调节参与行为抑制的定位不一致。Swick总结前人研究指出,行为抑制时双侧背外侧前额叶,左腹外侧前额叶均有显著激活,而右腹外侧前额叶并没有体现出预期的优势,它在行为抑制中的重要性受到质疑。Herrmann首次采用fN IRS技术,发现反应抑制时腹外侧前额叶双边激活。但Nishimure发现,个体在抑制时背外侧前额叶显著失活,Rodrigo也发现相比于行为反应,右腹外侧前额叶和左外侧前额叶及内侧前额叶显著失活,且失活度与低虚报率相关,提示这些脑区在行为抑制中可能具有更为实质性的作用。人类通常在某种情绪背景下进行活动,情绪体验可能会影响行为控制。过去研究多采用f MRI技术,发现情绪与行为控制加工整合涉及前额叶,但各部分是否参与整合尚不一致。目前还没有采用fN IRS技术直接探查行为控制在情绪背景下涉及的神经生理基础。最近Lena采用该技术测量被试在趋向或回避情绪图片时前额叶的血氧活动,这为我们使用该技术探查情绪背景下行为控制在外侧前额叶的活动提供了可能性启发。因此本研究选用日本岛津公司LABNIRS近红外脑功能成像仪(空间分辨率:2~3cm;时间分辨率:100ms),选择21个探头(11个是发射探头,10个是接收探头),形成一个7×3型矩形通道布局,该布局共含十二个小正方形,其中正方形的每条边为一个通道,共计32个通道。通过两个实验,采用事件相关设计实时记录在校大学生(均为右利手)完成非情绪与情绪go/no go任务时外侧前额叶的血氧活动,。结果发现:在非情绪背景下与情绪背景下,眶额叶皮层、双侧背外侧前额叶可能以神经抑制的活动形式参与行为抑制,而腹外侧前额叶不参与,但它可能并不是行为抑制的重要脑区,但在整合情绪加工与行为控制加工方面很重要,特别是在负性情绪背景时,腹外侧前额叶可能以更大程度的神经抑制的活动方式参与行为控制。
Behavior inhibition refers to the ability to suppress responses that are no longer required or inappropriate, and is also considered to be a key component of processing for executive control. In the past, the fMRI studies of non-emotional go/no-go task generally considered that the right ventrolateral prefrontal plays a critical role in response inhibition, but many subsequent studies have found that the dorsolateral and ventrolateral prefrontal cortex activated bilaterally, medial prefrontal and the supplementary motor area were also be included. Some researchers even emphasized the importance of the pre-SMA. Swick summarized some neuroimaging studies using the go/no go paradigm, and pointed out that bilateral dorsolateral prefrontal cortex and left ventrolateral prefrontal significantly activated under the context of inhibition, and right ventrolateral prefrontal did not reflect the expected advantage, whose important role in behavioral inhibition has been questioned. Herrmann used fNIRS for the first time, and found the ventrolateral prefrontal activated bilaterally. But Nishimure found that the dorsolateral prefrontal cortex of normal people was significant deactivation, and Rodrigo also found that right ventrolateral prefrontal cortex and the left lateral prefrontal cortex and the medial prefrontal were deactivated significantly, and the degree of deactivation was related with the low false alarm rate, prompting these brain areas may play a more substantial role in behavioral inhibition. Human carried out some activities under the background of a certain emotion, and the emotional experience may affect behavior control. Most of these researches used fMRI technology, and found that the integration of emotion processing and behavioral control processing involves the prefrontal cortex, but the result of the differentiation function of the lateral prefrontal cortex was not consistent. There is no fNIRS study exploring the neural mechanism in lateral PFC of response inhibition under the emotional cortex directly. Recently, however, Lena measured the blood oxygen activity in prefrontal when participants were close to or far from the emotional pictures, which inspires us the possibility of exploring the differentiation function of the lateral prefrontal of the behavior control in the context of emotional and non-emotional by using fNIRS. So the current research is going to use the LABNIRS(Japanese,Shimadzu;The spatial resolution:2~3cm; Temporal resolution:100 ms). This study used the event-related design, and recorded the change of oxygenated hemoglobin concentration of the lateral PFC when our college students(right-handed) completed the go/no-go task in real time to explore the neural activity of the lateral PFC under the non-emotional and the emotional contexts. We can draw the conclusions as following:Under the non-emotional context, bilateral DLPFC may participate in behavioral inhibition in the form of neural activity inhibition and VLPFC shall be excluded. The inhibition of neural activity of bilateral DLPFC still be retained in the background of emotion; The OFC may participant in behavioral inhibition task in the way of neural inhibition, associating with other brain regions under the background of emotions and non-emotion; The ventrolateral prefrontal cortex may not be the important area of behavioral inhibition, but the bilateral VLPFC in the integration of emotional and behavioral control is very important. Especially in the background of negative emotions, the VLPFC may be in the form of a greater degree of neural activity inhibition to finish the inhibition task.
