Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's disease Patients with Sleep Disturbances
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- 英文论文题名：Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's disease Patients with Sleep Disturbances
- 论文作者：You Yin ; Liu-Qing Huang ; Zhong-Xin Zhao
- 英文论文作者：You Yin ; Liu-Qing Huang ; Zhong-Xin Zhao ; Department of Neurology ; Changzheng Hospital ; Second Military Medical University
- 年：2016
- 作者机构：Department of Neurology, Changzheng Hospital, Second Military Medical University;
- 英文论文关键词：Alzheimer'sdisease ; Risperidone ; Sleep ; Insomnia ; Circadian ; Hypersomnia ; Sleep/wake patterns ; Antipsychotics ; Caregiver
- 会议召开时间：2016-05-27
- 会议录名称：中国睡眠研究会第九届学术年会汇编
- 语种：英文
- 分类号：R749.16;R740
- 学会代码：OGSF
- 会议名称：中国睡眠研究会第九届学术年会
- 会议地点：中国上海
- 主办单位：中国睡眠研究会
- 学会名称：中国睡眠研究会
- 页数：1
- 文件大小：38k
- 原文格式：O
- 会议级别：全国
摘要
Sleep disturbances(SD) accelerate the progression of Alzheimer's disease(AD) and increase the stress of caregivers.However,the long-term outcome of disturbed nocturnal sleep/wake patterns in AD and on increased stress of spousal caregivers is unclear.This study assessed the 5-year effect of nocturnal SD on the long-term outcome in AD patients.A total of 156 donepezil-treated mildmoderate AD patients(93 AD + SD and 63 AD- SD as a control group) were recruited.The AD + SD patients were formed into 4 subgroups according to the preferences of spousal caregivers for treatment with atypical antipsychotics(0.5-1 mg risperidone,n = 22),non-benzodiazepine hypnotic(5-10 mg Zolpidem tartrate,n = 33),melatonin(2.55 mg,n = 9),or no- drug treatment(n= 29).SD were evaluated by polysomnography,sleep scale,and cognitive scale examinations.Moreover,all spousal caregivers of AD patients were assessed using a series of scales,including sleep,anxiety,mood,and treatment attitude scales.Our data showed that nocturnal sleep/wake disturbances were significantly associated with lower 5-year outcomes for AD patients,earlier nursing home placement,and more negative emotions of spousal caregivers.Treatment with lowdose atypical anti-psychotic risperidone improved the 5-year outcome in AD + SD patients.In conclusion,low-dose atypical antipsychotic risperidone improves the 5-year outcome in AD patients with SD.Moreover,improvement of nocturnal sleep problems in AD patients will also bring better emotional stability for AD caregivers.
Sleep disturbances(SD) accelerate the progression of Alzheimer's disease(AD) and increase the stress of caregivers.However,the long-term outcome of disturbed nocturnal sleep/wake patterns in AD and on increased stress of spousal caregivers is unclear.This study assessed the 5-year effect of nocturnal SD on the long-term outcome in AD patients.A total of 156 donepezil-treated mildmoderate AD patients(93 AD + SD and 63 AD- SD as a control group) were recruited.The AD + SD patients were formed into 4 subgroups according to the preferences of spousal caregivers for treatment with atypical antipsychotics(0.5-1 mg risperidone,n = 22),non-benzodiazepine hypnotic(5-10 mg Zolpidem tartrate,n = 33),melatonin(2.55 mg,n = 9),or no- drug treatment(n= 29).SD were evaluated by polysomnography,sleep scale,and cognitive scale examinations.Moreover,all spousal caregivers of AD patients were assessed using a series of scales,including sleep,anxiety,mood,and treatment attitude scales.Our data showed that nocturnal sleep/wake disturbances were significantly associated with lower 5-year outcomes for AD patients,earlier nursing home placement,and more negative emotions of spousal caregivers.Treatment with lowdose atypical anti-psychotic risperidone improved the 5-year outcome in AD + SD patients.In conclusion,low-dose atypical antipsychotic risperidone improves the 5-year outcome in AD patients with SD.Moreover,improvement of nocturnal sleep problems in AD patients will also bring better emotional stability for AD caregivers.
Sleep disturbances(SD) accelerate the progression of Alzheimer's disease(AD) and increase the stress of caregivers.However,the long-term outcome of disturbed nocturnal sleep/wake patterns in AD and on increased stress of spousal caregivers is unclear.This study assessed the 5-year effect of nocturnal SD on the long-term outcome in AD patients.A total of 156 donepezil-treated mildmoderate AD patients(93 AD + SD and 63 AD- SD as a control group) were recruited.The AD + SD patients were formed into 4 subgroups according to the preferences of spousal caregivers for treatment with atypical antipsychotics(0.5-1 mg risperidone,n = 22),non-benzodiazepine hypnotic(5-10 mg Zolpidem tartrate,n = 33),melatonin(2.55 mg,n = 9),or no- drug treatment(n= 29).SD were evaluated by polysomnography,sleep scale,and cognitive scale examinations.Moreover,all spousal caregivers of AD patients were assessed using a series of scales,including sleep,anxiety,mood,and treatment attitude scales.Our data showed that nocturnal sleep/wake disturbances were significantly associated with lower 5-year outcomes for AD patients,earlier nursing home placement,and more negative emotions of spousal caregivers.Treatment with lowdose atypical anti-psychotic risperidone improved the 5-year outcome in AD + SD patients.In conclusion,low-dose atypical antipsychotic risperidone improves the 5-year outcome in AD patients with SD.Moreover,improvement of nocturnal sleep problems in AD patients will also bring better emotional stability for AD caregivers.
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