Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice
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- 英文论文题名：Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice
- 论文作者：Huang Qingrong ; Jin Min ; Liu Jianhua ; Wang Yanan ; Zhang Yanyun
- 英文论文作者：Huang Qingrong ; Jin Min ; Liu Jianhua ; Wang Yanan ; Zhang Yanyun ; Key Laboratory of Stem Cell Biology ; Institute of Health Sciences ; Shanghai Institutes for Biological Sciences ; Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine ; Shanghai Institute of Immunology ; Institutes of Medical Sciences ; Shanghai Jiao Tong University School of Medicine
- 年：2016
- 作者机构：Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine;Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine;
- 英文论文关键词：GVHD ; Ezh2 ; Hsp90 ; Alloreactive T cells
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会分会场交流报告集
- 英文会议录名称：Proceedings of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R392.4
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：379k
- 原文格式：D
- 会议级别：全国
摘要
<正>Modulating:T cell alloreactivity has been a main strategy to reduce graft-versus-host disease(GVHD),a lifethreatening complication after allogeneic hematopoietic stem cell transplantation(HSCT).Genetic deletion of T cell Ezh2,which catalyzes trimethylation of histone H3 at lysine 27(H3K27me3),inhibits GVHD.Therefore,reducing Ezh2-mediated H3K27me3 is thought to be essential for inhibiting GVHD.Unexpectedly,administration of the
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