Behavior inhibition refers to the ability to suppress responses that are no longer required or inappropriate, and is also considered to be a key component of processing for executive control. In the past, the fMRI studies of non-emotional go/no-go task generally considered that the right ventrolateral prefrontal plays a critical role in response inhibition, but many subsequent studies have found that the dorsolateral and ventrolateral prefrontal cortex activated bilaterally, medial prefrontal and the supplementary motor area were also be included. Some researchers even emphasized the importance of the pre-SMA. Swick summarized some neuroimaging studies using the go/no go paradigm, and pointed out that bilateral dorsolateral prefrontal cortex and left ventrolateral prefrontal significantly activated under the context of inhibition, and right ventrolateral prefrontal did not reflect the expected advantage, whose important role in behavioral inhibition has been questioned. Herrmann used fNIRS for the first time, and found the ventrolateral prefrontal activated bilaterally. But Nishimure found that the dorsolateral prefrontal cortex of normal people was significant deactivation, and Rodrigo also found that right ventrolateral prefrontal cortex and the left lateral prefrontal cortex and the medial prefrontal were deactivated significantly, and the degree of deactivation was related with the low false alarm rate, prompting these brain areas may play a more substantial role in behavioral inhibition. Human carried out some activities under the background of a certain emotion, and the emotional experience may affect behavior control. Most of these researches used fMRI technology, and found that the integration of emotion processing and behavioral control processing involves the prefrontal cortex, but the result of the differentiation function of the lateral prefrontal cortex was not consistent. There is no fNIRS study exploring the neural mechanism in lateral PFC of response inhibition under the emotional cortex directly. Recently, however, Lena measured the blood oxygen activity in prefrontal when participants were close to or far from the emotional pictures, which inspires us the possibility of exploring the differentiation function of the lateral prefrontal of the behavior control in the context of emotional and non-emotional by using fNIRS. So the current research is going to use the LABNIRS(Japanese,Shimadzu;The spatial resolution:2~3cm; Temporal resolution:100 ms). This study used the event-related design, and recorded the change of oxygenated hemoglobin concentration of the lateral PFC when our college students(right-handed) completed the go/no-go task in real time to explore the neural activity of the lateral PFC under the non-emotional and the emotional contexts. We can draw the conclusions as following:Under the non-emotional context, bilateral DLPFC may participate in behavioral inhibition in the form of neural activity inhibition and VLPFC shall be excluded. The inhibition of neural activity of bilateral DLPFC still be retained in the background of emotion; The OFC may participant in behavioral inhibition task in the way of neural inhibition, associating with other brain regions under the background of emotions and non-emotion; The ventrolateral prefrontal cortex may not be the important area of behavioral inhibition, but the bilateral VLPFC in the integration of emotional and behavioral control is very important. Especially in the background of negative emotions, the VLPFC may be in the form of a greater degree of neural activity inhibition to finish the inhibition task.
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